NICHD Pelvic Floor Disorders Network Clinical Sites (U10)

本申请描述了德克萨斯大学西南医学中心和帕克兰医院的女性骨盆医学和重建外科（FPMRS）教师和研究团队的资格和经验，以及可用于执行盆底疾病网络（PFDN）赞助的临床方案的设施和患者群体。UT西南FPMRS部门包括4名全职教师医生，1名全职基础科学家和4名全职泌尿妇科护士。此外，泌尿外科、结直肠外科和物理治疗部门为许多盆底疾病患者提供护理，并与FPMRS部门保持积极的临床和研究合作。2009年，有2160名患有盆底疾病的妇女在FPMRS诊所就诊。378名妇女接受了手术治疗盆底疾病，1782名妇女接受了非手术治疗。本申请中描述的临床研究团队参与了前5年的PFDN周期，并为每项PFDN临床试验招募了大量人员。我们的临床和研究诊所针对私人患者（UT西南）和医疗贫困患者（帕克兰医院）。这些诊所提供多样化的患者群体，这使我们成为PFDN中西班牙裔患者的主要招募者。我们的研究团队中独一无二的是一位泌尿妇科基础和转化科学家。通过这种合作，我们的站点领导了为PFDN开发和实施ABC生物库的努力，该库现在位于德克萨斯大学西南分校。在过去的5年周期中，我们一直积极参与PFDN的各个方面，包括概念提案，委员会参与和手稿准备。重要的是，德州大学西南医学院的FPMRS医生在哲学上致力于严格的对照试验，旨在客观地评估与PFDN使命一致的非手术和手术护理原则。

This application describes the qualifications and experience of the Female Pelvic Medicine and Reconstructive Surgery (FPMRS) faculty and research teams at the University of Texas Southwestern Medical Center and Parkland Hospital and the facilities and patient population available to carry out clinical protocols sponsored by the Pelvic Floor Disorders Network (PFDN). UT Southwestern's Division of FPMRS includes 4 full-time faculty physicians, 1 full-time basic scientist and 4 full-time urogynecology nurse-practitioners. Additionally, the Departments of Urology, Colorectal Surgery and Physical Therapy care for many patients with pelvic floor disorders and maintain an active clinical and research collaboration with the Division of FPMRS. In 2009, there were 2160 women with pelvic floor disorders seen in the FPMRS clinics. Three hundred seventy eight women underwent surgical procedures for correction of pelvic floor disorders and 1782 women were managed with non-surgical techniques. The clinical research team described in this application has participated in the previous 5 year cycle of the PFDN and has had robust recruitment for every PFDN clinical trial. Our clinical and research clinics are targeted at both private patients (UT Southwestern) and medically indigent patients (Parkland Hospital). These clinics provide a diverse patient population which has allowed us to be the leading recruiter of Hispanic patients in the PFDN. Unique to our research team is an urogynecology basic and translational scientist. Through this collaboration, our site has led the effort to develop and implement the ABC Biorepository for the PFDN, which is now housed at UT Southwestern. In the last 5 year cycle we have been active in all aspects of the PFDN including concept proposal, committee participation and manuscript preparation. Importantly, the FPMRS physicians at UT Southwestern are philosophically dedicated to rigorous controlled trials intended to objectively evaluate principles of non-surgical and surgical care consistent with the mission of the PFDN. Included in this application is a concept proposal for a randomized placebo-controlled trial of intravaginal estrogen therapy as an adjunct to sacrocolpopexy for prevention of recurrent pelvic organ prolapse. We believe this trial builds on the previous work of the PFDN and addresses several key research topics including postoperative management to maximize recovery and minimize recurrence of pelvic floor disorders. We are of the view that this trial is ideally suited for the PFDN and has the potential to improve the care of patients with pelvic floor disorders.