Animal Models Core
动物模型核心
基本信息
- 批准号:8379857
- 负责人:
- 金额:$ 16.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Animal ModelAnimalsAntineoplastic AgentsArchivesBiological AssayBreedingCancer PatientCaringCatalogingCatalogsCell SeparationCellsClinicalClinical ResearchComputer softwareCoupledCryopreservationDataDatabasesEmbryoEnsureEquipmentExcisionFetusFibroblastsFreezingGeneticGenotypeGrowthHealthHousingHumanImageImmunityIndividualInjection of therapeutic agentIntestinal CancerKnock-outKnockout MiceLiquid substanceLocationLongitudinal StudiesMalignant NeoplasmsMalignant neoplasm of gastrointestinal tractMalignant neoplasm of large intestineMedical GeneticsMissionModelingMolecularMusNitrogenNude MiceOnline SystemsOperating RoomsOperative Surgical ProceduresOutcomePancreasPartner in relationshipPatientsPharmaceutical PreparationsPharmacotherapyPredispositionPrimitive foregut structurePrintingProductionPublishingReactionRecordsResearchResearch PersonnelResearch Project GrantsResolutionRoleRunningSamplingScheduleServicesSiteSmall IntestinesSorting - Cell MovementSourceSpecific Pathogen FreesStomachTestingTissuesTransgenic MiceTransgenic ModelTransgenic OrganismsTranslational ResearchTumor TissueUltrasonographyUniversitiesWorkXenograft procedureblastocystchemotherapeutic agentcostefficacy testingembryonic stem cellgerm free conditionin vivomalignant stomach neoplasmmembermouse modelmutantneoplastic celloffspringprogramspupsperm celltissue preparationtumor
项目摘要
The Animal Models Core (AMC) will support all of the research projects in the program by providing the
necessary genetically modified mice and producing low-passage in vivo human gastro-intestinal cancer
explants in mice. One mission of the AMC will be to maintain mice for long-term studies to evaluate
predisposition to cancer. A second mission of the AMC will be maintaining stocks of the genetically modified
strains (e.g., elf, eif/Smad4, Smad4, Smad3, Cdk4-R24C mutant, cdk4 null mutant, htert knockout), and to
breed these strains together to produce fetuses of double and triple mutant homozygous genotypes. Working
with the Tissue Core B, these fetuses will be used as a source of embryonic fibroblasts and tumor cells by
the projects. Pups with the desired double or triple mutant genotypes will constitute a large fraction of the
progeny. To provide a continuous supply in support of the research projects a large amount of breeding,
coupled with genotype analysis to identify the appropriate individuals will be required. A third mission of the
AMC will be to provide synergy between the clinicians and projects testing anti-cancer drug therapies. This
synergy will be in the form of producing, and providing husbandry of mice harboring genetic backgrounds
predisposed to making tumors or nude mice xenografted with human tumor tissues for propagating lowpassage
tumors. All mice will be produced and housed under barrier conditions that ensure continuing
specific pathogen free status, Centralization of the production and care of these mice under the AMC will
limit the number of individuals handling the animals, thereby further safeguarding their health. Moreover, by
centralizing the production and dispensation of these genetically valuable animals, the animal core will be
able to coordinate usage among the different projects, avoid wastage, and achieve an economy of scale that
will permit these studies to be completed at less expense than if undertaken separately. A final mission of
the AMC will be to serve as a synergistic hub for all projects and cores.
动物模型核心(AMC)将为该计划中的所有研究项目提供支持
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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G IAN GALLICANO其他文献
G IAN GALLICANO的其他文献
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{{ truncateString('G IAN GALLICANO', 18)}}的其他基金
Using Cardiac Targeting Peptide to deliver miRNA for molecular reversal of heart failure
使用心脏靶向肽传递 miRNA 以分子逆转心力衰竭
- 批准号:
10481720 - 财政年份:2022
- 资助金额:
$ 16.59万 - 项目类别:
Investigating deskmoplakin during vasculogenesis
研究血管生成过程中的 deskmoplakin
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6574003 - 财政年份:2002
- 资助金额:
$ 16.59万 - 项目类别:
Investigating deskmoplakin during vasculogenesis
研究血管生成过程中的 deskmoplakin
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6685992 - 财政年份:2002
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Investigating deskmoplakin during vasculogenesis
研究血管生成过程中的 deskmoplakin
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6818777 - 财政年份:2002
- 资助金额:
$ 16.59万 - 项目类别:
Investigating deskmoplakin during vasculogenesis
研究血管生成过程中的 deskmoplakin
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6989775 - 财政年份:2002
- 资助金额:
$ 16.59万 - 项目类别:
FUNCTIONAL ANALYSIS: BAND 6 DURING MAMMALIAN DEVELOPMENT
功能分析:哺乳动物发育过程中的带 6
- 批准号:
2816005 - 财政年份:1998
- 资助金额:
$ 16.59万 - 项目类别:
FUNCTIONAL ANALYSIS: BAND 6 DURING MAMMALIAN DEVELOPMENT
功能分析:哺乳动物发育过程中的带 6
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2024970 - 财政年份:1997
- 资助金额:
$ 16.59万 - 项目类别:
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