It's Complex! Engaging Student Discussions around Complex Genetics and Individual

描述(申请人提供)：很复杂！将帮助阿拉巴马州的高中生识别疾病的遗传和环境风险，并探索风险意识如何影响疾病预防。科学家已经开始检测影响糖尿病、高血压、肥胖症和多种癌症等复杂疾病的遗传和环境因素。对风险因素的了解有助于医生和他们的病人选择最佳的管理或预防措施。哈德逊-阿尔法生物技术研究所将创建和实施Risk Business，这是一个探索基因检测、风险确定和预防/治疗选择的在线活动。学生将扮演家庭医生的角色，为最近接受了几种复杂疾病的基因组测试的患者工作。学生将复习家族史、医疗记录、视频访谈和遗传信息，以确定遗传和环境风险。总而言之，这些风险将被用来确定降低疾病发生几率的医疗和生活方式建议。这项活动与学生学习遗传变异、复杂遗传和生物技术对医疗实践的贡献有关--这些都是阿拉巴马州和国家科学标准的关键组成部分。引人入胜的互动形式提供自我指导的学习，内容管理系统允许通过定期更新添加新的研究成果或临床应用。在线视频、动画、采访和职业简介将为学生和教育工作者提供支持，并将内容与生物科学领域的劳动力机会联系起来。最初的实施将集中在阿拉巴马州的学校，这些学校的学生传统上在生物医学领域的代表性不足。教师培训将通过讲习班和嵌入式培训进行，并在四年前建立一个完全在线的培训模块。阿拉巴马州数学科学和技术倡议是一项全州范围的材料和专业发展计划，将帮助促进全州范围的培训，更广泛的传播将在第五年进行。在不太遥远的将来，个人基因信息将像血压、BMI和胆固醇一样成为医疗记录的重要组成部分。该提案中概述的活动旨在创造一个更具基因素养的公民群体，提高人们对生物科学作为一种职业可能性的认识，并在鼓励学生采取预防行为以降低复杂疾病风险方面迈出宝贵的第一步。 公共卫生相关性(由申请者提供)：这个在线活动和支持资源为学生提供有关糖尿病、高血压、几种形式的癌症和肥胖症等疾病风险的重要信息。虽然这些风险的一部分是由于遗传自父母的遗传因素，但其他风险源于我们选择的生活方式，如饮食、锻炼和吸烟。旨在识别这些风险的研究得到了美国国立卫生研究院的大力支持，这些课题与州和国家科学标准相联系。了解遗传和生活方式因素的相互作用，并认识到预防性行为如何降低疾病风险，为学生做出与健康有关的决定提供了关键信息。

DESCRIPTION (provided by applicant): It's Complex! will assist Alabama high school students in identifying genetic and environmental risks for disease and exploring how risk awareness shapes disease prevention. Scientists have begun to detect genetic and environmental factors that influence complex diseases such as diabetes, hypertension, obesity, and many forms of cancer. Knowledge of risk factors aids physicians and their patients in selecting the best course of action for management or prevention. The Hudson-Alpha Institute for Biotechnology will create and implement Risky Business, an online activity that explores the world of genetic testing, risk determination and prevention/treatment options. Students will assume the role of a family physician, working with patients whom have recently undergone genomic testing for several complex disorders. Students will review family history, medical records, video interviews and genetic information to ascertain genetic and environmental risks. Collectively, these risks will be used to identify medical and lifestyle recommendations that reduce the chance of developing the disease. This activity connects to student learning for genetic variation, complex inheritance and the contributions of biotechnology to medical practice - key components of both Alabama and national science standards. The engaging interactive format offers self-directed learning and a content management system allows new research findings or clinical applications to be added through regular updates. Online videos, animations, interviews and career profiles will support both students and educators and link content to workforce opportunities in the bioscience arena. Initial implementation will focus on Alabama schools that reach students who are traditionally underrepresented in the biomedical field. Teacher instruction will occur through workshops and embedded training with a fully-online training module in place by year four. The Alabama Math Science and Technology Initiative, a statewide materials and professional development program will help facilitate the statewide training, with broader dissemination occurring in year five. In the not-too-distant future, personal genetic information will be as important a part of a medical record as blood pressure, BMI and cholesterol. The activities outlined in this proposal seek to create a more genetically literate citizenry, increase awareness of bioscience as a career possibility, and provide a valuable first step in encouraging students to adopt preventative behaviors that reduce the risk of complex disorders. PUBLIC HEALTH RELEVANCE (provided by applicant): This online activity and supporting resources provides students with important information about the risks for diseases such as diabetes, hypertension, several forms of cancer and obesity. While a portion of these risks are due to genetic factors inherited from our parents, other risks stem from the lifestyle choices we make, such as diet, exercise and smoking. Research aimed at identifying these risks is strongly supported by the NIH and the topics link to state and national science standards. Understanding that genetic and lifestyle factors interact and realizing how preventative behavior may reduce disease risk offers critical information to students making health-related decisions.