Infants at Risk of Autism: A Longitudinal Study

项目摘要/摘要 这项应用是对高危婴儿的纵向研究的竞争性更新。 孤独症(R01 MH068398，7/1/03-6/30/08)。在第一个五年的资助中，一个跨站点 研究(加州大学戴维斯分校和加州大学洛杉矶分校)对180名自闭症儿童的兄弟姐妹进行了研究 与90名发育正常的儿童的兄弟姐妹进行了比较 行为任务测量对自闭症早期表型很重要。在……里面 本次竞争续签，我们要求追加经费招募新的婴幼儿样本 并在进入学校时纵向遵循最初的样本。基于 我们之前的研究发现，6个月和12个月的行为症状几乎没有差异 年龄，新样本使用的实验测量将重点放在潜在的 可能揭示高危儿童在行为障碍发作前的差异的过程 有混乱的迹象。将继续与加州大学洛杉矶分校就新样本和 对上一次样本进行纵向随访。具体目标是： 目标1：确定可靠的标记物来区分患有自闭症或自闭症的儿童结果 来自有其他发育迟缓或没有发育迟缓的儿童，检查两种症状的出现 以及潜在的潜在机制，以了解轨迹何时偏离以及在什么情况下偏离 领域(研究1：新确定的婴儿兄弟姐妹样本)。 目的2：在前一奖项招募的自闭症儿童的兄弟姐妹样本中 期间，检查自闭症和PDDNOS诊断的稳定性并识别后来出现的 通过评估6岁时的功能来评估发育问题(研究2：纵向随访 上一次婴儿同胞样本的增加)。

PROJECT SUMMARY/ABSTRACT This application is a competitive renewal of a longitudinal study of infants at risk for autism (R01 MH068398, 7/1/03 - 6/30/08). In the first five years of funding, a cross-site study (UC Davis and UCLA) was conducted in which 180 siblings of children with autism were compared to 90 siblings of children with typical development on a wide array of behavioral tasks measuring constructs important to the very early autism phenotype. In this competitive renewal, we request additional funds to recruit a new sample of infant siblings and to follow longitudinally the original sample as they enter school. Based on our previous findings of few differences in behavioral symptoms at 6 and 12 months of age, experimental measures used with the new sample will focus on underlying processes that may reveal differences in at-risk children prior to the onset of behavioral signs of disorder. Collaboration with UCLA will continue for both the new sample and the longitudinal follow-up of the previous sample. Specific aims are to: AIM 1: Identify reliable markers that differentiate children with autism or ASD outcomes from children with other or no developmental delays, examining both onset of symptoms and potential underlying mechanisms to see when trajectories diverge and in what domains (Study 1: newly ascertained infant sibling sample). AIM 2: In the sample of siblings of children with autism recruited in the prior award period, examine stability of autism and PDDNOS diagnoses and identify later-appearing developmental problems by assessing functioning at age 6 (Study 2: longitudinal follow up of previous infant sibling sample).