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Restoring LV Function Post-MI Using Fibrin-Gel Based Engineered Myocardium

使用基于纤维蛋白凝胶的工程心肌恢复 MI 后左心室功能

基本信息

批准号：
8270013
负责人：
Lauren D. Black III
金额：
$ 24.9万
依托单位：
TUFTS UNIVERSITY MEDFORD
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-24 至 2014-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8270013
关键词：
Address Anatomy Area Arterial Fatty Streak Award Biological Biomedical Engineering Biomimetics Bioreactors Cardiac Cardiology Cardiovascular Diseases Cause of Death Cell Therapy Cells Communication Coronary artery Coupling Development Engineering Environment Evaluation Fibrin Funding Gel Goals Health Heart Heart Diseases Heart Transplantation Heart failure Human In Vitro Incidence Infarction Innovative Therapy Lead Learning Left Ventricular Function Left ventricular structure Mechanical Stimulation Mechanics Mentors Methods Modeling Molecular Morphology Muscle Cells Myocardial Myocardial Infarction Myocardial tissue Myocardium Natural regeneration Operative Surgical Procedures Patients Phase Physiological Physiology Positioning Attribute Property Rattus Research Research Institute Research Proposals Techniques Time Tissue Culture Techniques Tissue Engineering Tissue Grafts Tissues Universities Work base cardiac repair career comparative efficacy design functional restoration heart function implantation improved in vivo injured innovation prevent repaired skills

项目摘要

Cardiovascular disease can lead to myocardial infarction (Ml) and subsequent heart failure. There are currently a number of therapies aimed at preventing or treating heart failure post-MI. Only heart transplantation replaces infarcted myocardium to restore heart function, but there is a paucity of donor hearts and the incidence of cardiovascular disease continues to rise. A new and innovative option is the use of "heart patches" created in vitro for implantation in vivo. The research proposed in the independent phase of this award aims to address 2 critical issues pertaining to the function and eventual use of such heart patches: 1) the effect of a biomimetic culture environment on tissue morphology and function, and 2) the efficacy of myocardial equivalents biomimetically-engineered in vitro in restoring left ventricular function post-MI. The overall hypothesis of this work is that myocardium engineered in vitro in biomimetic culture conditions restores post-MI left ventricular function better than cell therapy-based methods of repair. The environment at the Tufts University uniquely positions me to address this hypothesis, as the world-renowned Tissue Engineering Research Center and Molecular Cardiology Research Institute are both located nearby. This environment will give me the opportunity to augment my already considerable background in tissue mechanics and tissue engineering methods with cardiac anatomy and physiology in health and disease and cardiac surgical techniques. The continuation of my career plan during the independent phase includes gaining more expertise in cell and tissue culture techniques and bioreactor development, while learning new skills in areas including cardiac surgical techniques and physiological evaluation in a rat model of Ml. The ultimate goal of the project is to leverage these skills to directly compare the efficacy of myocardial tissue engineered in vitro with current cell-therapy based methods of cardiac repair in restoring function to the left ventricle post-MI. This research is especially critical considering the continuing rise in incidence of heart disease. The results of this research may help elucidate design parameters that are critical to the creation of functional myocardium engineered in vitro and thus advance the concept of the "heart patch" closer to reality

心血管疾病可导致心肌梗死（Ml）和随后的心力衰竭。有