Enhancing Core Animal Facilities to Promote Biosecurity and Biosafety

加强核心动物设施以促进生物安全

• 批准号: 8185697
• 负责人: SUE VANDEWOUDE
• 金额: $ 35.83万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-09 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8185697
• 关键词: 20 year old; Animals; Area; Biomedical Research; Cavia; Colorado; Commit; Communicable Diseases; Containment; Development; Extramural Activities; Faculty; Funding; Grant; Health; Housing; Human; Laboratory Research; Maintenance; Malignant Neoplasms; Principal Investigator; Request for Proposals; Research; Therapeutic Studies; Universities; Vaccines; Wing; animal facility; biosecurity; member; mycobacterial

DESCRIPTION (provided by applicant): This proposal outlines aims to enhance the biosecurity and biocontainment capacity of the primary centralized animal facility at Colorado State University (Painter Center). Specifically, the proposal requests funds to: (1) acquire an oversized (36"W x 62"H x 73"D) bulk sterilizer for the cagewash facility to replace a >20 year old significantly smaller machine (24"W x 36"H x 48"D) that is no longer serviceable; and, (2) renovate the entry/exit area of a specialized wing of the animal facility, currently housing guinea pigs at Animal Biosafety Level 3 containment for Mycobacterial vaccine and therapeutic studies. This proposal will serve 96 identified principal investigators from twelve academic departments with over $130.5M in current extramural grant support, including nearly a dozen faculty member of the world-renowned Mycobacterial Research Laboratories ($54.8M total current funding). CSU recorded a record $303M research portfolio in FY10, an increase of 50% over the past 5 years. Because of the University's focus on infectious disease, cancer, and other biomedical research initiatives, this project will enhance a large portfolio of studies conducted to benefit human health. Consistent with a strong record of support for development and maintenance of state of the art animal facilities, the Vice President for Research has committed funds for renovation of the cagewash to accommodate the autoclave installation requested in this application. The Institutional Biosafety Officer also strongly supports the aims outlined in this proposal that will allow significant biosecurity enhancements to proceed. Construction will be managed with strict consideration of sustainable concepts directed by a LEED Accredited Facilities Professional Project Manager.

描述(由申请人提供)：本提案概述旨在加强科罗拉多州立大学(Painter Center)主要集中式动物设施的生物安全和生物遏制能力。具体地说，该提案要求资金：(1)为笼子洗涤设施购买一个超大(36“W x 62”H x 73“D)散装灭菌器，以取代一台已有20年历史的不再能使用的小得多的机器(24”W x 36“H x 48”D)；以及(2)翻新动物设施专门侧翼的进出区域，目前收容动物生物安全3级容器的豚鼠，用于分枝杆菌疫苗和治疗研究。这项提案将为来自12个学术部门的96名确定的首席研究人员提供服务，目前的外部资助超过1.305亿美元，其中包括世界著名的分枝杆菌研究实验室的近12名教职员工(目前的资金总额为5480万美元)。CSU在2010财年记录了创纪录的3.03亿美元的研究投资组合，在过去5年中增长了50%。由于该大学专注于传染病、癌症和其他生物医学研究计划，该项目将加强一大批有益于人类健康的研究。与支持开发和维护最先进的动物设施的良好记录一致，负责研究的副总裁承诺为翻新洗碗槽提供资金，以适应本申请中要求的高压灭菌器安装。机构生物安全干事还强烈支持这项提案中概述的目标，这些目标将使生物安全得到显著加强。施工管理将严格考虑由LEED认可的设施专业项目经理指导的可持续概念。