The Moderating Influence of Personality on Cognitive Stimulation Outcomes in Pers
人格对个体认知刺激结果的调节影响
基本信息
- 批准号:8249579
- 负责人:
- 金额:$ 3.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-02-15 至 2015-02-14
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAffectAlzheimer&aposs DiseaseAttentionBehavior TherapyBrainCaregiver BurdenCaregiversCaringCharacteristicsChronic DiseaseClinicalCognitionCognitiveCognitive deficitsConfusionControl GroupsDataData AnalysesDeliriumDementiaDevelopmentDiagnosisDisease OutcomeEffectivenessEffectiveness of InterventionsElderlyEnrollmentEquipment and supply inventoriesFeelingFoundationsFundingHealthHealth Care CostsHospitalizationImpaired cognitionIndividualInstitutionalizationInterventionIntervention StudiesKnowledgeLiteratureMeasuresMemoryModelingMorbidity - disease rateMotivationMultiple Personality DisorderNatureNeurobehavioral ManifestationsNeurotic DisordersNursing HomesOutcomePennsylvaniaPerformancePersonal SatisfactionPersonalityPersonality AssessmentPersonality TraitsPersonsPharmaceutical PreparationsPopulationQuality of lifeRandomizedRandomized Controlled TrialsRehabilitation therapyResearchResearch PersonnelSamplingStructureTestingTherapeuticThinkingTimeUnited StatesUnited States National Institutes of HealthVulnerable Populationsabstractingaging populationbasecognitive changecognitive functionexecutive functionexperiencehigh riskimprovedinattentioninformantinstrumentintervention effectintervention programloved onesmortalitynondrug therapypreferencepreventrehabilitation servicestressorsuccesstreatment adherencetreatment as usualtreatment effect
项目摘要
DESCRIPTION (provided by applicant): Cognitive decline due to dementia is a significant threat to the health and well-being of many older adults. As a consequence of its progressive nature, dementia inevitably leads to devastating declines in quality of life. Cognition- focused behavioral interventions which target compensatory brain mechanisms in order to improve cognitive performance have been tested in this population with promising results; researchers have yet to address why some individuals are better candidates than others. The proposed research will extend scientific knowledge regarding cognition-focused interventions by investigating the moderating effect of personality on a cognition-focused intervention in individuals with dementia at high risk for accelerated cognitive decline. The specific aims of the proposed study are as follows: 1) To test the moderating effect of personality traits on the relationship between a cognitive stimulation intervention and improvement in five domains of cognitive function (attention, memory, orientation, executive functioning, and abstract thinking) during a period of abrupt cognitive decline; and, 2) To test the moderating effect of personality traits on engagement in the intervention during a period of abrupt cognitive decline. This research will utilize a portion of the sample currently participating in a randomized clinical tria testing the effectiveness of individualized cognitively stimulating activities. Subjects are recruied from five nursing homes in Pennsylvania with post-acute care services for rehabilitation following hospitalization. Those enrolled during a two year period, or an estimated 120 total subjects, will be included in the proposed study. All subjects are screened for the presence of mild to moderate dementia as well as the presence of delirium, a state of acute confusion characterized by inattention. Acute confusion in an already cognitively vulnerable population provides an opportunistic model for viewing the effects of the intervention, including the influence of moderating factors, during the course of rehabilitation. Eligible subjects are randomized to treatment and control groups. The intervention consists of a variety of individually tailored cognitively stimulating recreational activities which are delivered for 30 minutes a day for up to 30 days; the control group receives usual care. The Principle Investigator of the proposed study will collect personality assessment data using the informant version of the NEO Five Factor Inventory, a well-established and commonly used instrument based on the five factor model of personality. Cognitive function in the five targeted domains will be measured each day in both groups. Engagement in the intervention will be measured as both time on task and level of participation. A linear mixed-effects model will be applied for data analysis. Each of
the five personality traits will be tested independently for a statistically significant moderating
effect on each domain of cognitive functioning, as well as separately for a moderating effect on engagement in the intervention. Interactions between multiple personality traits will also be considered within the model. Existing research has not investigated the potential moderating influence of individual characteristics on the treatment effect of cognitive stimulating activitiesin individuals experiencing cognitive decline. The proposed research will address that critical gap and help build a strong foundation for tailored cognition-focused intervention research.
