Sublingual Immunotherapy for Peanut Allergy

花生过敏的舌下免疫疗法

基本信息

  • 批准号:
    7614511
  • 负责人:
  • 金额:
    $ 38.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-05-01 至 2013-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Oral tolerance to foods normally develops during the first few years of life. An aberration of oral tolerance, food allergy, occurs in 6% of children and 3.5% of adults in the United States. Peanut allergy is one of the most common of the food allergies occurring in 1% of young children. Interestingly, approximately only 20% of young children with peanut allergy will develop oral tolerance to peanuts by age five. We propose to utilize a form of treatment, sublingual immunotherapy (SLIT) to investigate and possibly hasten the development of oral tolerance to peanuts. This application is based on data from our work and others that allergen-specific SLIT will desensitize and possibly tolerize peanut-allergic subjects. There have not been well-designed previous studies of SLIT for food allergy that have been scientifically rigorous. Our hypothesis is that instituting peanut allergen SLIT early after development of food allergy will clinically desensitize patients by altering basophil/mast cell reactivity and will cause clinical tolerance to develop because of the activity of allergen- specific T regulatory cells. This proposal is based on our preliminary studies that have examined the effects of SLIT in older children with peanut allergy and of oral immunotherapy in peanut- and egg-allergic children. Our approach will be to enroll two cohorts of subjects who have peanut sensitivity (peanut specific IgE > 7 KU/L and significant initial symptoms); one group soon after their development (ages 1 to 5 years) and the second group who have not outgrown their peanut allergy (ages 6 to 11 years) and treat them with peanut SLIT in a prospective randomized, blinded SLIT protocol. We will study the basophil/mast cell reactivity, antigen-specific T cell responses and mucosal and systemic humoral immune responses in these subjects. We are combining the expertise of scientific investigators from the fields of allergy, immunology and pathology and the resources of our NIH-funded GCRC for our studies. Our specific aims are: (1) Determine if allergen-specific SLIT will cause clinical desensitization and tolerance to develop in peanut allergic young children, (2) Determine if the development of the desensitized state to peanut is associated with the down-regulation of mast cells and basophils, (3) Determine if the development of clinical tolerance to peanuts is associated with an increase in the T regulatory phenotype of antigen-activated peripheral CD4+ T cells and (4) Determine the effect of peanut-specific mucosal and systemic humoral immune responses in SLIT on desensitization and oral tolerance. Completion of the studies will provide new information regarding the cellular and molecular mechanisms of action of oral tolerance and allergen-specific SLIT and provide the foundation for the development of novel treatments for food allergy. PUBLIC HEALTH RELEVANCE - PROJECT NARRATIVE: The project is designed to develop a treatment for food allergy. Food allergy effect 6% - 8% of young children and 4% of adults and there are no current preventive treatment available. The development of a treatment and understanding the mechanism of how it works is important for the future treatment of patients with food allergy.
