Biosecurity Enhancements for the Rocky Mountain Regional Biocontainment Laborator

落基山地区生物防护实验室的生物安全增强

• 批准号: 7629393
• 负责人: SUE VANDEWOUDE
• 金额: $ 47.84万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2011-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7629393
• 关键词: Animal Housing; Animals; Arboviruses; Area; Colorado; Containment; Disease; Emergency Situation; Equipment; Failure; Funding; Growth; Housing; Infectious Diseases Research; Institution; Laboratories; Laboratory Animals; Modeling; Movement; Mus; Principal Investigator; Process; Research; Research Support; Site; Sterilization for infection control; Universities; animal facility; biosecurity; mycobacterial; pathogen; square foot

DESCRIPTION (provided by applicant): This proposal outlines a plan for capacity building at the Rocky Mountain Regional Biocontainment Laboratory (RMRBL) at Colorado State University. The RMRBL is one component of the CSU Foothills Campus Infectious Disease Research Center (IDRC). By 2010, the IDRC will provide nearly 25,000 sq. ft of total animal space to serve the needs of over 30 current principal investigators and a dozen collaborative institutions. The IDRC supports research on select agents, emerging pathogens, arboviruses, and mycobacterial diseases at Animal Biosafety Levels 2 and 3, and as such, is a unique facility in the Rocky Mountain region, and nationally. We propose here to increase autoclave capacity at the RMRBL cagewash facility to optimize biosafety and biosecurity sterilization of animal caging and equipment. Installation of a large pass-through autoclave is proposed in an area adjacent to the RMRBL animal facility that will also allow emergency redundancy sterilization in the case of failure of the primary decontaminating autoclave. The size and footprint of the proposed equipment is modeled after a highly functional autoclave located in another cagewash facility on campus, allowing equipment redundancy and proof of concept for the proposed machinery. Funding is also requested for movable animal caging to provide high-level containment housing for species other than mice, and transport housing for animal movement between holding areas and manipulation space. Altogether this proposal will fully equip the IDRC, allowing for projected growth of animal use, and the capacity to efficiently and effectively process equipment needed for specialized research performed at the site.

描述（由申请人提供）：该提案概述了科罗拉多州立大学落基山地区生物防护实验室 (RMRBL) 的能力建设计划。 RMRBL 是科罗拉多州立大学山麓校区传染病研究中心 (IDRC) 的组成部分之一。到 2010 年，IDRC 将提供近 25,000 平方英尺的总动物空间，以满足 30 多名现任主要研究人员和十几个合作机构的需求。 IDRC 支持动物生物安全 2 级和 3 级的特定病原体、新出现的病原体、虫媒病毒和分枝杆菌疾病的研究，因此是落基山脉地区乃至全国独一无二的机构。我们在此建议增加 RMRBL 笼洗设施的高压灭菌器容量，以优化动物笼具和设备的生物安全和生物安保灭菌。建议在 RMRBL 动物设施附近的区域安装大型直通式高压灭菌器，以便在主要净化高压灭菌器发生故障的情况下进行紧急冗余灭菌。拟议设备的尺寸和占地面积是根据校园内另一个笼洗设施中的功能强大的高压灭菌器建模的，从而允许设备冗余和拟议机械的概念验证。还需要资金用于可移动的动物笼舍，为除小鼠以外的物种提供高级收容室，以及用于动物在饲养区和操作空间之间移动的运输室。总而言之，该提案将为 IDRC 提供充分的装备，从而实现动物使用的预计增长，以及高效且有效地处理现场进行的专门研究所需设备的能力。