Lifespan Psychosocial Profiles and Biological Pathways to Bone Strength

项目总结/摘要 骨强度，或抵抗骨折的能力，严重依赖于年轻人和中年人的骨骼健康。 年龄越大-在年轻时达到的峰值骨量越高， 老年骨质疏松症。我们假设在人的一生中社会和心理因素会影响骨骼 通过影响成年早期达到的峰值强度水平， 成年中期的力量，以及老年时的下降率。我们的具体目标是： 目标1。确定长期心理社会特征与骨强度之间的关联强度。 目标2.确定生物系统失调与骨强度之间的关联强度。 目标3。确定假定的生物学途径在多大程度上介导了长- 长期心理社会状况和骨强度。 该项目将借鉴三项队列研究（美国中年研究、威斯康星州老年研究 韧性，和麦克阿瑟成功老龄化研究），一起，有来自成年人的数据，年龄24岁， 并有9年或以上的随访。这个项目是独特的优化，以探讨这一论点，因为：1） 除了使用标准的骨矿物质密度评估，我们将扩大骨健康结果， 包括骨强度和骨代谢平衡综合评估。2)康贝特人将以 不仅受到社会逆境和心理疾病影响， 心理健康对骨骼结果的影响。3)将采用寿命观点，其中长期 心理社会影响将被用作成人骨强度的预测因子。 这个项目将是第一次全面的尝试，以描绘多种心理社会的影响， 领域的生命历程（包括早期的生活经验）对骨强度，并确定生物 这些影响是通过哪些途径发挥作用的。它的优势在于无与伦比的广度，深度， 3项队列研究中心理社会和生物学评估的纵向方面， 3项研究中评估的骨结局的宽度和深度、随访时间、大范围 的年龄跨度，和新的方法来研究问题：采用更适当的生活- 历史的方法来估计心理社会对骨强度的影响，给予平等的考虑， 心理社会优势和逆境，以及骨强度的创新和全面评估， 超过了通常的骨密度强度指标。

Project Summary/Abstract Bone strength, or the ability to resist fractures, is critically dependent on bone health in young and middle years - the higher the peak bone mass achieved in younger years, the lower the likelihood of developing osteoporosis in later life. We postulate that social and psychological factors over the lifespan affect bone strength by influencing the level of peak strength achieved in young adulthood, the maintenance of bone strength through middle adulthood, and the rate of decline in older ages. Our specific aims are to: Aim 1. Determine the strength of the association between long-term psychosocial profiles and bone strength. Aim 2. Determine the strength of the association between biological system dysregulation and bone strength. Aim 3. Determine the extent to which the putative biological pathways mediate the associations between long- term psychosocial profiles and bone strength. The project will draw on three cohort studies (Midlife in the United States, the Wisconsin Study of Late Life Resilience, and the MacArthur Study of Successful Aging) that together, have data from adults, ages 24 and up, and have 9 or more years of follow up. This project is uniquely optimized to explore this thesis because: 1) In addition to using standard bone mineral density assessments, we will expand bone health outcomes to include comprehensive assessments of bone strength and bone metabolic balance. 2) We will determine the influence not only of social adversity and psychological ill-health but also of social advantage and psychological well-being on bone outcomes. 3) A lifespan perspective will be adopted, wherein long-term psychosocial influences will be used as predictors of adult bone strength. This project will be the first comprehensive attempt to delineate the influences of multiple psychosocial domains over the life course (including early life experiences) on bone strength, and to identify the biological pathways through which these influences are exerted. Its strengths lie in the unmatched breadth, depth, and longitudinal aspect of psychosocial and biological assessments in the 3 cohort studies, the complementary breadth and depth of bone outcomes assessed across the 3 studies, the lengths of follow up, the large range of ages spanned, and the novel approach to the research questions: the adoption of the more appropriate life- history approach to estimating psychosocial influences on bone strength, the equal consideration given to psychosocial advantage and adversity, and the innovative and comprehensive assessment of bone strength, that goes beyond the usual bone density metric of strength.