描述(由申请人提供):口腔对食物的耐受性通常在生命的最初几年发展起来。在美国,6%的儿童和3.5%的成年人会出现一种口服耐受性异常,即食物过敏。花生过敏是最常见的食物过敏之一,发生在1%的幼儿身上。有趣的是,大约只有20%对花生过敏的幼儿在5岁前会对花生产生口服耐受性。我们建议利用一种治疗形式,舌下免疫疗法(SIT)来研究并可能加速口服花生耐受性的发展。这项应用是基于我们的工作和其他人的数据,过敏原特异性SILT将使花生过敏对象脱敏,并可能耐受。在此之前,还没有经过精心设计的关于食物过敏的科学严谨的研究。我们的假设是,在食物过敏发生后早期建立花生变应原SILT将通过改变嗜碱性细胞/肥大细胞的反应性而在临床上使患者脱敏,并将由于过敏原特异性T调节细胞的活性而导致临床耐受性的形成。这一建议是基于我们的初步研究,这些研究检查了Sit对患有花生过敏的大龄儿童的影响,以及口服免疫疗法对花生和鸡蛋过敏儿童的影响。我们的方法是招募两组对花生敏感的受试者(花生特异性IgE和GT;7KU/L,有明显的初始症状);一组在发育后不久(1-5岁),第二组还没有摆脱花生过敏(6-11岁),并采用前瞻性随机、盲法狭缝方案对他们进行花生狭缝治疗。我们将研究这些受试者的嗜碱性粒细胞/肥大细胞反应性、抗原特异性T细胞反应以及粘膜和系统体液免疫反应。我们正在结合过敏、免疫学和病理学领域的科学研究人员的专业知识,以及我们由NIH资助的GCRC的资源来进行我们的研究。我们的具体目标是:(1)确定过敏原特异性Sit是否会导致花生过敏幼儿的临床脱敏和耐受,(2)确定对花生的脱敏状态的发展是否与肥大细胞和嗜碱性粒细胞下调有关,(3)确定临床对花生的耐受的发展是否与抗原激活的外周CD4+T细胞T调节表型增加有关,以及(4)确定Sit中花生特异的粘膜和系统体液免疫反应对脱敏和口服耐受的影响。这些研究的完成将为口服耐受和变应原特异性缝隙的细胞和分子作用机制提供新的信息,并为开发新的食物过敏治疗方法提供基础。 公共卫生相关性-项目描述:该项目旨在开发一种食物过敏的治疗方法。6%-8%的幼儿和4%的成年人会对食物过敏,目前还没有预防性的治疗方法。开发一种治疗方法并了解其作用机制对于未来食物过敏患者的治疗非常重要。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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A. Wesley Burks其他文献

Intestinal Barrier Dysfunction Accompanies Peanut Allergy in CC027/GeniUnc Mice
  • DOI:
    10.1016/j.jaci.2020.12.616
  • 发表时间:
    2021-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Erin Steinbach;Johanna Smeekens;Layna Perini;Satyaki Roy;Ana Berglind;Michael Kulis;Martin Ferris;Terrence Furey;A. Wesley Burks;Shehzad Sheikh
  • 通讯作者:
    Shehzad Sheikh
Oral immunotherapy for food allergy: clinical and preclinical studies.
食物过敏的口服免疫疗法:临床和临床前研究。
Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE
花生过敏幼儿经皮免疫疗法的有效性和安全性:EPITOPE的开放标签扩展研究
  • DOI:
    10.1016/j.jaip.2025.02.004
  • 发表时间:
    2025-05-01
  • 期刊:
  • 影响因子:
    6.600
  • 作者:
    Matthew Greenhawt;Deborah Albright;Sara Anvari;Nicolette Arends;Peter D. Arkwright;Philippe Bégin;Katharina Blümchen;Terri Brown-Whitehorn;Heather Cassell;Edmond S. Chan;Christina E. Ciaccio;Antoine Deschildre;Amandine Divaret-Chauveau;Stacy Dorris;Morna Dorsey;George Du Toit;Thomas Eiwegger;Michel Erlewyn-Lajeunesse;David M. Fleischer;Lara S. Ford;A. Wesley Burks
  • 通讯作者:
    A. Wesley Burks
Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
  • DOI:
    10.1186/s13601-017-0142-2
  • 发表时间:
    2017-03-01
  • 期刊:
  • 影响因子:
    4.000
  • 作者:
