IPT and Antipsychotic Dose Reduction for Youth with Severe Mood Dysregulation

针对严重情绪失调青少年的 IPT 和抗精神病药物剂量减少

• 批准号: 8454535
• 负责人: Leslie Rachel Miller
• 金额: $ 18.31万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8454535
• 关键词: Adolescent; Am 80; Antipsychotic Agents; Award; Biometry; Child; Clinical Trials; Data; Depressed mood; Development; Diagnostic; Dose; Effectiveness; Eligibility Determination; Funding; Future; Goals; Human Resources; Intervention; Intervention Studies; Measures; Metabolic; Monitor; Mood Disorders; Moods; Morbidity - disease rate; Parents; Participant; Pharmaceutical Preparations; Pharmacotherapy; Psychopathology; Psychotherapy; Published Comment; Randomized; Randomized Controlled Trials; Research Design; Teenagers; United States National Institutes of Health; Youth; arm; career development; clinically relevant; improved; multi-site trial; post intervention; psychosocial; satisfaction; treatment as usual

DESCRIPTION (provided by applicant): The proposed plan advances the candidate's long-term goal of implementing psychosocial interventions as adjunctive treatment to pharmacotherapy with the goal of reducing medication burden for youth with mood disorders. This award is specifically focused on youth with severe mood dysregulation (SMD). Career development activities include developing expertise in: 1) the diagnostic assessment of youth with SMD and other mood disorders; 2) biostatistics for the analysis of clinical trial data; 3) intervention study design development and implementation; 4) Interpersonal Psychotherapy for Depressed Adolescents (IPT-A) and relevant adaptations. For the proposed study, IPT-A will be adapted for youth with SMD (IPT-SMD). After conducting 5 pilot cases, the candidate will carry out the main study wherein youth with SMD will be randomized to treatment with IPT-SMD or treatment as usual (TAU). At week 10, those youth with a 30% improvement in BPRS-C scores will be slowly tapered off antipsychotic medication. Youth will be followed for 24 weeks. The overall goal of the proposed award is to prepare the candidate for a successful submission of an application measuring the efficacy of IPT-SMD in a larger randomized controlled trial.

描述（由申请人提供）：拟议的计划推进了候选人的长期目标，即实施心理社会干预措施作为药物治疗的替代治疗，目的是减少情绪障碍青年的药物负担。 该奖项特别关注患有严重情绪失调（SMD）的青少年。 职业发展活动包括发展以下方面的专业知识：1）SMD和其他情绪障碍青年的诊断评估; 2）临床试验数据分析的生物统计学; 3）干预研究设计开发和实施; 4）抑郁青少年的人际心理治疗（IPT-A）和相关适应。 对于拟议的研究，IPT-A将适用于SMD青年（IPT-SMD）。 在进行5个试点病例后，候选人将进行主研究，其中SMD青年将随机接受IPT-SMD治疗或常规治疗（TAU）。 在第10周，那些BPRS-C评分改善30%的青少年将慢慢减少抗精神病药物。青年将被跟踪24周。该奖项的总体目标是为候选人成功提交申请做好准备，以在更大规模的随机对照试验中测量IPT-SMD的疗效。