Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs

描述（由申请人提供）：急性神经系统疾病，相对于其对社会的影响，已经非常少的研究。许多神经系统问题需要紧急评估和治疗，最好是由多学科团队进行。NETT网络的建立正是为了解决这些问题，因为发现和实施有效的神经系统紧急情况治疗方法将需要来自大规模临床试验的复杂研究方案。这一举措的成功不仅取决于协调良好的中央数据管理中心，还取决于有能力在大量人口中紧急招募患者的中心和分支站点。该计划的广泛和长期目标是测试和研究新的有效治疗神经系统紧急情况和改善美国人的整体健康。该项目的设计是一个中央协调“枢纽”（部。韦恩州立大学- WSU），该公司在急诊患者护理和基于急诊的临床试验方面具有公认的专业知识。“辐条”（底特律医疗中心和威廉博蒙医院）提供：i）从实验室到床边的神经科学专业知识，2）在紧急干预试验中招募患者的证明能力，3）覆盖密歇根州东南部的广泛人口统计中超过500，000次急诊科就诊，以及4）医院间，部门间和跨学科合作的悠久历史。罗伯特·韦尔奇博士与布赖恩·奥尼尔博士一起，拥有一个令人羡慕的合作团队，其中包括成人和儿童急诊医生、神经学家、神经外科医生、重症监护专家和创伤外科医生。WSU“中心”在院前启动的紧急干预试验方面拥有广泛的经验，并在急诊科，医院和康复阶段持续进行。WSU研究者已成功入组患者参加院前干预试验Res-Q、PAD、PolyHeme、DCAR、POST和脑血氧测定试验。此外，相同的研究者在各种紧急干预试验（如RESCUE、TIA-ADP、PECARN、ONO-REACT、BADHIT、Gen-IMS、PROACTION和RESCUE-ACS）中担任入组患者的领导者。在每项试验中，我们的研究中心都超出了预期，并为主要研究者提供了大量高质量的干净数据。其中一些研究需要与社区协商才能实施。WSU网站配备了一个集成的和先进的电子病历系统，连接医院网站。该系统具有先进的远程医疗能力，进一步增强了对患者的评估和咨询。NETT网络将进行研究，最终将导致新的和有效的治疗神经系统的紧急情况。这些新的治疗方法将传播给执业医生和他们的病人，并将改善公众的健康和生活。

DESCRIPTION (provided by applicant): Acute neurologic disorders, relative to their effect on society, have been very poorly studied. Many of these neurological problems require emergent evaluation and treatment, ideally by a multi-disciplinary team. The NETT network has been established to address just these issues as the discovery and implementation of effective treatments for neurological emergencies will require sophisticated study protocols derived from large-scale clinical trials. The success of this initiative hinges not only on a well-coordinated central data management center, but also on hub and spoke sites that have the competence to enroll patients emergently across a large demographic. The broad and long-term goal of this program is to test and institute new effective therapies for neurological emergencies and improve the overall health of Americans. The project design is that of a central coordinating "Hub" (Dept. of Emergency Medicine, Wayne State University - WSU) which has proven expertise in emergency patient care and emergency based clinical trails. The "Spokes" (Detroit Medical Center and William Beaumont Hospitals) offers: i) expertise in the neurosciences from the bench to the bedside, 2) proven competency in enrolling patients into emergent interventional trials, 3) over 500,000 emergency department visits across a wide demographic that blankets Southeast Michigan and 4) a long history of inter-hospital, interdepartmental and interdisciplinary collaboration. Dr Robert Welch, in conjunction with Dr. Brian O'Neil, has an enviable group of established collaborators that include both adult and pediatric emergency medicine physicians, neurologists, neurosurgeons, critical care specialists and trauma surgeons. The WSU "Hub" has a breadth of experience in emergent intervention trials initiated pre-hospital and continued throughout the emergency department, hospital and rehabilitation phases. WSU investigators have successfully enrolled patient in the pre-hospital interventional trials Res-Q, PAD, PolyHeme, DCAR, POST and Cerebral oximetry trials. Furthermore the same investigators have been leaders in enrolled patients in various emergent interventional trials such as RESCUE, TIA-ADP, PECARN, ONO-REACT, BADHIT, Gen-IMS, PROACTION, and RESCUE-ACS. In each of these trials our sites have exceeded expectations and provided high volume and high quality clean data to the principal investigators. A number of these studies required community consultation for implementation. The WSU site is equipped with an integrated and sophisticated electronic medical record system that links hospital sites. The system has advanced telemedicine capabilities, which further augments patient evaluations and consultation. The NETT Network will perform research studies that will ultimately result in new and effective treatment s of neurological emergencies. These new treatments will be disseminated to practicing doctors and their patients and will improve the health and lives of the public.