    Guillaume Pouessel;Claire Claverie;Julien Labreuche;Jean-Marie Renaudin;Aimée Dorkenoo;Mireille Eb;Anne Moneret-Vautrin;Antoine Deschildre;Stephane Leteurtre;Linus Grabenhenrich;Margitta Worm;Sabine Dölle;Kathrin Scherer;Isidor Hutteger;Morten Christensen;Carsten Bindslev-Jensen;Charlotte Mortz;Esben Eller;Henrik Fomsgaard Kjaer;Leonor Carneiro-Leão;Jenny Badas;Alice Coimbra;Dikla Pivko Levy;Moshe Ben-Shoshan;Ayelet Rimon;Shira Benor;Nicolette J. T. Arends;Nikki Edelbroek;Hans de Groot;Joyce A. M. Emons;H. Kim A. Brand;Dirk Verhoeven;Leonieke N. van Veen;Nicolette W. de Jong;Geunwoong Noh;Eun Ha Jang;Mariona Pascal;Olga Dominguez;Mònica Piquer;Montserrat Alvaro;Rosa Jimenez-Feijoo;Jaime Lozano;Adriana Machinena;Maria del Mar Folqué;Maria Teresa Giner;Ana María Plaza;Paul Turner;Nandinee Patel;Marta Vazquez-Ortiz;Sarah Lindsley;Lucy Walker;Simon Rosenberg;Adriano Mari;Claudia Alessandri;Ivana Giangrieco;Lisa Tuppo;Chiara Rafaiani;Georg Mitterer;Michela Ciancamerla;Rosetta Ferrara;Maria Livia Bernardi;Danila Zennaro;Maurizio Tamburrini;Maria Antonetta Ciardiello;Christian Harwanegg;Antonio Fernandez;Regina Selb;Philippe Egenmann;Michelle Epstein;Karin Hoffmann-Sommergruber;Frits Koning;Martinus Lovik;E. N. Clare Mills;Javier Moreno;Henk van Loveren;Jean-Michel Wal;Susanne Diesner;Cornelia Bergmayr;Barbara Pfitzner;Vera Elisabeth Assmann;Philipp Starkl;David Endesfelder;Thomas Eiwegger;Zsolt Szepfalusi;Heinz Fehrenbach;Erika Jensen-Jarolim;Anton Hartmann;Isabella Pali-Schöll;Eva Untersmayr;Soren Wille;Peter Meyer;Caroline Klingebiel;Jonas Lidholm;Angelica Ehrenberg;Jonas Östling;Isabelle Cleach;Jean-Louis Mège;Joana Vitte;Roberta Aina;Pawel Dubiela;Sabine Pfeifer;Merima Bublin;Christian Radauer;Piotr Humeniuk;Stefan Kabasser;Riccardo Asero;Gador Bogas;Francisca Gomez;Paloma Campo;Maria Salas;Inmaculada Doña;Esther Barrionuevo;Maria Auxiliadora Guerrero;Cristobalina Mayorga;Ana Prieto;Domingo Barber;Maria Jose Torres;Annette Jamin;Andrea Wangorsch;Barbara Ballmer;Stefan Vieths;Stephan Scheurer;Danijela Apostolovic;Jelena Mihailovic;Maja Krstic;Maria Starkhammar;Tanja Cirkovic Velickovic;Carl Hamsten;Marianne van Hage;Francine C. van Erp;Edward F. Knol;Hannah M. Kansen;Bo Pontoppidan;Yolanda Meijer;Cornelis K. van der Ent;André C. Knulst;Rebekah Sayers;Helen Brown;Adnan Custovic;Angela Simpson;Claire Mills;Juliane Schulz;Jaap Akkerdaas;Muriel Totis;Annabelle Capt;Corinne Herouet-Guicheney;Ronald van Ree;Tushar Banerjee;Antima Banerjee;Mathilde Claude;Grégory Bouchaud;Roberta Lupi;Laure Castan;Olivier Tranquet;Sandra Denery-Papini;Marie Bodinier;Chantal Brossard;Rosella De Poi;Elisa Gritti;Emiliano De Dominicis;Bert Popping;Patrizia Polverino de Laureto;Kati Palosuo;Anna Kaarina Kukkonen;Anna Pelkonen;Mika Mäkelä;Nanju Alice Lee;Johanna Rost;Sridevi Muralidharan;Dianne Campbell;Sam Mehr;Catherine Nock;Joseph