Engineering Nature-based Solutions to Tackle Antimicrobial Resistance

工程基于自然的解决方案来解决抗菌素耐药性

• 批准号: EP/Y003101/1
• 负责人: Tao Lyu
• 金额: $ 21.05万
• 依托单位: CRANFIELD UNIVERSITY
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FY003101%2F1
• 关键词: Engineering; Nature; based; Solutions; Tackle

A global survey showed that nearly 10 million people could die each year as a result of antimicrobial resistance (AMR) if the situation is left unchanged. The UK is at the forefront of the global fight against AMR and setting the vision to contain and control AMR by 2040. With reference to the World Health Organisation (WHO) AMR action plan, the global AMR surveillance programme is conducted to understand trends, monitor interventions and develop empiric treatment guidelines for AMR. However, in the water sector, this AMR surveillance effort mainly focuses on conventional treatment stages and does not include nature-based solutions (NbS) infrastructures. Defra's 25-Year Environment Plan, the Water Industry's National Environment Programme, and the Environment Agency 2025 Plan have created a unique opportunity to consider constructed wetlands (CWs) as NbS to deliver wastewater treatment with the provision of environmental and societal co-benefits. All water utilities have deployed their strategies to further promote CWs in sewage works. Therefore, understanding if CW, as an emerging preferred green approach for tertiary treatment in wastewater treatment plants, can act as the final safeguard of natural waters to mitigate such risks while maintaining the contribution of co-benefits is crucial.The experience and lessons learned from the global AMR action could significantly facilitate the current missing NbS focus area on AMR surveillance. Partner Prof Walsh has worked with the WHO on the AMR surveillance programme and the European Joint Programme with a specific focus on AMR. Her expertise and experience will strengthen this project team with key knowledge of the occurrence, transmission, and removal mechanisms of AMR. The AMR investigation in NbS is recently getting attention but suffers from a lack of international-scale assessment with a limited dataset. Partner Dr Carvalho is working on the EU NATURE project to evaluate AMR removal in different CWs from mainland Europe, and the findings will be shared with this project.In this project, PI Dr Lyu will conduct the first field survey in the UK to collect evidence from four different applied CWs in England and Wales with the support of two industrial partners (Anglian Water and Welsh Water). Together with available datasets from the literature and the project partners' network, this project will conduct an international comparative study of AMR removal in CWs as NbS for wastewater treatment. Moreover, the team will also assess the undervalued contribution of reactive oxygen species and indicate adaptations of CWs toward promoting rhizosphere-activated free radicals to oxidise AMR. Ultimately, this project aims to establish a unique collaborative partnership between international academics and industrial practitioners, through sharing experiences, discovering knowledge gaps, exploring technology innovation, and supporting evidence-based policymaking, toward developing a resilient wastewater treatment infrastructure based on NbS to mitigate the spread of AMR.

一项全球调查显示，如果情况保持不变，则每年将有近1000万人因抗菌耐药性（AMR）而死亡。英国处于反对AMR斗争的最前沿，并设定了到2040年遏制和控制AMR的愿景。参考世界卫生组织（WHO）AMR行动计划，全球AMR监视计划的实施旨在了解趋势，监测干预措施并制定AMR的经验治疗指南。但是，在水部门，这种AMR监视工作主要集中于常规治疗阶段，不包括基于自然的解决方案（NBS）基础设施。 Defra的25年环境计划，水工业的国家环境计划和2025年环境局计划为将建造的湿地（CWS）视为NBS提供了独特的机会，可以通过提供环境和社会共同利益来提供废水处理。所有水公用事业都采用了策略来进一步促进污水处理工程中的CW。因此，理解CW作为新兴的废水处理厂中新兴的三级治疗方法，是否可以作为自然水域的最终保障措施，以减轻这种风险，同时保持共同利益的贡献至关重要。从全球AMR行动中汲取的经验和经验可能会显着促进当前缺失的NBS amr serve comr serve comr serve comr serve comr serve。合作伙伴沃尔什（Walsh）教授曾与WHO中的AMR监视计划和欧洲联合计划合作，专门针对AMR。她的专业知识和经验将通过对AMR的发生，传输和删除机制的重要了解来增强该项目团队。 NBS中的AMR调查最近引起了人们的关注，但由于数据集有限，缺乏国际规模的评估。合作伙伴Carvalho博士正在研究欧盟自然项目，以评估来自欧洲大陆的不同CW中的AMR删除，并将与该项目共享研究结果。在该项目中，Pi Lyu将在英国进行首次现场调查，以收集英格兰和威尔士的四个不同应用的CWS的证据，并支持两个工业伙伴（Anglian Water和Welsh Water和Welsh Water和Welsh Water）。该项目将与文献和项目合作伙伴网络的可用数据集一起进行国际比较研究，以作为废水处理的CWS中的AMR去除。此外，该团队还将评估活性氧的低估贡献，并表明CWS对促进根际激活的自由基对氧化AMR的适应。最终，该项目旨在通过共享经验，发现知识差距，探索技术创新和支持基于证据的决策，以开发基于NBS基于NBS的弹性废水治疗基础架构来减轻AMR的传播，从而建立国际学者与工业从业人员之间的独特合作伙伴关系。