It's Complex! Engaging Student Discussions around Complex Genetics and Individual

描述（由申请人提供）：这是复杂的!将帮助亚拉巴马高中学生识别疾病的遗传和环境风险，并探索风险意识如何塑造疾病预防。科学家们已经开始检测影响糖尿病、高血压、肥胖和多种癌症等复杂疾病的遗传和环境因素。风险因素的知识有助于医生和患者选择最佳的管理或预防措施。Hudson-Alpha生物技术研究所将创建和实施Risky Business，这是一项在线活动，旨在探索基因检测，风险确定和预防/治疗方案的世界。学生将承担家庭医生的角色，与最近接受过几种复杂疾病基因组检测的患者一起工作。学生将审查家族史，医疗记录，视频访谈和遗传信息，以确定遗传和环境风险。总的来说，这些风险将被用来确定减少疾病发生机会的医疗和生活方式建议。这项活动连接到学生学习遗传变异，复杂的遗传和生物技术对医疗实践的贡献-亚拉巴马和国家科学标准的关键组成部分。引人入胜的互动形式提供了自我导向的学习，内容管理系统允许通过定期更新添加新的研究发现或临床应用。在线视频、动画、访谈和职业简介将为学生和教育工作者提供支持，并将内容与生物科学竞技场的劳动力机会联系起来。最初的实施将集中在亚拉巴马学校，接触到传统上在生物医学领域代表性不足的学生。教师指导将通过研讨会和嵌入式培训进行，并在第四年之前建立一个完全在线的培训模块。亚拉巴马数学科学和技术倡议，全州范围内的材料和专业发展计划将有助于促进全州范围内的培训，更广泛的传播发生在第五年。在不久的将来，个人遗传信息将成为医疗记录中与血压、BMI和胆固醇一样重要的一部分。该提案中概述的活动旨在创造一个更有遗传学素养的公民，提高对生物科学作为职业可能性的认识，并为鼓励学生采取预防性行为，减少复杂疾病的风险提供了宝贵的第一步。 公共卫生相关性（由申请人提供）：这项在线活动和支持资源为学生提供了有关糖尿病，高血压，几种癌症和肥胖症等疾病风险的重要信息。虽然这些风险的一部分是由于遗传因素从我们的父母，其他风险源于我们的生活方式的选择，如饮食，运动和吸烟。旨在确定这些风险的研究得到了NIH的大力支持，主题与州和国家科学标准有关。了解遗传和生活方式因素相互作用，并认识到预防行为如何降低疾病风险，为学生做出与健康相关的决定提供了关键信息。

DESCRIPTION (provided by applicant): It's Complex! will assist Alabama high school students in identifying genetic and environmental risks for disease and exploring how risk awareness shapes disease prevention. Scientists have begun to detect genetic and environmental factors that influence complex diseases such as diabetes, hypertension, obesity, and many forms of cancer. Knowledge of risk factors aids physicians and their patients in selecting the best course of action for management or prevention. The Hudson-Alpha Institute for Biotechnology will create and implement Risky Business, an online activity that explores the world of genetic testing, risk determination and prevention/treatment options. Students will assume the role of a family physician, working with patients whom have recently undergone genomic testing for several complex disorders. Students will review family history, medical records, video interviews and genetic information to ascertain genetic and environmental risks. Collectively, these risks will be used to identify medical and lifestyle recommendations that reduce the chance of developing the disease. This activity connects to student learning for genetic variation, complex inheritance and the contributions of biotechnology to medical practice - key components of both Alabama and national science standards. The engaging interactive format offers self-directed learning and a content management system allows new research findings or clinical applications to be added through regular updates. Online videos, animations, interviews and career profiles will support both students and educators and link content to workforce opportunities in the bioscience arena. Initial implementation will focus on Alabama schools that reach students who are traditionally underrepresented in the biomedical field. Teacher instruction will occur through workshops and embedded training with a fully-online training module in place by year four. The Alabama Math Science and Technology Initiative, a statewide materials and professional development program will help facilitate the statewide training, with broader dissemination occurring in year five. In the not-too-distant future, personal genetic information will be as important a part of a medical record as blood pressure, BMI and cholesterol. The activities outlined in this proposal seek to create a more genetically literate citizenry, increase awareness of bioscience as a career possibility, and provide a valuable first step in encouraging students to adopt preventative behaviors that reduce the risk of complex disorders. PUBLIC HEALTH RELEVANCE (provided by applicant): This online activity and supporting resources provides students with important information about the risks for diseases such as diabetes, hypertension, several forms of cancer and obesity. While a portion of these risks are due to genetic factors inherited from our parents, other risks stem from the lifestyle choices we make, such as diet, exercise and smoking. Research aimed at identifying these risks is strongly supported by the NIH and the topics link to state and national science standards. Understanding that genetic and lifestyle factors interact and realizing how preventative behavior may reduce disease risk offers critical information to students making health-related decisions.