Aspergillus Genome Database

该项目的目标是开发一个数据库，基于用于 酵母属和念珠菌属基因组数据库，其中将有 从与特定基因相关的文献中收集的数据。在整理文献时，我们将 还记录基因名称和别名、基因本体注释和突变表型 为探索基因组及其注释提供了工具和界面。此外，我们将 进一步开发和完善一个强大的，最先进的基因组注释管道，并使用它来 对每一个黑曲霉进行初级基因组注释。这条管道将利用 的比较基因组数据之间的aregilli，并将定期重新运行，无论是当 新的数据出现（如额外的基因组），或者当改进的算法被 纳入管道。因此，我们将提供给曲霉研究界高 质量文献为基础的策展，加上最好的可能的主要注释的每一个 基因组通过这种方式，正如其他生物研究社区所做的那样，我们将 帮助加速对古生物学的研究，使研究人员能够轻松地访问相关的 注释信息。这一点尤其重要，因为辣椒既含有 机会致病菌A. fumigaus以及模式遗传生物A. nidulans，和 对这些生物体进行研究将对人类健康产生积极影响。

The goal of this project is to develop a database, based on the software and schema used for the Saccharomyces and Candida Genome Databases, for the Aspergilli, wherein there will be data curated from the literature connected to specific genes. In curating the literature, we will record gene names and aliases, Gene Ontology annotations, and mutant phenotypes, as well as provide tools and interfaces for exploring the genome and its annotations. In addition, we will further develop and refine a robust, state-of-the-art genome annotation pipeline, and use this to perform primary genome annotation on each of the Aspergilli. This pipeline will take advantage of comparative genomic data between the Aspergilli, and will be re-run periodically, either when new data come to light (such as additional genomes), or when improved algorithms are incorporated into the pipeline. Thus, we will provide to the Aspergillus research community high quality literature based curation, coupled with the best possible primary annotation of each of the genomes. In this way, as has been done in other organism research communities, we will help to accelerate research into the Aspergilli, by enabling researchers to easily access relevant annotation information. This is particularly important, as the Aspergilli contain both the opportunistic pathogen, A. fumigaus, as well as the model genetic organism, A. nidulans, and enabling research into these organism will have a positive impact on human health.