UCSD Cancer Center Training Program in Drug Development

7.项目摘要/摘要 本次续签申请寻求资金，以继续开展非常成功的癌症治疗培训(CT2) 加州大学圣地亚哥分校摩尔综合癌症中心的项目。这项使命 CT2计划的目的是培养博士和内科科学家，他们将成为下一代领导者 在癌症治疗和诊断领域，成功翻译所需的每一个主要步骤 将以实验室为基础的发现转化为安全有效的治疗剂和诊断方式。第二号货柜码头 培训旨在定位受训者在癌症发展领域发挥关键领导作用 治疗和诊断学。CT2项目的22名教员都是癌症中心的成员， 总部设在医学院、斯克里普斯海洋研究所或总医院的10个系 校园里。每一位教师导师都是一位成就卓著的研究人员和教育家，有着卓越的培训历史。 博士后研究员。每一家公司都有大量的同行评议的癌症或癌症相关研究资金。所有的 参与的教师正在进行翻译研究，他们之所以被选中，是因为他们对 新的癌症疗法。这项计划广泛地融入了美国癌症协会的其他癌症相关活动。 癌症中心和加州大学洛杉矶分校的。目标是在这两年内招聘和留住8名医学博士和博士科学家 该计划将使他们在开发新的抗癌药物或诊断所需的职业生涯中处于有利地位 以指导这些药物的使用。培训计划有3个组成部分：1)完成正式的教学 讲授药物开发过程中必不可少的工具；2)药物或药物的使用 在教师导师的指导下进行诊断开发研究项目；以及，3)需要参与 在美国癌症研究协会或同等国家药物的年度会议上 发展会议。受训人员还将参加癌症中心和科室 研讨会、研究回合和期刊俱乐部，以扩大他们对癌症研究的理解广度， 并编制正式的项目计划和做法或实际赠款申请，供执行委员会审查。 有方法确保所有受训人员接受负责任的行为原则的适当指导 研究和科学诚信。学员在全国范围内招募，并特别努力招募和 保留特殊的少数群体、妇女和弱势候选人。二号货柜码头在首四年的营运期间 该计划吸引了来自全国主要研究型大学和研究生的实习生 生物医学、血液学/肿瘤学、外科和放射学奖学金项目加州大学洛杉矶分校。这 该计划非常成功，以至于癌症中心建立了一个平行的计划，由其他 由捐款资助的癌症治疗研究奖学金。

7. PROJECT SUMMARY/ABSTRACT This renewal application seeks funding to continue the highly successful Cancer Therapeutics Training (CT2) Program at the Moores Comprehensive Cancer Center at the University of California, San Diego. The mission of the CT2 program is to train the PhD and physician-scientists who will become the next generation of leaders in the field of cancer therapeutics and diagnostics in each of the major steps required for successful translation of laboratory-based discoveries into safe and effective therapeutic agents and diagnostic modalities. The CT2 training is designed to position trainees to play key leadership roles in the field of cancer developmental therapeutics and diagnostics. The 22 faculty of the CT2 Program are all Members of the Cancer Center and are based in 10 departments in the School of Medicine, the Scripps Oceanographic Institute or the general campus. Each faculty mentor is an accomplished investigator and educator with a history of training superb post-doctoral fellows. Each has substantial peer-reviewed cancer or cancer-related research funding. All of the participating faculty are conducting translational research and have been selected because of their interest in new cancer therapeutics. This program is extensively integrated into the other cancer related activities of the Cancer Center and of UCSD. The goal is to recruit and retain 8 MD and PhD scientists in this two-year program that will position them for careers in the development of new cancer drugs or the diagnostics needed to guide the use of these drugs. The training program has 3 components: 1) the completion of formal didactic teaching sessions that cover tools essential to the drug development process; 2) the conduct of a drug or diagnostic development research project under the direction of a faculty mentor; and, 3) required participation in the annual meeting of the American Association for Cancer Research or an equivalent national drug development meeting. Trainees are also expected to participate in Cancer Center and Departmental seminars, research rounds and journal clubs to expand the breadth of their understanding of cancer research, and prepare formal project plans and practice or real grant applications for review by the Executive Committee. Methods are in place to ensure that all trainees are properly instructed in the principles of responsible conduct of research and scientific integrity. Trainees are recruited nationwide and special efforts are made recruit and retain exceptional minority, women and disadvantaged candidates. During its first 4 years of operation the CT2 Program has drawn trainees from major research universities across the country as well as from the Gradate Biomedical Sciences, Hematology/Oncology, Surgery and Radiology fellowship programs UCSD. This Program has been so successful that the Cancer Center has established a parallel program of additional fellowships in cancer therapeutics funded by donations.