Enhancing Core Animal Facilities to Promote Biosecurity and Biosafety

加强核心动物设施以促进生物安全

• 批准号: 8185697
• 负责人: SUE VANDEWOUDE
• 金额: $ 35.83万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-09 至 2014-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8185697
• 关键词: 20 year old; Animals; Area; Biomedical Research; Cavia; Colorado; Commit; Communicable Diseases; Containment; Development; Extramural Activities; Faculty; Funding; Grant; Health; Housing; Human; Laboratory Research; Maintenance; Malignant Neoplasms; Principal Investigator; Request for Proposals; Research; Therapeutic Studies; Universities; Vaccines; Wing; animal facility; biosecurity; member; mycobacterial

DESCRIPTION (provided by applicant): This proposal outlines aims to enhance the biosecurity and biocontainment capacity of the primary centralized animal facility at Colorado State University (Painter Center). Specifically, the proposal requests funds to: (1) acquire an oversized (36"W x 62"H x 73"D) bulk sterilizer for the cagewash facility to replace a >20 year old significantly smaller machine (24"W x 36"H x 48"D) that is no longer serviceable; and, (2) renovate the entry/exit area of a specialized wing of the animal facility, currently housing guinea pigs at Animal Biosafety Level 3 containment for Mycobacterial vaccine and therapeutic studies. This proposal will serve 96 identified principal investigators from twelve academic departments with over $130.5M in current extramural grant support, including nearly a dozen faculty member of the world-renowned Mycobacterial Research Laboratories ($54.8M total current funding). CSU recorded a record $303M research portfolio in FY10, an increase of 50% over the past 5 years. Because of the University's focus on infectious disease, cancer, and other biomedical research initiatives, this project will enhance a large portfolio of studies conducted to benefit human health. Consistent with a strong record of support for development and maintenance of state of the art animal facilities, the Vice President for Research has committed funds for renovation of the cagewash to accommodate the autoclave installation requested in this application. The Institutional Biosafety Officer also strongly supports the aims outlined in this proposal that will allow significant biosecurity enhancements to proceed. Construction will be managed with strict consideration of sustainable concepts directed by a LEED Accredited Facilities Professional Project Manager.

描述（由申请人提供）：本提案概述了旨在提高科罗拉多州立大学（画家中心）主要集中动物设施的生物安全和生物控制能力。具体而言，该提案要求资金：(1)为笼洗设施购买一台超大型（36“宽x 62”高x 73“高）散装消毒器，以取代一台20年前的体积更小的机器（24“宽x 36”高x 48“深），该机器已不再可用；(2)整修动物设施的一个专门侧翼的出入口区域，该设施目前饲养着用于分枝杆菌疫苗和治疗研究的动物生物安全3级控制的豚鼠。该提案将为来自12个学术部门的96名确定的主要研究人员提供超过1.305亿美元的当前校外资助支持，其中包括世界知名的分枝杆菌研究实验室的近12名教员（当前资金总额为5480万美元）。CSU在2010财年记录了创纪录的3.03亿美元的研究投资组合，比过去5年增长了50%。由于该大学专注于传染病，癌症和其他生物医学研究计划，该项目将加强对人类健康有益的大量研究组合。与支持发展和维护最先进动物设施的强有力记录一致，研究副总裁已承诺翻新笼洗，以适应本应用程序中要求的高压灭菌器安装。机构生物安全干事也强烈支持本提案中概述的目标，这些目标将允许进行重大的生物安全加强。建筑将由LEED认证的设施专业项目经理严格考虑可持续发展概念进行管理。