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Nebraska Center for Cellular Signaling

内布拉斯加州细胞信号中心

基本信息

批准号：
8300188
负责人：
KEITH R JOHNSON
金额：
$ 195.9万
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-19 至 2013-09-04
项目状态：
已结题

项目摘要

This COBRE application proposes to continue The Nebraska Center for Cellular Signaling that was established to strengthen the research within UNMC and particularly the College of Dentistry. The stated objectives of the Center were 1) to expand the current focus on cellular signaling; 2) to increase the research profile of Nebraska's dental schools, with the ultimate goal of being included in the top dental schools in the country in NIH funding; and, most importantly, 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. We have accomplished each of these goals with exceptional successful: We have created the necessary infrastructure consisting of 1) An organized Center comprised of a committed director, an outstanding External Advisory Board, and a group of highly dedicated Mentors, and 2) a program of development, designed to enhance and sustain the Center, that includes a seminar program, graduate student stipends and a seed grant program. With this in place, we have attracted highly talented and driven junior Project Leaders investigating inter-related research projects focused on a variety of aspects of cellular signaling, and covering disease states from developmental problems to cancer. As evidence of our success, we have supported 14 junior Project Leaders and have seen five of them funded through the NIH R01 mechanism, with two more expected to be funded in the next funding cycle. In addition, our junior Project Leaders have published or have in preparation 65 papers and manuscripts. Three of our Project Leaders serve on review panels at the NIH, Department of Defense and American Heart Association, and several have been invited speakers at national and international conferences. We have strong support from the institution and a plan in place to sustain the program when the CoBRE funding expires. The PI and mentors involved in this project are committed to continuing a culture of mentoring within UNMC. In addition, the collaborative environment resulting from the formation of the Center has and will continue to enhance the research infrastructure within Nebraska's Dental and Medical Schools.

这项Cobre申请建议继续内布拉斯加州细胞信号中心，该中心的建立是为了加强UNMC内的研究，特别是牙科学院。该中心宣布的目标是1)扩大目前对细胞信号的关注；2)提高内布拉斯加州牙科学校的研究知名度，最终目标是被纳入NIH资助的全国一流牙科学校；以及最重要的是，3)促进有前途的年轻教师的发展，这样他们将成为科学界的杰出成员，NIH的巨额资金、发表重要手稿、审查小组服务和在全国各地演讲的邀请就是证明。我们已经非常成功地实现了这些目标中的每一个：我们创建了必要的基础设施，包括1)由一名坚定的董事、一个杰出的外部顾问委员会和一群高度敬业的导师组成的有组织的中心，以及2)旨在加强和维持该中心的发展计划，其中包括研讨会计划、研究生津贴和种子资助计划。有了这一点，我们吸引了才华横溢、干劲十足的初级项目负责人研究相互关联的研究项目，重点关注细胞信号的各个方面，并涵盖从发育问题到癌症的各种疾病状态。作为我们成功的证据，我们支持了14名初级项目负责人，并看到其中5人通过NIH R01机制获得资金，预计下一个供资周期还将有另外两人获得资金。此外，我们的初级项目负责人已经发表或正在准备65篇论文和手稿。我们的三名项目负责人在美国国立卫生研究院、国防部和美国心脏协会的审查小组任职，其中几人被邀请在国内和国际会议上发言。我们得到了该机构的大力支持，并制定了在Cobre资金到期时维持该计划的计划。参与这一项目的非政府组织和导师致力于在军事管理委员会内继续培养一种指导文化。此外，该中心形成的协作环境已经并将继续加强内布拉斯加州牙科和医学院的研究基础设施。

项目成果

期刊论文数量（18）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential.

DOI：
10.1007/s12672-016-0268-z
发表时间：
2016-08
期刊：
Hormones & cancer
影响因子：
3
作者：
Zimmer BM;Howell ME;Wei Q;Ma L;Romsdahl T;Loughman EG;Markham JE;Seravalli J;Barycki JJ;Simpson MA
通讯作者：
Simpson MA

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.