Lifespan Psychosocial Profiles and Biological Pathways to Bone Strength

项目摘要/摘要 骨骼强度，或抵抗骨折的能力，在很大程度上取决于年轻和中年的骨骼健康 年轻时达到的峰值骨量越高，罹患骨质疏松症的可能性就越低。 晚年的骨质疏松。我们推测，影响寿命的社会和心理因素会影响骨骼 力量通过影响在青壮年达到的峰值力量水平，维持骨骼 中年时的体力，以及老年时的衰退率。我们的具体目标是： 目的1.确定长期的心理社会特征与骨强度之间的关联强度。 目的2.确定生物系统失调与骨强度之间的关联强度。 目的3.确定假定的生物学途径在多大程度上调节长-间的联系 术语心理社会特征和骨骼强度。 该项目将利用三项队列研究(美国的中年生活、威斯康星州的晚年生活研究 Resilience和麦克阿瑟成功老龄化研究)，这些数据来自24岁和 并有9年或更长时间的随访期。本项目针对本论文进行了独一无二的优化，原因如下：1) 除了使用标准的骨密度评估外，我们还将把骨健康结果扩展到 包括对骨骼强度和骨骼代谢平衡的全面评估。2)我们将确定 不仅有社会逆境和心理疾病的影响，也有社会优势和心理健康的影响 心理健康对骨骼结果的影响。3)将采用寿命视角，其中长期 心理社会影响将被用作成人骨强度的预测因子。 这个项目将是描述多重心理社会影响的第一次全面尝试。 在生命过程中(包括早期生命经历)关于骨强度的领域，并确定生物学 施加这些影响的途径。它的优势在于无与伦比的广度、深度和 3项队列研究中心理社会和生物学评估的纵向方面，互补性 在3项研究中评估骨骼结果的广度和深度，随访的时间长短，范围大 以及研究问题的新方法：采用更合适的生活方式-- 评估心理社会对骨强度影响的历史方法，同等考虑 心理社会优势和逆境，以及对骨骼强度的创新和综合评估， 这超出了通常的骨密度强度指标。

Project Summary/Abstract Bone strength, or the ability to resist fractures, is critically dependent on bone health in young and middle years - the higher the peak bone mass achieved in younger years, the lower the likelihood of developing osteoporosis in later life. We postulate that social and psychological factors over the lifespan affect bone strength by influencing the level of peak strength achieved in young adulthood, the maintenance of bone strength through middle adulthood, and the rate of decline in older ages. Our specific aims are to: Aim 1. Determine the strength of the association between long-term psychosocial profiles and bone strength. Aim 2. Determine the strength of the association between biological system dysregulation and bone strength. Aim 3. Determine the extent to which the putative biological pathways mediate the associations between long- term psychosocial profiles and bone strength. The project will draw on three cohort studies (Midlife in the United States, the Wisconsin Study of Late Life Resilience, and the MacArthur Study of Successful Aging) that together, have data from adults, ages 24 and up, and have 9 or more years of follow up. This project is uniquely optimized to explore this thesis because: 1) In addition to using standard bone mineral density assessments, we will expand bone health outcomes to include comprehensive assessments of bone strength and bone metabolic balance. 2) We will determine the influence not only of social adversity and psychological ill-health but also of social advantage and psychological well-being on bone outcomes. 3) A lifespan perspective will be adopted, wherein long-term psychosocial influences will be used as predictors of adult bone strength. This project will be the first comprehensive attempt to delineate the influences of multiple psychosocial domains over the life course (including early life experiences) on bone strength, and to identify the biological pathways through which these influences are exerted. Its strengths lie in the unmatched breadth, depth, and longitudinal aspect of psychosocial and biological assessments in the 3 cohort studies, the complementary breadth and depth of bone outcomes assessed across the 3 studies, the lengths of follow up, the large range of ages spanned, and the novel approach to the research questions: the adoption of the more appropriate life- history approach to estimating psychosocial influences on bone strength, the equal consideration given to psychosocial advantage and adversity, and the innovative and comprehensive assessment of bone strength, that goes beyond the usual bone density metric of strength.