Combined Peanut Oral Immunotherapy and Anti-IgE: Mechanistic Studies

花生口服免疫疗法与抗 IgE 联合治疗:机制研究

基本信息

  • 批准号:
    8320084
  • 负责人:
  • 金额:
    $ 18.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-08-15 至 2013-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Oral tolerance to foods normally develops during the first few years of life. An aberration of oral tolerance, food allergy, occurs in 6% of children and 3.5% of adults in the United States. Peanut allergy is one of the most common of the food allergies occurring in 1% of young children and is the leading cause of fatal food anaphylaxis. Only 20% of young children will develop oral tolerance to peanuts by age 5 years. We propose to utilize a combination of treatments, anti-IgE (omalizumab) and peanut oral immunotherapy (OIT) to investigate and possibly hasten the development of oral tolerance to peanuts. This application is based on our data from our work and others that allergen-specific OIT will desensitize and possibly tolerize peanut-allergic subjects. The long term goal and significance of this proposal is to better understand the development of oral tolerance to foods. Our approach will be to study the basophil/mast cell reactivity, antigen-specific T cell responses and mucosal and systemic humoral immune responses in these subjects on anti-IgE and peanut OIT. Our hypothesis is that by beginning treatment with anti-IgE and then starting peanut OIT we will clinically desensitize patients by altering basophil/mast cell reactivity and will cause eventual clinical tolerance to develop because of the activity of allergen-specific T regulatory cells. Previous studies of peanut OIT from our group of investigators show that during the first 6 - 9 months of OIT the subjects become desensitized to peanuts and will tolerate up to 15 peanuts without symptoms. For those subjects on treatment with OIT longer than 2 1/2 years, more than 50% are now clinically tolerant to peanuts. The clinical study this proposal is attached to is a prospective trial at Duke University with peanut-allergic subjects. We will enroll 10 patients. The study will consist of 4 phases: anti-IgE therapy before immunotherapy, a modified rush day(s), a build-up period of 4 months, and a daily home maintenance phase with a final dose of 8000mg peanut flour (~50% peanut protein). The anti-IgE will be started 4 months prior to the initial modified rush day(s) and continued for one month after they have reached the daily maintenance dose of peanut OIT (8 gms) (total anti-IgE time 10 months). Importantly, we will conduct the following mechanistic studies at the beginning of treatment with anti-IgE, prior to starting peanut OIT and then at various appropriate intervals thereafter to determine the individual and collective contribution of anti-IgE and peanut OIT to the immune changes. We want to establish an immunotherapeutic approach that would down-regulate food specific immune responses, lower the risk of allergic reactions to accidental exposure to foods in the millions of Americans who suffer from food allergy and develop an eventual treatment that will cause true clinical tolerance. This study will provide new insights into peanut-specific cellular and humoral immune responses and oral tolerance.
