Hypertension in Pregnancy and Future Cardiovascular Disease

妊娠期高血压和未来的心血管疾病

• 批准号: 8367407
• 负责人: VIRGINIA M MILLER
• 金额: $ 26.22万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8367407
• 关键词: Address; Affect; Age; Biological; Blood Platelets; Blood Vessels; Brain; Cardiovascular Diseases; Cardiovascular system; Caring; Case-Control Studies; Chronic; Clinical; Cognition; Cognitive; Cohort Studies; County; Data; Dementia; Diagnosis; Diagnostic; Disease; Disease Outcome; Educational workshop; Epidemiologic Studies; Epidemiology; Female; Frequencies; Functional disorder; Future; Guidelines; Health; Heart Diseases; Heart failure; Hormones; Hypertension; Hypertension induced by pregnancy; Impaired cognition; Incidence; Life; Menopause; Morbidity - disease rate; Mothers; National Heart, Lung, and Blood Institute; Outcome; Pathogenesis; Patient Self-Report; Patients; Postpartum Period; Pre-Eclampsia; Pregnancy; Prevention; Proteinuria; Publishing; Recording of previous events; Records; Recruitment Activity; Reporting; Research; Residual state; Risk; Risk Factors; Sampling; Series; Sex Characteristics; Stroke; Subgroup; System; Testing; Time; Treatment Efficacy; Variant; Woman; base; cardiovascular risk factor; cerebrovascular; cognitive function; fetal; male; men; modifiable risk; mortality; neuroimaging; normotensive; outcome forecast; population based; pregnancy disorder; sex; treatment strategy

Cardiovascular epidemiologic research historically has focused on men, because male sex is one of the major risk factors for CVD. Consequently, numerous diagnostic and treatment strategies for CVD in women have been extrapolated from results of studies conducted in men, and sex-specific factors largely have been ignored. It became apparent in the 1980s that the decrease in cardiovascular mortality in men was not accompanied by a similar decrease in women. One of the reasons for this difference might be sex-based disparities in cardiovascular care; women have been both under evaluated for CVD and under treated for modifiable risk factors for CVD. In addition, female-specific conditions, such as hypertensive disorders of pregnancy, menopause, and hormone use, might affect the onset of CVD, its clinical course, the efficacy of therapy, and, ultimately, prognosis. This proposal responds to RFA-OD-11-003 by identifying complications of hypertensive pregnancy disorders as a major biological sex difference that may influence the future cardiovascular and cognitive health of the affected women. Results of the proposed research may open new venues for the prevention, diagnosis, and treatment of CVD and cognitive impairment in women.

心血管流行病学研究历来集中在男性，因为男性是主要的心血管疾病之一。 CVD的危险因素因此，许多女性CVD的诊断和治疗策略 根据对男性进行的研究结果推断，性别特异性因素在很大程度上被忽视。 在20世纪80年代，很明显，男性心血管死亡率的下降并不伴随着 在女性中也有类似的下降。造成这种差异的原因之一可能是基于性别的差异 在心血管护理方面;女性的心血管疾病评估不足， CVD的危险因素此外，女性特有的疾病，如妊娠期高血压疾病， 绝经和激素的使用，可能会影响CVD的发病，其临床过程，治疗的效果， 最后是预后。 本提案通过识别妊娠高血压疾病的并发症对RFA-OD-11-003做出响应 作为一个主要的生物性别差异，可能会影响未来的心血管和认知健康的人， 受影响的女性。拟议研究的结果可能为预防、诊断和治疗疾病开辟新的途径。 治疗女性心血管疾病和认知障碍。