IPT and Antipsychotic Dose Reduction for Youth with Severe Mood Dysregulation

描述(由申请人提供)：拟议的计划推进了候选人的长期目标，即实施心理社会干预作为药物治疗的辅助治疗，目的是减轻患有情绪障碍的青少年的药物负担。该奖项专门针对患有严重情绪失调(SMD)的青少年。职业发展活动包括发展以下方面的专门知识：1)患有SMD和其他情绪障碍的青少年的诊断评估；2)临床试验数据分析的生物统计学；3)干预研究的设计、开发和实施；4)抑郁青少年的人际心理治疗(IPT-A)和相关适应。在拟议的研究中，IPT-A将适用于患有SMD的青年(IPT-SMD)。在进行了5个试点病例后，候选人将进行主要研究，其中患有SMD的青年将被随机分为IPT-SMD治疗组或照常治疗(TAU)组。在第10周，那些BPRS-C得分改善30%的年轻人将慢慢减少抗精神病药物的治疗。对青少年进行为期24周的跟踪调查。拟议奖项的总体目标是为候选人在更大规模的随机对照试验中成功提交衡量IPT-SMD疗效的申请做好准备。

DESCRIPTION (provided by applicant): The proposed plan advances the candidate's long-term goal of implementing psychosocial interventions as adjunctive treatment to pharmacotherapy with the goal of reducing medication burden for youth with mood disorders. This award is specifically focused on youth with severe mood dysregulation (SMD). Career development activities include developing expertise in: 1) the diagnostic assessment of youth with SMD and other mood disorders; 2) biostatistics for the analysis of clinical trial data; 3) intervention study design development and implementation; 4) Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) and relevant adaptations. For the proposed study, IPT-A will be adapted for youth with SMD (IPT-SMD). After conducting 5 pilot cases, the candidate will carry out the main study wherein youth with SMD will be randomized to treatment with IPT-SMD or treatment as usual (TAU). At week 10, those youth with a 30% improvement in BPRS-C scores will be slowly tapered off antipsychotic medication. Youth will be followed for 24 weeks. The overall goal of the proposed award is to prepare the candidate for a successful submission of an application measuring the efficacy of IPT-SMD in a larger randomized controlled trial.