描述(由申请人提供):对食物的口服耐受性通常在生命的最初几年形成。在美国,6%的儿童和3.5%的成年人发生口服耐受性异常,即食物过敏。花生过敏是最常见的食物过敏之一,发生在1%的幼儿中,是致命的食物过敏反应的主要原因。只有20%的幼儿在5岁时会对花生产生口服耐受性。我们建议利用抗IgE(奥马珠单抗)和花生口服免疫疗法(OIT)的组合来研究并可能加速花生口服耐受性的发展。 该应用基于我们的工作数据和其他过敏原特异性OIT将脱敏并可能耐受花生过敏受试者的数据。本提案的长期目标和意义是更好地了解口服耐受性的发展。我们的方法将是研究嗜碱性粒细胞/肥大细胞的反应性,抗原特异性T细胞反应和粘膜和全身的体液免疫反应,在这些科目的抗IgE和花生OIT。我们的假设是,通过开始用抗IgE治疗,然后开始花生OIT,我们将通过改变嗜碱性粒细胞/肥大细胞的反应性使患者临床脱敏,并将由于过敏原特异性T调节细胞的活性而导致最终的临床耐受性发展。 我们的研究小组以前对花生OIT的研究表明,在OIT的前6 - 9个月,受试者对花生变得不敏感,并且可以耐受多达15个花生而没有症状。对于那些接受OIT治疗超过2 1/2年的受试者,超过50%的受试者现在对花生具有临床耐受性。 本提案所附的临床研究是在杜克大学对花生过敏受试者进行的前瞻性试验。我们将招募10名患者。该研究将包括4个阶段:免疫治疗前的抗IgE治疗、改良的高峰日、4个月的建立期和每日家庭维持期,最终剂量为8000 mg花生粉(约50%花生蛋白)。抗IgE将在初始改良高峰日前4个月开始,并在达到花生OIT每日维持剂量(8 g)后持续1个月(总抗IgE时间10个月)。重要的是,我们将在抗IgE治疗开始时、开始花生OIT之前以及之后的各种适当间隔进行以下机制研究,以确定抗IgE和花生OIT对免疫变化的个体和集体贡献。 我们希望建立一种免疫疗法,下调食物特异性免疫反应,降低数百万患有食物过敏的美国人意外暴露于食物的过敏反应风险,并开发出最终的治疗方法,从而导致真正的临床耐受性。这项研究将为花生特异性细胞和体液免疫反应以及口服耐受性提供新的见解。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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A. Wesley Burks其他文献

Intestinal Barrier Dysfunction Accompanies Peanut Allergy in CC027/GeniUnc Mice
  • DOI:
    10.1016/j.jaci.2020.12.616
  • 发表时间:
    2021-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Erin Steinbach;Johanna Smeekens;Layna Perini;Satyaki Roy;Ana Berglind;Michael Kulis;Martin Ferris;Terrence Furey;A. Wesley Burks;Shehzad Sheikh
  • 通讯作者:
    Shehzad Sheikh
Oral immunotherapy for food allergy: clinical and preclinical studies.
食物过敏的口服免疫疗法:临床和临床前研究。
Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE
花生过敏幼儿经皮免疫疗法的有效性和安全性:EPITOPE的开放标签扩展研究
  • DOI:
    10.1016/j.jaip.2025.02.004
  • 发表时间:
    2025-05-01
  • 期刊:
  • 影响因子:
    6.600
  • 作者:
    Matthew Greenhawt;Deborah Albright;Sara Anvari;Nicolette Arends;Peter D. Arkwright;Philippe Bégin;Katharina Blümchen;Terri Brown-Whitehorn;Heather Cassell;Edmond S. Chan;Christina E. Ciaccio;Antoine Deschildre;Amandine Divaret-Chauveau;Stacy Dorris;Morna Dorsey;George Du Toit;Thomas Eiwegger;Michel Erlewyn-Lajeunesse;David M. Fleischer;Lara S. Ford;A. Wesley Burks
  • 通讯作者:
    A. Wesley Burks
Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
  • DOI:
    10.1186/s13601-017-0142-2
  • 发表时间:
    2017-03-01
  • 期刊:
  • 影响因子:
    4.000
  • 作者:
