Improving on nature: diversifying glycopeptide antibiotics to kill the bacterial pathogen Staphylococcus aureus

改善自然：多样化糖肽抗生素杀死细菌病原体金黄色葡萄球菌

• 批准号: nhmrc : GNT1140619
• 负责人: A/Pr Max Cryle
• 金额: $ 47.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/improving-nature-diversifying-staphylococcus-aureus/1348318
• 关键词: Improving; nature; diversifying; glycopeptide; antibiotics

Many bacteria have become resistant to existing antibiotics and we are badly in need of new antibiotics and strategies to combat them. My research centres on the class of antibiotics that includes the last resort therapy vancomycin. I aim to (1) develop novel ways to kill bacteria with these antibiotics and (2) understand and re-engineer the ways in which these antibiotics are produced. This will allow my team will develop new antibiotics to kill dangerous bacteria such as Staphylococcus aureus.

许多细菌已经对现有的抗生素产生了耐药性，我们迫切需要新的抗生素和策略来对抗它们。我的研究集中在抗生素的种类上，包括万古霉素的最后疗法。我的目标是：(1)开发出用这些抗生素杀死细菌的新方法；(2)了解并重新设计这些抗生素的生产方式。这将允许我的团队开发新的抗生素来杀死危险的细菌，如金黄色葡萄球菌。