Oogonial Stem Cell Characterization in POI and NHP

在这个令人兴奋的新兴领域，在过去的一年里，我们投入了大量的时间来建立人类和动物协议以及基础科学技术，以便在我们的实验室开始这条新的研究路线。

In this exciting, burgeoning field, over the past year we have invested substantial time in establishing human and animal protocols as well as basic science techniques to begin this new line of investigation in our laboratory. To examine the potential of putative stem cells, over the past year we have started a non-human primate oogonial model in our lab. Current efforts are devoted towards harvesting of ovarian tissue and establishing oogonial stem cell isolation and culture techniques. In humans, our aim is to study these cells in a disease model of primary ovarian insufficiency/ premature ovarian failure, diminished ovarian reserve and iatrogenically induced ovarian failure. Over the past year we have started an IRB approved protocol to collect ovarian tissues from women with these conditions. We will begin enrolling patients for this study shortly.