Baumert;Steve Taylor;Carla Mastrorilli;Salvatore Tripodi;Carlo Caffarelli;Serena Perna;Andrea Di Rienzo Businco;Ifigenia Sfika;Arianna Dondi;Annamaria Bianchi;Carlotta Povesi Dascola;Giampaolo Ricci;Francesca Cipriani;Nunzia Maiello;Michele Miraglia del Giudice;Tullio Frediani;Simone Frediani;Francesco Macrì;Chiara Pistoletti;Iride Dello Iacono;Maria Francesca Patria;Elena Varin;Diego Peroni;Pasquale Comberiati;Loredana Chini;Viviana Moschese;Sandra Lucarelli;Roberto Bernardini;Giuseppe Pingitore;Umberto Pelosi;Roberta Olcese;Matteo Moretti;Anastasia Cirisano;Diego Faggian;Alessandro Travaglini;Mario Plebani;Maria Carmen Verga;Mauro Calvani;Paolo Giordani;Paolo Maria Matricardi;Noe Ontiveros;Francisco Cabrera-Chavez;Julie Galand;Etienne Beaudouin;Florence Pineau;Shinobu Sakai;Kayoko Matsunaga;Reiko Teshima;Colette Larré;Sandra Denery;Sebastian Tschirner;Valérie Trendelenburg;Gabriele Schulz;Bodo Niggemann;Kirsten Beyer;Youcef Bouferkas;Younes Belabbas;Djamel Saidi;Omar Kheroua;Kamel Eddine El Mecherfi;Malika Guendouz;Abir Haddi;Hanane Kaddouri;Luis Amaral;Ana Pereira;Susana Rodrigues;Mareen Datema;Laurian Jongejan;Michael Clausen;Andre Knulst;Nikolaos Papadopoulos;Marek Kowalski;Frédéric de Blay;Aeilko Zwinderman;Karin Hoffman-Sommergruber;Barbara Ballmer-Weber;Montserrat Fernandez-Rivas;Shan Deng;Jia Yin;Charlotte Eisenmann;Maria Nassiri;Rabea Reinert;Johanna P. M. van der Valk;Roy Gerth van Wijk;Yvonne Vergouwe;Ewout W. Steyerberg;Marit Reitsma;Harry J. Wichers;Huub F. J. Savelkoul;Berber Vlieg-Boerstra;Anthony E. J. Dubois;Nicolette W. de Jong;Fabrícia Carolino;Ana Rodolfo;Josefina Cernadas;Dasha Roa-Medellín;Ana Rodriguez-Fernandez;Joaquín Navarro;Vicente Albendiz;María Luisa Baeza;Sonsoles Intente-Herrero;Andrea Mikkelsen;Kirsten Mehlig;Lauren Lissner;Linda Verrill;Stefano Luccioli;Jolanda van Bilsen;Frieke Kuper;André Wolterbeek;Tanja Rouhani Rankouhi;Lars Verschuren;Hilde Cnossen;Prescilla Jeurink;Johan Garssen;Léon Knippels;Jossie Garthoff;Geert Houben;Winfried Leeman;M. Eleonore Pettersson;Afke M. M. Schins;Gerard H. Koppelman;Boudewjin J. Kollen;Svitlana Zubchenko;Sarah Kuntz;Pablo Mérida;Montserrat Álvaro;Monica Piquer;Carmen Riggioni;Juan Heber Castellanos;Rosa Jimenez;Melanie Cap;Elodie Drumez;Stéphanie Lejeune;Caroline Thumerelle;Clémence Mordacq;Véronique Nève;Sonia Ricò;Margherita Varini;Rita Nocerino;Linda Cosenza;Antonio Amoroso;Margherita Di Costanzo;Carmen Di Scala;Giorgio Bedogni;Roberto Berni Canani;Paul J. Turner;Paloma Poza-Guedes;Ruperto González-Pérez;Inmaculada Sánchez-Machín;Victor Matheu-Delgado;Erik