    Guillaume Pouessel;Claire Claverie;Julien Labreuche;Jean-Marie Renaudin;Aimée Dorkenoo;Mireille Eb;Anne Moneret-Vautrin;Antoine Deschildre;Stephane Leteurtre;Linus Grabenhenrich;Margitta Worm;Sabine Dölle;Kathrin Scherer;Isidor Hutteger;Morten Christensen;Carsten Bindslev-Jensen;Charlotte Mortz;Esben Eller;Henrik Fomsgaard Kjaer;Leonor Carneiro-Leão;Jenny Badas;Alice Coimbra;Dikla Pivko Levy;Moshe Ben-Shoshan;Ayelet Rimon;Shira Benor;Nicolette J. T. Arends;Nikki Edelbroek;Hans de Groot;Joyce A. M. Emons;H. Kim A. Brand;Dirk Verhoeven;Leonieke N. van Veen;Nicolette W. de Jong;Geunwoong Noh;Eun Ha Jang;Mariona Pascal;Olga Dominguez;Mònica Piquer;Montserrat Alvaro;Rosa Jimenez-Feijoo;Jaime Lozano;Adriana Machinena;Maria del Mar Folqué;Maria Teresa Giner;Ana María Plaza;Paul Turner;Nandinee Patel;Marta Vazquez-Ortiz;Sarah Lindsley;Lucy Walker;Simon Rosenberg;Adriano Mari;Claudia Alessandri;Ivana Giangrieco;Lisa Tuppo;Chiara Rafaiani;Georg Mitterer;Michela Ciancamerla;Rosetta Ferrara;Maria Livia Bernardi;Danila Zennaro;Maurizio Tamburrini;Maria Antonetta Ciardiello;Christian Harwanegg;Antonio Fernandez;Regina Selb;Philippe Egenmann;Michelle Epstein;Karin Hoffmann-Sommergruber;Frits Koning;Martinus Lovik;E. N. Clare Mills;Javier Moreno;Henk van Loveren;Jean-Michel Wal;Susanne Diesner;Cornelia Bergmayr;Barbara Pfitzner;Vera Elisabeth Assmann;Philipp Starkl;David Endesfelder;Thomas Eiwegger;Zsolt Szepfalusi;Heinz Fehrenbach;Erika Jensen-Jarolim;Anton Hartmann;Isabella Pali-Schöll;Eva Untersmayr;Soren Wille;Peter Meyer;Caroline Klingebiel;Jonas Lidholm;Angelica Ehrenberg;Jonas Östling;Isabelle Cleach;Jean-Louis Mège;Joana Vitte;Roberta Aina;Pawel Dubiela;Sabine Pfeifer;Merima Bublin;Christian Radauer;Piotr Humeniuk;Stefan Kabasser;Riccardo Asero;Gador Bogas;Francisca Gomez;Paloma Campo;Maria Salas;Inmaculada Doña;Esther Barrionuevo;Maria Auxiliadora Guerrero;Cristobalina Mayorga;Ana Prieto;Domingo Barber;Maria Jose Torres;Annette Jamin;Andrea Wangorsch;Barbara Ballmer;Stefan Vieths;Stephan Scheurer;Danijela Apostolovic;Jelena Mihailovic;Maja Krstic;Maria Starkhammar;Tanja Cirkovic Velickovic;Carl Hamsten;Marianne van Hage;Francine C. van Erp;Edward F. Knol;Hannah M. Kansen;Bo Pontoppidan;Yolanda Meijer;Cornelis K. van der Ent;André C. Knulst;Rebekah Sayers;Helen Brown;Adnan Custovic;Angela Simpson;Claire Mills;Juliane Schulz;Jaap Akkerdaas;Muriel Totis;Annabelle Capt;Corinne Herouet-Guicheney;Ronald van Ree;Tushar Banerjee;Antima Banerjee;Mathilde Claude;Grégory Bouchaud;Roberta Lupi;Laure Castan;Olivier Tranquet;Sandra Denery-Papini;Marie Bodinier;Chantal Brossard;Rosella De Poi;Elisa Gritti;Emiliano De Dominicis;Bert Popping;Patrizia Polverino de Laureto;Kati Palosuo;Anna Kaarina Kukkonen;Anna Pelkonen;Mika Mäkelä;Nanju Alice Lee;Johanna Rost;Sridevi Muralidharan;Dianne Campbell;Sam Mehr;Catherine Nock;Joseph Baumert;Steve Taylor;Carla Mastrorilli;Salvatore Tripodi;Carlo Caffarelli;Serena Perna;Andrea Di Rienzo Businco;Ifigenia Sfika;Arianna Dondi;Annamaria Bianchi;Carlotta Povesi Dascola;Giampaolo Ricci;Francesca Cipriani;Nunzia Maiello;Michele Miraglia del Giudice;Tullio Frediani;Simone Frediani;Francesco Macrì;Chiara Pistoletti;Iride Dello Iacono;Maria Francesca Patria;Elena Varin;Diego Peroni;Pasquale Comberiati;Loredana Chini;Viviana Moschese;Sandra Lucarelli;Roberto Bernardini;Giuseppe