Training in Anti-Cancer Drug Development

这是一份申请，要求继续支持抗癌药物开发培训补助金， T32 CA 09243，目前已进入第30个年头。该计划由药理学系管理 约翰霍普金斯大学医学院的分子科学研究所，其目标是制备 在癌症相关药物领域从事研究和教学工作的博士前和博士后学生 发展* 博士前培训为高素质的学生提供综合课程，包括 课程工作和研究。在基础科学的核心课程的重组和振兴系列， 在第一年采取，包括分子生物学和基因组学，生物化学和生物物理 原理，大分子结构和分析，生物学中的有机机制，细胞结构和 动力学、途径和调控以及生物信息学。学生接受额外的指导， 通过在第二年所需的研究生药理学课程接触药理学和肿瘤学 一年，并通过选修课程，研讨会和期刊俱乐部。博士预科生选择一个教师 在他们的头两年，他们的导师和研究项目，并把大部分时间后，他们的 论文研究和获得书面和口头介绍他们的工作经验。博士后 受训人员将大部分时间用于更独立地进行的研究，但有适当的指导 从教师导师，为期一到三年。* 培训计划是跨学科的， 来自八个部门的教师：药理学和分子科学，肿瘤学，生物物理学和 生物物理化学、化学、分子生物学和遗传学、细胞生物学、泌尿学和环境 健康科学。学院建立的四个新研究中心促进了广泛的教师互动 基础生物医学科学研究所和共同的研究兴趣。广泛而富有成效 学生与教师和学生与学生之间的互动是通过研讨会，期刊俱乐部和学生- 相关活动，如招聘周末，研究务虚会，学生和教师的晚餐，并在教学， 除了实验室研究经验。* 自1979年开始，该培训方案已 支持了130多名博士前和博士后学员，其中大多数人已经在科学和 他们中的许多人在癌症研究领域担任领导角色。

This is an application requesting continued support for the Anti-Cancer Drug Development training grant, T32 CA09243, presently in its 30th year. The program is administered by the Department of Pharmacology & Molecular Sciences of the Johns Hopkins University, School of Medicine and its objective is to prepare pre- and postdoctoral students for research and teaching careers in the area of cancer-related drug development. *Predoctoral training provides highly qualified students with an integrated curriculum including course work and research. A reorganized and envigorated series of core courses in the basic sciences is taken during the first year and includes molecular biology and genomics, biochemical and biophysical principles, macromolecular structure and analysis, organic mechanisms in biology, cell structure and dynamics, pathways and regulation, and bioinformatics. Students receive additional instruction and exposure to pharmacology and oncology through a required graduate pharmacology course in the second year, and through elective courses, seminars, and journal clubs. Predoctoral trainees select a faculty preceptor and research project during their first two years, and devote most of their time after that to their thesis research and gaining experience with written and oral presentation of their work. Postdoctoral trainees devote most of their time to research carried out more independently, but with appropriate guidance from faculty mentors, for periods of one to three years. *The training program is interdisciplinary and brings together faculty from eight departments: Pharmacology & Molecular Sciences, Oncology, Biophysics & Biophysical Chemistry, Chemistry, Molecular Biology & Genetics, Cell Biology, Urology, and Environmental Health Sciences. Extensive faculty interaction is promoted by four new research Centers established by the Institute of Basic Biomedical Sciences and by common research interests. Extensive and productive student-faculty and student-student interactions are promoted by seminars, journal clubs, and by student- related activities such as recruiting weekends, research retreats, student-faculty dinners, and teaching, in addition to the laboratory research experience. *Since its beginning in 1979, this training program has supported over 130 pre-and postdoctoral trainees, most of whom have gone on to careers in science and many of whom have assumed leadership roles in the field of cancer research.