Wambre;Anne-Sofie Ballegaard;Charlotte Madsen;Juliane Gregersen;Katrine Lindholm Bøgh;Philippe Aubert;Michel Neunlist;Antoine Magnan;Daniel Lozano-Ojalvo;Alba Pablos-Tanarro;Leticia Pérez-Rodríguez;Elena Molina;Rosina López-Fandiño;Akila Rekima;Patricia Macchiaverni;Mathilde Turfkruyer;Sebastien Holvoet;Lénaïck Dupuis;Nour Baiz;Isabella Annesi-Maesano;Annick Mercenier;Sophie Nutten;Valérie Verhasselt;Ines Mrakovcic-Sutic;Srdan Banac;Ivana Sutic;Zdenka Baricev-Novakovic;Ingrid Sutic;Valentino Pavisic;Rosa Muñoz-Cano;Teodoríkez Jiménez-Rodríguez;Daniel Corbacho;Jordi Roca-Ferrer;Joan Bartra;Aleksandar Bulog;Vladimir Micovic;Lidia Markiewicz;Agata Szymkiewicz;Anna Szyc;Barbara Wróblewska;Bryan M. Harvey;Lucien F. Harthoorn;A. Wesley Burks;Georgios Rentzos;Anna-Lena Bramstång Björk;Ulf Bengtsson;Colin Barber;Chrystyna Kalicinsky;Christine Breynaert;Lieve Coorevits;Cornelia Jansen;Erna Van Hoeyveld;Kristin Verbeke;Anne-Marie Kochuyt;Rik Schrijvers;Diana Deleanu;Adriana Muntean;Maria Konstantakopoulou;Maria Pasioti;Anastasia Papadopoulou;Anna Iliopoulou;Nikolaos Mikos;Evangelia Kompoti;Eunice Dias de Castro;Borja Bartalomé;Kok Loong Ue;Elizabeth Griffiths;Stephen Till;Kate Grimshaw;Graham Roberts;Anna Selby;Indre Butiene;Jose Ignacio Larco;Ruta Dubakiene;Ana Fiandor;Alessandro Fiocchi;Nikos Papadopoulos;Sigurveig Sigurdardottir;Aline Sprikkelman;Anne-Fleur Schoemaker;Paraskevi Xepapadaki;Thomas Keil;Zizi Cojocariu;Beatriz Secades Barbado;Vasti Iancu;Esozia Arroabarren;Marta Goñi Esarte;Miren Arteaga;Mayra Coutinho Andrade;Denise Borges;Jorge Kalil;Pedro Giavina Bianchi;Rosana Camara Agondi;Rinkesh Kumar Gupta;Akanksha Sharma;Kriti Gupta;Mukul Das;Premendra Dwivedi;Rusudan Karseladze;Liana Jorjoliani;Lali Saginadze;Mariam Tskhakaia;Katia Basello;Gabriele Piuri;Attilio Francesco Speciani;Michela Carola Speciani;Carla Camerotto;Francesco Zinno;Olga Pakholchuk;Svitlana Nedelska;Stefano Pattini;Maria Teresa Costantino;Silvia Peveri;Danilo Villalta;Eleonora Savi;Andrea Costanzi;Vera A. Revyakina;Marina A. Kiseleva;Elena D. Kuvshinova;Inna A. Larkova;Anton A. Shekhetov;Diana Silva;André Moreira;José Plácido;Hanneke van der Kleij;Esther van Twuijver;Robbert Sutorius;Pieter-Jan de Kam;Jenny van Odijk;Helen Lindqvist;Elin Lustig;Amyra Ali Azamar Jácome;Karla Leversia Borjas Aguilar;Miguel García Domínguez;David Alejandro Mendoza Hernández;Cristiano Caruso;Cono Casale;Gian Lodovico Rapaccini;Antonino Romano;Italo De Vitis;Renata R. Cocco;Carolina Aranda;Marcia C. Mallozi;Jackeline F. Motta;Lilian Moraes;Antonio Pastorino;Nelson