NICHD Pelvic Floor Disorders Network

NICHD 盆底疾病网络

• 批准号: 7495687
• 负责人: JOSEPH I SCHAFFER
• 金额: $ 22.87万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-12 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7495687
• 关键词: American; Area; Basic Science; Chairperson; Childbirth; Clinic; Clinical Protocols; Clinical Research; Clinical Trials; Collaborations; Colorectal Surgery; Comprehensive Health Care; Contracts; Discipline of obstetrics; Doctor of Medicine; Doctor of Philosophy; Evaluation; External anal sphincter structure; Faculty; Fecal Incontinence; Goals; Government; Gynecologic; Gynecology; Hospitals; Human Resources; Injury; Joints; Laceration; Leadership; Letters; Medical; Medical Indigency; Medical center; Medicine; Muscle function; National Institute of Child Health and Human Development; Numbers; Obstetrics Departments; Oncology Group; Operative Surgical Procedures; Outcome; Patients; Pelvic Floor Disorders; Pelvic floor structure; Pelvis; Physical therapy; Population; Prevention strategy; Principal Investigator; Prostate; Prostatic; Radiology Specialty; Randomized Controlled Clinical Trials; Reproductive Medicine; Research; Research Personnel; Societies; Specific qualifier value; Sphincter; Surgeon; Symptoms; Texas; United States; United States National Institutes of Health; Universities; Urinary Incontinence; Urology; Woman; concept; design; experience; fetal; interest; member; professor; repaired; sphincter ani muscle structure

DESCRIPTION (provided by applicant): This application describes the qualifications and experience of the urogynecology and urology faculty and research teams at the University of Texas Southwestern (UT Southwestern) Medical Center and Parkland Hospital and the facilities and patient population available to carry out clinical protocols sponsored by the Pelvic Floor Disorders Network. In 2004, there were more than 2,100 women with pelvic floor disorders seen in our clinics and 617 women underwent surgical procedures for correction of pelvic floor disorders. The Departments of Obstetrics and Gynecology and Urology have increasingly collaborated since 1997 to offer comprehensive care of women with pelvic floor disorders. In addition to urogynecology and urology, collaboration includes faculty from colorectal surgery, radiology, physical therapy, and maternal-fetal medicine. The clinical research teams described in this application have successful prior as well as on-going experience in NIH sponsored national multi-center trials. Centerpieces in this application are two existing research clinics, one targeted at private patients (operated by the Urology Department) and the other focused on medically indigent patients (operated by the Obstetrics and Gynecology Department). Also included in this application is a concept application for a randomized trial designed to assess the efficacy of end-to-end versus overlapping repair of the external anal sphincter lacerated during childbirth. The primary outcome is anal incontinence which is a significant consequence of such lacerations. This trial would permit accurate evaluation of the outcome of specific surgical procedures which is one of the prime areas of interest leading to creation of the Pelvic Floor Disorders Network. We are of the view that along with strategies for prevention of anal sphincter laceration during childbirth, optimal management of the torn sphincter should also be studied since more than 200,000 women sustain such pelvic floor injuries each year in the United States.

描述（由申请人提供）：本申请描述了德克萨斯大学西南医学中心和帕克兰医院的泌尿妇科和泌尿外科教师和研究团队的资格和经验，以及可用于执行骨盆底疾病网络赞助的临床方案的设施和患者人数。2004年，有2100多名患有盆底疾病的妇女在我们的诊所就诊，617名妇女接受了盆底疾病矫正手术。自1997年以来，妇产科和泌尿外科越来越多地合作，为患有盆底疾病的妇女提供全面的护理。除了泌尿妇科和泌尿外科，合作还包括来自结直肠外科、放射学、物理治疗和母胎医学的教师。本申请中描述的临床研究团队在美国国立卫生研究院赞助的国家多中心试验中有成功的经验。该应用程序的核心是两个现有的研究诊所，一个针对私人患者（由泌尿科操作），另一个专注于医疗贫困患者（由妇产科操作）。该申请还包括一项随机试验的概念申请，旨在评估分娩期间撕裂的外肛门括约肌端到端修复与重叠修复的疗效。主要结果是肛门失禁，这是这种撕裂的显著后果。该试验将允许对特定外科手术的结果进行准确评估，这是创建盆底疾病网络的主要兴趣领域之一。我们认为，除了预防分娩时肛门括约肌撕裂的策略外，还应该研究撕裂括约肌的最佳处理方法，因为在美国每年有超过20万名妇女遭受这种盆底损伤。