Pingitore;Umberto Pelosi;Roberta Olcese;Matteo Moretti;Anastasia Cirisano;Diego Faggian;Alessandro Travaglini;Mario Plebani;Maria Carmen Verga;Mauro Calvani;Paolo Giordani;Paolo Maria Matricardi;Noe Ontiveros;Francisco Cabrera-Chavez;Julie Galand;Etienne Beaudouin;Florence Pineau;Shinobu Sakai;Kayoko Matsunaga;Reiko Teshima;Colette Larré;Sandra Denery;Sebastian Tschirner;Valérie Trendelenburg;Gabriele Schulz;Bodo Niggemann;Kirsten Beyer;Youcef Bouferkas;Younes Belabbas;Djamel Saidi;Omar Kheroua;Kamel Eddine El Mecherfi;Malika Guendouz;Abir Haddi;Hanane Kaddouri;Luis Amaral;Ana Pereira;Susana Rodrigues;Mareen Datema;Laurian Jongejan;Michael Clausen;Andre Knulst;Nikolaos Papadopoulos;Marek Kowalski;Frédéric de Blay;Aeilko Zwinderman;Karin Hoffman-Sommergruber;Barbara Ballmer-Weber;Montserrat Fernandez-Rivas;Shan Deng;Jia Yin;Charlotte Eisenmann;Maria Nassiri;Rabea Reinert;Johanna P. M. van der Valk;Roy Gerth van Wijk;Yvonne Vergouwe;Ewout W. Steyerberg;Marit Reitsma;Harry J. Wichers;Huub F. J. Savelkoul;Berber Vlieg-Boerstra;Anthony E. J. Dubois;Nicolette W. de Jong;Fabrícia Carolino;Ana Rodolfo;Josefina Cernadas;Dasha Roa-Medellín;Ana Rodriguez-Fernandez;Joaquín Navarro;Vicente Albendiz;María Luisa Baeza;Sonsoles Intente-Herrero;Andrea Mikkelsen;Kirsten Mehlig;Lauren Lissner;Linda Verrill;Stefano Luccioli;Jolanda van Bilsen;Frieke Kuper;André Wolterbeek;Tanja Rouhani Rankouhi;Lars Verschuren;Hilde Cnossen;Prescilla Jeurink;Johan Garssen;Léon Knippels;Jossie Garthoff;Geert Houben;Winfried Leeman;M. Eleonore Pettersson;Afke M. M. Schins;Gerard H. Koppelman;Boudewjin J. Kollen;Svitlana Zubchenko;Sarah Kuntz;Pablo Mérida;Montserrat Álvaro;Monica Piquer;Carmen Riggioni;Juan Heber Castellanos;Rosa Jimenez;Melanie Cap;Elodie Drumez;Stéphanie Lejeune;Caroline Thumerelle;Clémence Mordacq;Véronique Nève;Sonia Ricò;Margherita Varini;Rita Nocerino;Linda Cosenza;Antonio Amoroso;Margherita Di Costanzo;Carmen Di Scala;Giorgio Bedogni;Roberto Berni Canani;Paul J. Turner;Paloma Poza-Guedes;Ruperto González-Pérez;Inmaculada Sánchez-Machín;Victor Matheu-Delgado;Erik Wambre;Anne-Sofie Ballegaard;Charlotte Madsen;Juliane Gregersen;Katrine Lindholm Bøgh;Philippe Aubert;Michel Neunlist;Antoine Magnan;Daniel Lozano-Ojalvo;Alba Pablos-Tanarro;Leticia Pérez-Rodríguez;Elena Molina;Rosina López-Fandiño;Akila Rekima;Patricia Macchiaverni;Mathilde Turfkruyer;Sebastien Holvoet;Lénaïck Dupuis;Nour Baiz;Isabella Annesi-Maesano;Annick Mercenier;Sophie Nutten;Valérie Verhasselt;Ines Mrakovcic-Sutic;Srdan Banac;Ivana Sutic;Zdenka Baricev-Novakovic;Ingrid Sutic;Valentino Pavisic;Rosa Muñoz-Cano;Teodoríkez Jiménez-Rodríguez;Daniel Corbacho;Jordi Roca-Ferrer;Joan Bartra;Aleksandar Bulog;Vladimir Micovic;Lidia Markiewicz;Agata Szymkiewicz;Anna Szyc;Barbara Wróblewska;Bryan M. Harvey;Lucien F. Harthoorn;A. Wesley Burks;Georgios Rentzos;Anna-Lena Bramstång Björk;Ulf Bengtsson;Colin Barber;Chrystyna Kalicinsky;Christine Breynaert;Lieve