MSU Short Course in Integrative Pharmacology

描述(由申请人提供)：研究表明，具有体内系统工作经验的综合生理学家、药理学家和毒物学家的培训有所下降。密歇根州立大学综合和器官系统药理学短期课程的目标是培养高级研究生和其他从事药理学工作的学生，使他们具备设计和实施体内研究以及评估器官系统功能以确定药物作用所必需的知识和技能。该计划建立在三个基石上：动手实验室经验、实验室演示和互动讲座。互动讲座将集中于疾病的动物模型、药理学和毒理学的当前主题，以及综合科学的实用知识。将特别强调在使用动物以及实验设计和统计分析方面的研究中负责任的行为。该计划的范围很广，从心血管到行为药理学和肿瘤学。这门课程将利用密歇根州立大学和密歇根其他机构的教职员工以及来自全国各地的同事的专业知识，他们将为该项目的学生提供专业知识。学生们将被吸引到密歇根州立大学在夏季为期两周的时间进行这门强化课程。将在培训计划期间和之后进行详细的评估过程，以便每年都能做出适当的改变。完成后，成功的学生将拥有知识和技能，以采用有效的策略来解决综合药理学的问题。公共卫生相关性：该计划将帮助解决研究生培训中的一个重要需求，使学生具备设计和进行整个动物和器官系统药理学研究所需的理解和技能。随着遗传学、分子和细胞方法的出现，学生们失去了在课程中获得与研究动物一起工作的实践培训经验的机会。随着与转基因动物相关的表型评估的需要以及新药的开发和安全性的需要，这些技能的需求越来越大。

DESCRIPTION (provided by applicant): Studies have indicated a decline in the training of integrative physiologists, pharmacologists, and toxicologists with experience in working with in vivo systems. The goal of the MSU-Short Course in Integrative and Organ Systems Pharmacology is to prepare advanced graduate students and others working in pharmacological sciences with the knowledge and skills necessary to design and implement in vivo studies and assess organ system function to determine drug actions. The program is built upon three cornerstones: hands-on laboratory experiences, laboratory demonstrations, and interactive lectures. The interactive lectures will focus on animal models of disease, current topics in pharmacology and toxicology, and practical knowledge for integrative sciences. Special emphasis will be placed on responsible conduct in research regarding the use of animals and experimental design and statistical analysis. The program is broad in scope ranging from cardiovascular to behavioral pharmacology and oncology. The course will draw upon the expertise of faculty at Michigan State University, other institutions in Michigan, and colleagues from around the country who will provide specialized knowledge for the students in the program. Students will be attracted to Michigan State University for a two week period in the summer for this intensive course. A detailed evaluation process will occur during and after the training program so that appropriate changes can be made from year to year. Upon completion, the successful students will have the knowledge and skills to employ an effective strategy in addressing problems in integrative pharmacology. PUBLIC HEALTH RELEVANCE: This program will help address a vital existing need in graduate training to prepare students with an understanding and the skills necessary to design and conduct whole animal and organ system pharmacological studies. With the advent of genetic, molecular and cellular approaches, students have lost the opportunity in their curriculum to have the hands-on training experience of working with research animals. With the need for the assessment of phenotypes associated with transgenic animals and the development and safety of new drugs, these skills are in ever greater demand.