Rosario;Ekaterini Goudouris;Arnaldo Porto;Neusa F. Wandalsen;Emanuel Sarinho;Flavio Sano;Dirceu Solé;Constantinos Pitsios;Maria Petrodimopoulou;Ekaterini Papadopoulou;Maria Passioti;Meropi Kontogianni;Nino Adamia;Ekaterina Khaleva;Ana Prieto del Prado;George Du Toit;Edyta Krzych;Urszula Samolinska-Zawisza;Konrad Furmanczyk;Aneta Tomaszewska;Filip Raciborski;Agnieszka Lipiec;Piotr Samel-Kowalik;Artur Walkiewicz;Jacek Borowicz;Boleslaw Samolinski;Aimee Lou Nano;Marysia Recto;Maria Luisa Somoza;Natalia Blanca López;Diana Pérez Alzate;Francisco Javier Ruano;Maria Isabel Garcimartín;Elisa Haroun;Maria Vázquez de la Torre;Antonia Rojas;Montserrat López Onieva;Gabriela Canto;Alexandra Rodrigues;Andreia Forno;António Jorge Cabral;Rute Gonçalves;Ilya Vorozhko;Tatyana Sentsova;Olga Chernyak;Svetlana Denisova;Lidia Ilènko;Valery Muhortnich;Caroline Zimmermann;Alexander Rohrbach;Faisal R. Bakhsh;Kollen Boudewijn;Anne-Marie Oomkes-Pilon;Dorien Van Ginkle;Mira Šilar;Anja Jeverica;Tina Vesel;Tadej Avčin;Peter Korošec;Johanna van der Valk;Irene Berends;Nicolette Arends;Maurits van Maaren;Harry Wichers;Joyce Emons;Anthony Dubois;Nicolette de Jong;Oksana Matsyura;Lesya Besh;Chung-Hsiung Huang;Tong-Rong Jan;Gary Stiefel;Jean Tratt;Kerrie Kirk;Fabricia Carolino;Stefania Arasi;Lucia Caminiti;Giuseppe Crisafulli;Chiara Fiamingo;Jlenia Fresta;Giovanni Pajno;Ben Remington;Astrid Kruizinga;W. Marty Blom;Joost Westerhout;Sabina Bijlsma;Joe Baumert;Mark Blankestijn;Henny Otten;Rob Klemans;Anouska D. Michelsen-Huisman;Harmieke van Os-Medendorp;Astrid G. Kruizinga;Astrid Versluis;Gert van Duijn;H. Mary-Lene de Zeeuw-Brouwer;Jacqueline J. M. Castenmiller;Hub P. J. M. Noteborn;Geert F. Houben;Kristian Bravin;David Luyt;Bushra Javed;Phil Couch;Christopher Munro;Phil Padfield;Matt Sperrin;Aideen Byrne;Lizalet Oosthuizen;Carina Kelleher;Fiona Ward;Niamh Brosnan;Graham King;Eva Corbet;Josué Alejandro Huertas Guzmán;Montserrat Bosque García;Oscar Asensio;Laura Valdesoiro Navarrete;Helena Larramona;Xavier Domingo Miró;Katarzyna Pyrz;Moira Austin;Yanne Boloh;Philip Couch;Deirdre Galloway;Pilar Hernandez;Jonathan O’B. Hourihane;Fiona Kenna;Barbara Majkowska-Wojciechowska;Lynne Regent;Marina Themisb;Sabine Schnadt;Aida Semic-Jusufagic;Audrey Dunn Galvin;Tiina Kauppila;Mikael Kuitunen;Nikolaos A. Kitsioulis;Nikolaos Douladiris;Sofia Kostoudi;Ioanna Manolaraki;Dimitris Mitsias;Emmanouil Manousakis;Nikolaos G. Papadopoulos;Rebecca Knibb;Jennifer Hammond;Richard Cooke;Jaakko Yrjänä;Anna-Maija Hanni;Päivi Vähäsarja;Oona Mustonen;Teija Dunder;Petri Kulmala;Eva Lasa;Carmen