Coorevits;Cornelia Jansen;Erna Van Hoeyveld;Kristin Verbeke;Anne-Marie Kochuyt;Rik Schrijvers;Diana Deleanu;Adriana Muntean;Maria Konstantakopoulou;Maria Pasioti;Anastasia Papadopoulou;Anna Iliopoulou;Nikolaos Mikos;Evangelia Kompoti;Eunice Dias de Castro;Borja Bartalomé;Kok Loong Ue;Elizabeth Griffiths;Stephen Till;Kate Grimshaw;Graham Roberts;Anna Selby;Indre Butiene;Jose Ignacio Larco;Ruta Dubakiene;Ana Fiandor;Alessandro Fiocchi;Nikos Papadopoulos;Sigurveig Sigurdardottir;Aline Sprikkelman;Anne-Fleur Schoemaker;Paraskevi Xepapadaki;Thomas Keil;Zizi Cojocariu;Beatriz Secades Barbado;Vasti Iancu;Esozia Arroabarren;Marta Goñi Esarte;Miren Arteaga;Mayra Coutinho Andrade;Denise Borges;Jorge Kalil;Pedro Giavina Bianchi;Rosana Camara Agondi;Rinkesh Kumar Gupta;Akanksha Sharma;Kriti Gupta;Mukul Das;Premendra Dwivedi;Rusudan Karseladze;Liana Jorjoliani;Lali Saginadze;Mariam Tskhakaia;Katia Basello;Gabriele Piuri;Attilio Francesco Speciani;Michela Carola Speciani;Carla Camerotto;Francesco Zinno;Olga Pakholchuk;Svitlana Nedelska;Stefano Pattini;Maria Teresa Costantino;Silvia Peveri;Danilo Villalta;Eleonora Savi;Andrea Costanzi;Vera A. Revyakina;Marina A. Kiseleva;Elena D. Kuvshinova;Inna A. Larkova;Anton A. Shekhetov;Diana Silva;André Moreira;José Plácido;Hanneke van der Kleij;Esther van Twuijver;Robbert Sutorius;Pieter-Jan de Kam;Jenny van Odijk;Helen Lindqvist;Elin Lustig;Amyra Ali Azamar Jácome;Karla Leversia Borjas Aguilar;Miguel García Domínguez;David Alejandro Mendoza Hernández;Cristiano Caruso;Cono Casale;Gian Lodovico Rapaccini;Antonino Romano;Italo De Vitis;Renata R. Cocco;Carolina Aranda;Marcia C. Mallozi;Jackeline F. Motta;Lilian Moraes;Antonio Pastorino;Nelson Rosario;Ekaterini Goudouris;Arnaldo Porto;Neusa F. Wandalsen;Emanuel Sarinho;Flavio Sano;Dirceu Solé;Constantinos Pitsios;Maria Petrodimopoulou;Ekaterini Papadopoulou;Maria Passioti;Meropi Kontogianni;Nino Adamia;Ekaterina Khaleva;Ana Prieto del Prado;George Du Toit;Edyta Krzych;Urszula Samolinska-Zawisza;Konrad Furmanczyk;Aneta Tomaszewska;Filip Raciborski;Agnieszka Lipiec;Piotr Samel-Kowalik;Artur Walkiewicz;Jacek Borowicz;Boleslaw Samolinski;Aimee Lou Nano;Marysia Recto;Maria Luisa Somoza;Natalia Blanca López;Diana Pérez Alzate;Francisco Javier Ruano;Maria Isabel Garcimartín;Elisa Haroun;Maria Vázquez de la Torre;Antonia Rojas;Montserrat López Onieva;Gabriela Canto;Alexandra Rodrigues;Andreia Forno;António Jorge Cabral;Rute Gonçalves;Ilya Vorozhko;Tatyana Sentsova;Olga Chernyak;Svetlana Denisova;Lidia Ilènko;Valery Muhortnich;Caroline Zimmermann;Alexander Rohrbach;Faisal R. Bakhsh;Kollen Boudewijn;Anne-Marie Oomkes-Pilon;Dorien Van Ginkle;Mira Šilar;Anja Jeverica;Tina Vesel;Tadej Avčin;Peter Korošec;Johanna van der Valk;Irene Berends;Nicolette Arends;Maurits van Maaren;Harry Wichers;Joyce Emons;Anthony Dubois;Nicolette de Jong;Oksana Matsyura;Lesya Besh;Chung-Hsiung Huang;Tong-Rong Jan;Gary Stiefel;Jean Tratt;Kerrie Kirk;Fabricia