PUBLIC HEALTH RELEVANCE: The onset of dementia heralds a downward spiral of cognitive decline that is devastating to those diagnosed as well as to their caregivers and other loved ones. Effective non-drug treatments to improve cognitive functioning in these individuals may promote independence, improve quality of life, reduce caregiver burden, prevent institutionalization, and reduce healthcare costs. This study will examine how personality may help identify individuals who are best candidates for specific non-drug treatments.
描述(由申请人提供):痴呆症引起的认知能力下降对许多老年人的健康和福祉构成重大威胁。由于其渐进性,痴呆症不可避免地导致生活质量的毁灭性下降。以认知为重点的行为干预措施,目标是补偿大脑机制,以提高认知能力,已经在这一人群中进行了测试,结果令人鼓舞;研究人员尚未解决为什么有些人比其他人更好。拟议的研究将通过调查人格对加速认知衰退高风险痴呆症患者认知干预的调节作用,扩展有关认知干预的科学知识。本研究的具体目的如下:1)检验人格特质对认知刺激干预与五个认知功能领域改善之间关系的调节作用(注意力、记忆力、定向力、执行功能和抽象思维);(2)在认知功能突然下降的情况下,检验人格特质对干预参与的调节作用。本研究将利用目前参与随机临床试验的一部分样本,测试个性化认知刺激活动的有效性。受试者从宾夕法尼亚州的五家疗养院招募,在住院后进行急性后护理服务以进行康复。在两年期间入组的受试者或估计总共120例受试者将被纳入拟定研究。对所有受试者进行筛选,以确定是否存在轻度至中度痴呆以及是否存在谵妄,谵妄是一种以注意力不集中为特征的急性意识模糊状态。急性混乱已经认知脆弱的人群提供了一个机会主义的模型,观察干预的效果,包括调节因素的影响,在康复过程中。将合格受试者随机分配至治疗组和对照组。干预包括各种个性化定制的认知刺激娱乐活动,每天30分钟,长达30天;对照组接受常规护理。拟议研究的主要研究者将使用NEO五因素量表的信息提供者版本收集人格评估数据,这是一种基于人格五因素模型的成熟和常用工具。每天将测量两组中五个目标领域的认知功能。 参与干预的程度将以完成任务的时间和参与程度来衡量。将采用线性混合效应模型进行数据分析。中的每
这五种人格特质将被独立地测试,以获得统计学上显著的调节作用。
对认知功能的每个领域的影响,以及分别对干预参与的调节作用。模型中还将考虑多种人格特质之间的相互作用。现有的研究尚未调查个体特征对认知刺激活动治疗认知衰退个体效果的潜在调节作用。拟议的研究将解决这一关键差距,并有助于为量身定制的以认知为重点的干预研究奠定坚实的基础。
公共卫生相关性:痴呆症的发作预示着认知能力下降的螺旋式下降,这对被诊断的人以及他们的照顾者和其他亲人都是毁灭性的。有效的非药物治疗,以改善这些人的认知功能,可以促进独立,提高生活质量,减少照顾者的负担,防止机构化,并降低医疗费用。这项研究将探讨个性如何帮助确定哪些人是特定非药物治疗的最佳候选人。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Nikki L. Hill其他文献
Nikki L. Hill的其他文献
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{{ truncateString('Nikki L. Hill', 18)}}的其他基金
Alzheimer's disease risk factors as mediators of subjective memory impairment and objective memory decline: A construct-level replication across four studies
阿尔茨海默病风险因素作为主观记忆损伤和客观记忆下降的中介:四项研究的构建水平复制
- 批准号:
9284015 - 财政年份:2017
- 资助金额:
$ 3.08万 - 项目类别:
Alzheimer's disease risk factors as mediators of subjective memory impairment and objective memory decline: A construct-level replication across four studies
阿尔茨海默病风险因素作为主观记忆损伤和客观记忆下降的中介:四项研究的构建水平复制
- 批准号:
9914163 - 财政年份:2017
- 资助金额:
$ 3.08万 - 项目类别:
The Moderating Influence of Personality on Cognitive Stimulation Outcomes in Pers
人格对个体认知刺激结果的调节影响
- 批准号:
8444818 - 财政年份:2012
- 资助金额:
$ 3.08万 - 项目类别:
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