D’Amelio;Sara Martínez;Alejandro Joral;Gabriel Gastaminza;Maria Jose Goikoetxea;David C. A. Candy;Marleen T. J. Van Ampting;Manon M. Oude Nijhuis;Assad M. Butt;Diego G. Peroni;Adam T. Fox;Jan Knol;Louise J. Michaelis;Ines Padua;Patricia Padrao;Pedro Moreira;Renata Barros;Hanan Sharif;Manzoor Ahmed;Nehad Gomaa;Joris Mens;Koen Smit;Frans Timmermans;Tomaž Poredoš;Anja Koren Jeverica;Marjeta Sedmak;Evgen Benedik;Meta Accetto;Mirjana Zupančič;Glauce Yonamine;Gustavo Soldateli;Bruna Aquilante;Antonio Carlos Pastorino;Cleonir Lui de Moraes Beck;Andrea Keiko Gushken;Mayra de Barros Dorna;Cristiane Nunes dos Santos;Ana Paula Moschione Castro;Abdulhadi Al-Qahtani;Rand Arnaout;Agha Rehan Khaliq;Rashid Amin;Farrukh Sheikh;Jorge Alvarez;Marta Anda;Miriam Palacios;Montserrat De Prada;Carmen Ponce;Bianca Balbino;Riccardo Sibilano;Thomas Marichal;Nicolas Gaudenzio;Hajime Karasuyama;Pierre Bruhns;Mindy Tsai;Laurent L. Reber;Stephen J. Galli;Ana Reis Ferreira;Josefina R. Cernadas;Aida del Campo García;Sara Pereiro Fernández;Nerea Sarmiento Carrera;Fernando Bandrés Sánchez-Cruz;José Ramón Fernández Lorenzo;Stephanie Claus;Claudia Pföhler;Franziska Ruëff;Regina Treudler;Mercedes Escarrer Jaume;Agustin Madroñero;Maria Teresa Guerra Perez;Juan Carlos Julia;Charlotte Hands Plovdiv;Lee Gethings;Jim Langridge;Karine Adel-Patient;Hervé Bernard;Ivona Barcievic-Jones;Raditsa Sokolova;Rumyana Yankova;Mariya Ivanovska;Marianna Murdjeva;Tatyana Popova;Svetlan Dermendzhiev;Martin Karjalainen;Ulrike Lehnigk;Duncan Brown;Julie C. 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L. van der Velde;Andrea Vereda;Clara Ippolito;Amaranta Traversa;Daniela Adriano;Daniela Manila Bianchi;Silvia Gallina;Lucia Decastelli;Melina Makatsori;Anne Miles;Sonja Posega Devetak;Iztok Devetak;Soraya Ainad Tabet;Jeanette Fisker Trandbohus;Pernille Winther;Hans-Jørgen Malling;Kirsten Skamstrup Hansen;Lene Heise Garvey;Chia-Chi Wang;Yin-Hua Cheng;Chun-Wei Tung;Mariola Dietrich;Ingo Marenholz;Birgit Kalb;Sarah Grosche;Katharina Blümchen;Rupert Schlags;Mareike Price;Sylke Rietz;Jorge Esparza-Gordillo;Susanne Lau;Young-Ae Lee;Ali Almontasheri;Mohammad Al Bahkali;Sahar Elshorbagi;Abdullah Alfhaid;Mashary Altamimi;Eman Madbouly;Hassan Al-Dhekri;Rand K. 