Carolino;Stefania Arasi;Lucia Caminiti;Giuseppe Crisafulli;Chiara Fiamingo;Jlenia Fresta;Giovanni Pajno;Ben Remington;Astrid Kruizinga;W. Marty Blom;Joost Westerhout;Sabina Bijlsma;Joe Baumert;Mark Blankestijn;Henny Otten;Rob Klemans;Anouska D. Michelsen-Huisman;Harmieke van Os-Medendorp;Astrid G. Kruizinga;Astrid Versluis;Gert van Duijn;H. Mary-Lene de Zeeuw-Brouwer;Jacqueline J. M. Castenmiller;Hub P. J. M. Noteborn;Geert F. Houben;Kristian Bravin;David Luyt;Bushra Javed;Phil Couch;Christopher Munro;Phil Padfield;Matt Sperrin;Aideen Byrne;Lizalet Oosthuizen;Carina Kelleher;Fiona Ward;Niamh Brosnan;Graham King;Eva Corbet;Josué Alejandro Huertas Guzmán;Montserrat Bosque García;Oscar Asensio;Laura Valdesoiro Navarrete;Helena Larramona;Xavier Domingo Miró;Katarzyna Pyrz;Moira Austin;Yanne Boloh;Philip Couch;Deirdre Galloway;Pilar Hernandez;Jonathan O’B. Hourihane;Fiona Kenna;Barbara Majkowska-Wojciechowska;Lynne Regent;Marina Themisb;Sabine Schnadt;Aida Semic-Jusufagic;Audrey Dunn Galvin;Tiina Kauppila;Mikael Kuitunen;Nikolaos A. Kitsioulis;Nikolaos Douladiris;Sofia Kostoudi;Ioanna Manolaraki;Dimitris Mitsias;Emmanouil Manousakis;Nikolaos G. Papadopoulos;Rebecca Knibb;Jennifer Hammond;Richard Cooke;Jaakko Yrjänä;Anna-Maija Hanni;Päivi Vähäsarja;Oona Mustonen;Teija Dunder;Petri Kulmala;Eva Lasa;Carmen D’Amelio;Sara Martínez;Alejandro Joral;Gabriel Gastaminza;Maria Jose Goikoetxea;David C. A. Candy;Marleen T. J. Van Ampting;Manon M. Oude Nijhuis;Assad M. Butt;Diego G. Peroni;Adam T. Fox;Jan Knol;Louise J. Michaelis;Ines Padua;Patricia Padrao;Pedro Moreira;Renata Barros;Hanan Sharif;Manzoor Ahmed;Nehad Gomaa;Joris Mens;Koen Smit;Frans Timmermans;Tomaž Poredoš;Anja Koren Jeverica;Marjeta Sedmak;Evgen Benedik;Meta Accetto;Mirjana Zupančič;Glauce Yonamine;Gustavo Soldateli;Bruna Aquilante;Antonio Carlos Pastorino;Cleonir Lui de Moraes Beck;Andrea Keiko Gushken;Mayra de Barros Dorna;Cristiane Nunes dos Santos;Ana Paula Moschione Castro;Abdulhadi Al-Qahtani;Rand Arnaout;Agha Rehan Khaliq;Rashid Amin;Farrukh Sheikh;Jorge Alvarez;Marta Anda;Miriam Palacios;Montserrat De Prada;Carmen Ponce;Bianca Balbino;Riccardo Sibilano;Thomas Marichal;Nicolas Gaudenzio;Hajime Karasuyama;Pierre Bruhns;Mindy Tsai;Laurent L. Reber;Stephen J. Galli;Ana Reis Ferreira;Josefina R. Cernadas;Aida del Campo García;Sara Pereiro Fernández;Nerea Sarmiento Carrera;Fernando Bandrés Sánchez-Cruz;José Ramón Fernández Lorenzo;Stephanie Claus;Claudia Pföhler;Franziska Ruëff;Regina Treudler;Mercedes Escarrer Jaume;Agustin Madroñero;Maria Teresa Guerra Perez;Juan Carlos Julia;Charlotte Hands Plovdiv;Lee Gethings;Jim Langridge;Karine Adel-Patient;Hervé Bernard;Ivona Barcievic-Jones;Raditsa Sokolova;Rumyana Yankova;Mariya Ivanovska;Marianna Murdjeva;Tatyana Popova;Svetlan Dermendzhiev;Martin Karjalainen;Ulrike Lehnigk;Duncan Brown;Julie C. Locklear;Julie Locklear;Ioana Maris;Jonathan Hourihane;Cristina Ornelas;Joana Caiado;Manuel Branco Ferreira;Manuel