Biosecurity Enhancements for the Rocky Mountain Regional Biocontainment Laborator

落基山地区生物防护实验室的生物安全增强

• 批准号: 7629393
• 负责人: SUE VANDEWOUDE
• 金额: $ 47.84万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2011-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7629393
• 关键词: Animal Housing; Animals; Arboviruses; Area; Colorado; Containment; Disease; Emergency Situation; Equipment; Failure; Funding; Growth; Housing; Infectious Diseases Research; Institution; Laboratories; Laboratory Animals; Modeling; Movement; Mus; Principal Investigator; Process; Research; Research Support; Site; Sterilization for infection control; Universities; animal facility; biosecurity; mycobacterial; pathogen; square foot

DESCRIPTION (provided by applicant): This proposal outlines a plan for capacity building at the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University. The RMRBL is one component of the CSU Foothills Campus Infectious Disease Research Center (IDRC). By 2010, the IDRC will provide nearly 25,000 sq. ft of total animal space to serve the needs of over 30 current principal investigators and a dozen collaborative institutions. The IDRC supports research on select agents, emerging pathogens, arboviruses, and mycobacterial diseases at Animal Biosafety Levels 2 and 3, and as such, is a unique facility in the Rocky Mountain region, and nationally. We propose here to increase autoclave capacity at the RMRBL cagewash facility to optimize biosafety and biosecurity sterilization of animal caging and equipment. Installation of a large pass-through autoclave is proposed in an area adjacent to the RMRBL animal facility that will also allow emergency redundancy sterilization in the case of failure of the primary decontaminating autoclave. The size and footprint of the proposed equipment is modeled after a highly functional autoclave located in another cagewash facility on campus, allowing equipment redundancy and proof of concept for the proposed machinery. Funding is also requested for movable animal caging to provide high-level containment housing for species other than mice, and transport housing for animal movement between holding areas and manipulation space. Altogether this proposal will fully equip the IDRC, allowing for projected growth of animal use, and the capacity to efficiently and effectively process equipment needed for specialized research performed at the site.

描述(由申请人提供)：本提案概述了科罗拉多州立大学落基山区域生物遏制实验室(RMRBL)的能力建设计划。RMRBL是CSU山麓校园传染病研究中心(IDRC)的一个组成部分。到2010年，红十字国际中心将提供近25,000平方米。英国《金融时报》提供了总的动物空间，以满足目前30多名主要研究人员和12个合作机构的需求。IDRC支持动物生物安全2级和3级的精选制剂、新出现的病原体、虫媒病毒和分枝杆菌疾病的研究，因此，它是落基山地区和全国独一无二的设施。我们在这里建议增加RMRBL笼子洗涤设施的高压灭菌器容量，以优化动物笼和设备的生物安全和生物安全灭菌。建议在RMRBL动物设施附近的区域安装大型直通式高压灭菌器，以便在主要净化灭菌器发生故障的情况下进行紧急冗余灭菌。拟议设备的大小和占地面积仿照位于校园内另一个洗罐设施的高功能高压灭菌器，以实现设备冗余和拟议机械的概念验证。还要求为可移动的动物笼子提供资金，以便为老鼠以外的其他物种提供高水平的隔离住房，并为动物在等待区和操纵空间之间的活动提供运输住房。总之，这项提议将使IDRC充分装备，允许动物使用的预计增长，并有能力高效和有效地处理在现场进行的专门研究所需的设备。