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Aranda;Leire Dopazo;Rebeca Lopez;Raquel Perez;Laura Santos-Diez;Agurtzane Bilbao;Juan Miguel Garcia;Ignacio García Núñez;María Ángeles Algaba Mármol;María José Barasona Villarejo;José Antonio Bácter Martos;Marina Suárez Vergara;José María Ignacio García;Agata Michalska;Grzegorz Sergiejko;Robert Zacniewski;Ileana-Maria Ghiordanescu;Cristina Deaconu;Mihaela Popescu;Roxana Silvia Bumbacea;Alkerta Ibranji;Elida Nikolla;Gjustina Loloci;Nanna Juel-Berg;Lau Fabricius Larsen;Lars Kjaergaard Poulsen;João Marcelino;Ricardo Prata;Ana Célia Costa;Fátima Duarte;Marta Neto;Jennifer Santos;Luís Câmara Pestana;Daniel Sampaio;Paola Minale;Paola Dignetti;Donatella Bignardi;Irena Nedelea;Florin-Dan Popescu;Mariana Vieru;Florin-Adrian Secureanu;Carmen Saviana Ganea;Miguel Vieira;José Pedro Moreira Silva;Timothy Watts;Sophia Watts;Marta Lomikovska;Marina Peredelskaya;Natalia Nenasheva;Ivana Filipovic;Zorica Zivkovic;Djordje Filipovic;Jennette Higgs;Amena Warner;Carla Jones
  • 通讯作者:
    Carla Jones
Pollen food syndrome: Update on the allergens
  • DOI:
    10.1007/s11882-008-0080-0
  • 发表时间:
    2008-09-01
  • 期刊:
  • 影响因子:
    4.600
  • 作者:
    Alison Hofmann;A. Wesley Burks
  • 通讯作者:
    A. Wesley Burks

A. Wesley Burks的其他文献

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{{ truncateString('A. Wesley Burks', 18)}}的其他基金

NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    9443585
  • 财政年份:
    2017
  • 资助金额:
    $ 38.66万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    9889023
  • 财政年份:
    2017
  • 资助金额:
    $ 38.66万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10581628
  • 财政年份:
    2017
  • 资助金额:
    $ 38.66万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10631369
  • 财政年份:
    2017
  • 资助金额:
    $ 38.66万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10363631
  • 财政年份:
    2017
  • 资助金额:
    $ 38.66万
  • 项目类别:
NEW HORIZONS IN THE PREVENTION AND TREATMENT OF FOOD ALLERGY
预防和治疗食物过敏的新视野
  • 批准号:
    10398330
  • 财政年份:
    2017
  • 资助金额:
    $ 38.66万
  • 项目类别:
Combined Peanut Oral Immunotherapy and Anti-IgE: Mechanistic Studies
花生口服免疫疗法与抗 IgE 联合治疗:机制研究
  • 批准号:
    8449783
  • 财政年份:
    2011
  • 资助金额:
    $ 38.66万
  • 项目类别:
Combined Peanut Oral Immunotherapy and Anti-IgE: Mechanistic Studies
花生口服免疫疗法与抗 IgE 联合治疗:机制研究
  • 批准号:
    8094570
  • 财政年份:
    2011
  • 资助金额:
    $ 38.66万
  • 项目类别:
Combined Peanut Oral Immunotherapy and Anti-IgE: Mechanistic Studies
花生口服免疫疗法与抗 IgE 联合治疗:机制研究
  • 批准号:
    8320084
  • 财政年份:
    2011
  • 资助金额:
    $ 38.66万
  • 项目类别:
Sublingual Immunotherapy for Peanut Allergy
花生过敏的舌下免疫疗法
  • 批准号:
    7807204
  • 财政年份:
    2008
  • 资助金额:
    $ 38.66万
  • 项目类别:

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The role of dietary and blood proteins in the prevention and development of major age-related diseases
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