Pereira-Barbosa;Yolanda Puente;Juan Carlos Daza;Francisco Javier Monteseirin;Natalia Ukleja-Sokolowska;Ewa Gawronska-Ukleja;Magdalena Zbikowska-Gotz;Zbigniew Bartuzi;Lukasz Sokolowski;Aine Adams;Bernard Mahon;Karen English;Nelly Gourdon-Dubois;Laetitia Sellam;Bruno Pereira;Elodie Michaud;Khaled Messaoudi;Bertrand Evrard;Jean-Luc Fauquert;Francisca Palomares;Gador Gomez;Maria Jose Rodriguez;Luisa Galindo;Ana Molina;Lorella Paparo;Maurizio Mennini;Rosita Aitoro;Adam Wawrzeńczyk;Michał Przybyszewski;Anna Wawrzeńczyk;Hulya Ercan Sarıcoban;Meltem Ugras;Zerrin Yalvac;Bertine M. J. Flokstra-de Blok;J. L. van der Velde;Andrea Vereda;Clara Ippolito;Amaranta Traversa;Daniela Adriano;Daniela Manila Bianchi;Silvia Gallina;Lucia Decastelli;Melina Makatsori;Anne Miles;Sonja Posega Devetak;Iztok Devetak;Soraya Ainad Tabet;Jeanette Fisker Trandbohus;Pernille Winther;Hans-Jørgen Malling;Kirsten Skamstrup Hansen;Lene Heise Garvey;Chia-Chi Wang;Yin-Hua Cheng;Chun-Wei Tung;Mariola Dietrich;Ingo Marenholz;Birgit Kalb;Sarah Grosche;Katharina Blümchen;Rupert Schlags;Mareike Price;Sylke Rietz;Jorge Esparza-Gordillo;Susanne Lau;Young-Ae Lee;Ali Almontasheri;Mohammad Al Bahkali;Sahar Elshorbagi;Abdullah Alfhaid;Mashary Altamimi;Eman Madbouly;Hassan Al-Dhekri;Rand K. 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  • 通讯作者:
    Carla Jones
Pollen food syndrome: Update on the allergens
  • DOI:
    10.1007/s11882-008-0080-0
  • 发表时间:
    2008-09-01
  • 期刊:
  • 影响因子:
    4.600
  • 作者:
    Alison Hofmann;A. Wesley Burks
  • 通讯作者:
    A. Wesley Burks

A. Wesley Burks的其他文献

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{{ truncateString('A. Wesley Burks', 18)}}的其他基金

NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    9443585
  • 财政年份:
    2017
  • 资助金额:
    $ 18.5万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    9889023
  • 财政年份:
    2017
  • 资助金额:
    $ 18.5万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10631369
  • 财政年份:
    2017
  • 资助金额:
    $ 18.5万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10581628
  • 财政年份:
    2017
  • 资助金额:
    $ 18.5万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10363631
  • 财政年份:
    2017
  • 资助金额:
    $ 18.5万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10398330
  • 财政年份:
    2017
  • 资助金额:
    $ 18.5万
  • 项目类别:
Combined Peanut Oral Immunotherapy and Anti-IgE: Mechanistic Studies
花生口服免疫疗法与抗 IgE 联合治疗:机制研究
  • 批准号:
    8449783
  • 财政年份:
    2011
  • 资助金额:
    $ 18.5万
  • 项目类别:
Combined Peanut Oral Immunotherapy and Anti-IgE: Mechanistic Studies
花生口服免疫疗法与抗 IgE 联合治疗:机制研究
  • 批准号:
    8094570
  • 财政年份:
    2011
  • 资助金额:
    $ 18.5万
  • 项目类别:
Sublingual Immunotherapy for Peanut Allergy
花生过敏的舌下免疫疗法
  • 批准号:
    7614511
  • 财政年份:
    2008
  • 资助金额:
    $ 18.5万
  • 项目类别:
Sublingual Immunotherapy for Peanut Allergy
花生过敏的舌下免疫疗法
  • 批准号:
    9045572
  • 财政年份:
    2008
  • 资助金额:
    $ 18.5万
  • 项目类别:

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