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A compact dose delivery system for proton radiation therapy

用于质子放射治疗的紧凑型剂量输送系统

基本信息

批准号：
8206805
负责人：
John M Cameron
金额：
$ 30.22万
依托单位：
PROCURE TREATMENT CENTERS, INC.
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-01 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8206805
关键词：
Academic Medical Centers Adverse effects Asia Cancer Patient Capital Clinical Computer software Contracts Cyclotrons Development Dimensions Dose Equipment Europe Evaluation FDA approved General Hospitals Goals High temperature of physical object Housing Indiana Light Magnetism Mainstreaming Marketing Massachusetts Mechanics Medical Research Medicare Motion Optics Patients Phase Price Process Protocols documentation Proton Radiation Protons Radiation Radiation therapy Ramp Research Research Design Robotics Scanning Site Small Business Innovation Research Grant Support System System Techniques Technology Testing Tissues Universities Validation Weight Work X-Ray Therapy base cancer therapy clinical application common treatment cost design dosimetry engineering design innovation interest new technology novel operation programs proton beam prototype public health relevance research study success transmission process treatment center treatment planning treatment site tumor

项目摘要

DESCRIPTION (provided by applicant): In comparison to standard x-ray therapy, proton therapy allows an increased dose of radiation to a tumor and by reducing the amount of radiation to healthy tissue. As a result, it provides the best possible option for using radiation to control and eliminate tumors with the least short and long term toxic side effects. Currently less than 1% of all radiation therapy patients receive proton therapy while the number of patients that would benefit substantially from their use with current protocols is estimated to be over 30%. The major barriers to greater utilization of proton therapy are the size and cost of the facilities. The layout of the current proton therapy treatment centers is dominated by the size of the iso-centric gantries that rotate the proton beam dose delivery system around the patient. ProCure's focus for this project is to invent a new gantry concept using modern robotics and high temperature superconducting magnets that will greatly reduce the gantry size and mass, the power needed to operate it and consequently the contribution of these gantries to the facility cost. ProCure proposes to research new technology that would reduce the gantry mass by an order of magnitude and cost by a factor of three. Phase I research will allow ProCure to determine the optimal design and components needed for a compact and low cost gantry based on novel beam scanning concepts and the use of high temperature superconducting magnet technology for use in Intensity Modulated Proton Therapy. In the first 12 months of Phase II, ProCure will work on constructing prototype magnets for the selected gantry concept, build key temporary magnet supports and nozzle components and in the next six months of Phase II, ProCure will carry out experiments using a full scale system in the Proton Dosimetry Test Facility recently commissioned at the Indiana University Cyclotron Facility. In Phase III, ProCure will complete the tests of the magnetic and nozzle operation at IUCF and make initial submission to the FDA. ProCure will construct a first prototype of the full rotating mechanical support system for the gantry and install the full system for mechanical system tests. In parallel, ProCure will start the acquisition process for the first systems that will be installed. Finally, FDA complete system testing for full FDA 510k approval will be performed. PUBLIC HEALTH RELEVANCE: Proton therapy provides the best possible option for using radiation to control and eliminate tumors with the least short and long term toxic side effects; however, only less than 1% of all radiation therapy patients receive proton therapy. The major barriers to greater utilization of proton therapy are the size and cost of the facilities. ProCure's new proton beam delivery concept will greatly reduce the size and mass of the system and the power needed to operate it, and consequently, help to bring this highly effective form of cancer treatment to the mainstream of radiation therapy.

描述（由申请人提供）：与标准 X 射线疗法相比，质子疗法允许增加对肿瘤的辐射剂量，并减少对健康组织的辐射量。因此，它为使用放射控制和消除肿瘤提供了最佳选择，且短期和长期毒副作用最小。目前，在所有放射治疗患者中，只有不到 1% 接受质子治疗，而从当前方案的使用中受益的患者数量估计超过 30%。进一步利用质子治疗的主要障碍是设施的规模和成本。当前质子治疗中心的布局主要取决于围绕患者旋转质子束剂量输送系统的等中心机架的尺寸。 ProCure 该项目的重点是使用现代机器人技术和高温超导磁体发明一种新的龙门概念，这将大大减少龙门的尺寸和质量，以及操作龙门所需的功率，从而减少这些龙门对设施成本的贡献。 ProCure 提议研究新技术，将龙门质量减少一个数量级，并将成本减少三倍。第一阶段研究将使 ProCure 能够基于新颖的光束扫描概念和强度调制质子治疗中使用的高温超导磁体技术，确定紧凑型低成本龙门架所需的最佳设计和组件。在第二阶段的前 12 个月中，ProCure 将致力于为选定的龙门概念构建原型磁体，构建关键的临时磁体支架和喷嘴组件，在第二阶段的接下来六个月中，ProCure 将在印第安纳大学回旋加速器设施最近委托使用的质子剂量测定测试设施中使用全尺寸系统进行实验。在第三阶段，ProCure 将在 IUCF 完成磁性和喷嘴操作的测试，并向 FDA 提交初步申请。 ProCure 将为龙门架建造第一个全旋转机械支撑系统原型，并安装完整系统进行机械系统测试。与此同时，ProCure 将启动首批安装系统的采购流程。最后，将进行 FDA 完整的系统测试，以获得 FDA 510k 的全面批准。公众健康相关性：质子治疗提供了使用放射控制和消除肿瘤的最佳选择，且短期和长期毒副作用最小；然而，只有不到 1% 的放射治疗患者接受质子治疗。进一步利用质子治疗的主要障碍是设施的规模和成本。 ProCure 的新质子束传输概念将大大减少系统的尺寸和质量以及操作系统所需的功率，从而有助于将这种高效的癌症治疗形式引入放射治疗的主流。