Improving Animal Resources at the University of Georgia

改善佐治亚大学的动物资源

• 批准号: 8185262
• 负责人: Christopher Simon King
• 金额: $ 37.1万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8185262
• 关键词: Affect; Agriculture; Animals; Caring; Censuses; Ecology; Equipment; Faculty; Funding; Future; Grant; Growth; Health; Health Sciences; Home environment; Housing; Investments; Laboratories; Mus; Research; Research Project Grants; Rodent; Rodent Model; Science; Source; System; Time; United States National Institutes of Health; Universities; aged; animal care; animal resource; base; cost; improved; meetings; prevent; programs

DESCRIPTION (provided by applicant): Improving Animal Resources at the University of Georgia The University of Georgia (UGA) is a large research-intensive, land-grant university with historic strengths in the agricultural and environmental sciences. For over a decade, UGA has prioritized the expansion and strengthening of its biomedical and health-related programs, and this has in turn produced a dramatic growth in the use of laboratory rodents, particularly mice. This growth has occurred at the same time we have moved to consolidate and upgrade laboratory rodent care in the modern and efficient vivarium housed in the new Paul D. Coverdell Center for Biomedical & Health Sciences. The Coverdell Rodent Vivarium (CRV) is a large state-of-the-art barrier facility that if properly equipped can replace aged, dispersed and haphazardly equipped conventional facilities to become the flagship home for laboratory rodents in UGA's AAALAC-accredited animal care and use program. Sizeable investments by UGA in recent years have enabled considerable progress towards the equipping of the CRV but recent fiscal austerity has prevented full utilization of the facility and also impaired efforts to keep pace with equipment needs for near term and projected research growth. The specific aim is to provide individually ventilated rodent caging (IVC) systems, biosafety cabinets and ventilated change stations to enhance and extend the capabilities of the Coverdell Rodent Vivarium (CRV) to meet research needs. Despite successive investments in new IVC systems, housing now available in the CRV is sufficient only to meet current needs, with no additional capacity available for new grants already approved for funding or for new programmatic growth resulting from planned new faculty hires. The strain has been exacerbated by the need to downsize or close a number of outdated and inefficient rodent facilities, and to largely consolidate rodent care in the modern efficient Coverdell Rodent Vivarium, which now houses over 80% of the campus rodent census. The equipment requested in this proposal will allow us to meet foreseeable future growth in the use of laboratory rodent models as the biomedical sciences at UGA continue to expand. We project that the CRV mouse census will grow by 41% during the next year. The requested equipment will provide 37% additional capacity. The improvements proposed will directly affect $12.7 million in active NIH funding and $20.9 million in funding from all other sources, both federal and non-federal. UGA's total funding for animal-based research reached $29.8 million in FY2010, increasing over 100% from just four years ago. Funding for 14 additional Tecniplast Sealsafe IVC racks and caging is being sought to provide an additional 1840 cages or 37% of additional capacity. Funding for 4 additional 4' Class IIA2 BSCs and 5 additional ventilated change stations is requested to enhance animal holding capabilities. The total cost of the equipment is $670,880. A total of $500,000 is requested with UGA providing a 34% match of $170,880.

描述（由申请人提供）：改善动物资源在格鲁吉亚的大学（UGA）的格鲁吉亚的大学是一个大型的研究密集型，赠地大学在农业和环境科学的历史优势。十多年来，UGA优先考虑扩大和加强其生物医学和健康相关的计划，这反过来又产生了实验室啮齿动物，特别是小鼠的使用急剧增长。这一增长是在我们采取行动巩固和提升实验室啮齿动物护理的同时发生的，现代化和高效的动物饲养场设在新的保罗D。Coverdell生物医学与健康科学中心。该Coverdell啮齿动物饲养场（CRV）是一个大型的国家的最先进的屏障设施，如果装备得当，可以取代老化，分散和hapazardous装备的传统设施，成为旗舰家实验室啮齿动物在UGA的AAALAC认可的动物护理和使用计划。近年来，佐治亚大学的大量投资使CRV的装备取得了相当大的进展，但最近的财政紧缩阻碍了该设施的充分利用，也削弱了满足短期设备需求和预计研究增长的努力。具体目标是提供单独通风的啮齿动物笼（IVC）系统，生物安全柜和通风更换站，以增强和扩展Coverdell啮齿动物饲养所（CRV）的能力，以满足研究需求。尽管在新的IVC系统连续投资，住房现在在CRV是足以满足当前的需求，没有额外的能力可用于新的赠款已经批准的资金或新的计划增长所造成的新的教师招聘。由于需要缩小规模或关闭一些过时和低效的啮齿动物设施，并在现代高效的Coverdell啮齿动物饲养场（Coverdell Rodent Vivarium）中大量巩固啮齿动物护理，该饲养场目前容纳了80%以上的校园啮齿动物普查，这种压力加剧了。本提案中要求的设备将使我们能够满足实验室啮齿动物模型使用的可预见的未来增长，因为UGA的生物医学科学继续扩大。我们预计，CRV小鼠普查将在明年增长41%。所要求的设备将提供37%的额外容量。提议的改进将直接影响NIH的1270万美元的积极资金和来自所有其他来源的2090万美元的资金，包括联邦和非联邦。UGA的动物为基础的研究资金总额达到2980万美元在2010财年，从四年前增加了100%以上。正在寻求为14个额外的Tecniplast Sealsafe IVC机架和笼子提供资金，以提供额外的1840个笼子或37%的额外容量。要求拨款增加4个4' Class IIA 2 BSC和5个通风转换站，以提高动物容纳能力。设备费用共计670 880美元。一个$500，000的要求与UGA提供了$170，880的34%匹配。