Nebraska Center for Cellular Signaling

内布拉斯加州细胞信号中心

• 批准号: 7920725
• 负责人: KEITH R JOHNSON
• 金额: $ 40万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-23 至 2011-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7920725
• 关键词: Nebraska; Center; Cellular; Signaling

DESCRIPTION (provided by applicant): This COBRE application proposes to continue The Nebraska Center for Cellular Signaling that was established to strengthen the research within UNMC and particularly the College of Dentistry. The stated objectives of the Center were 1) to expand the current focus on cellular signaling; 2) to increase the research profile of Nebraska's dental schools, with the ultimate goal of being included in the top dental schools in the country in NIH funding; and, most importantly, 3) to contribute to the development of promising young faculty, so that they will become prominent members of the scientific community as evidenced by significant NIH funding, publication of important manuscripts, service on review panels and invitations to speak across the country. We have accomplished each of these goals with exceptional successful: We have created the necessary infrastructure consisting of 1) An organized Center comprised of a committed director, an outstanding External Advisory Board, and a group of highly dedicated Mentors, and 2) a program of development, designed to enhance and sustain the Center, that includes a seminar program, graduate student stipends and a seed grant program. With this in place, we have attracted highly talented and driven junior Project Leaders investigating inter-related research projects focused on a variety of aspects of cellular signaling, and covering disease states from developmental problems to cancer. As evidence of our success, we have supported 14 junior Project Leaders and have seen five of them funded through the NIH R01 mechanism, with two more expected to be funded in the next funding cycle. In addition, our junior Project Leaders have published or have in preparation 65 papers and manuscripts. Three of our Project Leaders serve on review panels at the NIH, Department of Defense and American Heart Association, and several have been invited speakers at national and international conferences. We have strong support from the institution and a plan in place to sustain the program when the COBRE funding expires. The PI and mentors involved in this project are committed to continuing a culture of mentoring within UNMC. In addition, the collaborative environment resulting from the formation of the Center has and will continue to enhance the research infrastructure within Nebraska's Dental and Medical Schools.

描述（由申请人提供）：此 COBRE 申请建议继续建立内布拉斯加州细胞信号传导中心，该中心的建立是为了加强 UNMC 特别是牙科学院的研究。该中心的既定目标是 1) 扩大当前对细胞信号传导的关注； 2) 提高内布拉斯加州牙科学校的研究知名度，最终目标是跻身美国国立卫生研究院资助的顶尖牙科学校行列；最重要的是，3）为有前途的年轻教师的发展做出贡献，使他们成为科学界的杰出成员，这体现在 NIH 的大量资助、重要手稿的出版、审查小组的服务和全国各地演讲的邀请上。 我们非常成功地实现了其中的每一个目标：我们创建了必要的基础设施，包括：1）一个有组织的中心，由一位忠诚的董事、一个杰出的外部顾问委员会和一组高度敬业的导师组成；2）一个旨在加强和维持中心的发展计划，其中包括研讨会计划、研究生津贴和种子资助计划。有了这个，我们吸引了才华横溢、有干劲的初级项目负责人，他们调查相互关联的研究项目，重点关注细胞信号传导的各个方面，涵盖从发育问题到癌症的疾病状态。作为我们成功的证据，我们支持了 14 名初级项目负责人，其中 5 名通过 NIH R01 机制获得资助，另外两名预计将在下一个资助周期获得资助。此外，我们的初级项目负责人已发表或正在准备 65 篇论文和手稿。我们的三位项目负责人在美国国立卫生研究院、国防部和美国心脏协会的审查小组中任职，其中几位已受邀在国内和国际会议上发表演讲。 我们得到了该机构的大力支持，并制定了在 COBRE 资金到期后维持该计划的计划。参与该项目的 PI 和导师致力于在 UNMC 内延续指导文化。此外，该中心的成立所产生的协作环境已经并将继续加强内布拉斯加州牙科和医学院内的研究基础设施。