It's Complex! Engaging Student Discussions around Complex Genetics and Individual

很复杂！

• 批准号: 8258743
• 负责人: Neil Edward Lamb
• 金额: $ 26.58万
• 依托单位: HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8258743
• 关键词: Adopted; African American; Alabama; Awareness; Behavior; Biological Sciences; Biotechnology; Blood Pressure; Businesses; Cholesterol; Complex; Diabetes Mellitus; Discipline; Disease; Distant; Educational workshop; Environmental Risk Factor; Ethnic Origin; Family; Family Physicians; Future; Genetic; Genetic Medicine; Genetic Risk; Genetic Variation; Genetic screening method; Genomics; Health; Healthcare; Housing; Hypertension; Individual; Inherited; Institutes; Instruction; Interview; Knowledge; Learning; Life; Life Cycle Stages; Life Style; Link; Malignant Neoplasms; Medical; Medical Records; Medicine; Nature; Obesity; Outcome; Parents; Pathway interactions; Patients; Personal Genetic Information; Physicians; Prevention; Prevention strategy; Professional counselor; Program Development; Recommendation; Recording of previous events; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Schools; Science; Scientist; Shapes; Smoking; Students; System; Systems Development; Technology; Testing; Thinking; Training; Translating; United States National Institutes of Health; Update; Work; animation; career; clinical application; diet and exercise; disorder prevention; disorder risk; genetic risk factor; genetic technology; high school; lifestyle factors; literate; public health relevance; rural area; skills; stem; teacher; web site

DESCRIPTION (provided by applicant): It's Complex! will assist Alabama high school students in identifying genetic and environmental risks for disease and exploring how risk awareness shapes disease prevention. Scientists have begun to detect genetic and environmental factors that influence complex diseases such as diabetes, hypertension, obesity, and many forms of cancer. Knowledge of risk factors aids physicians and their patients in selecting the best course of action for management or prevention. The Hudson-Alpha Institute for Biotechnology will create and implement Risky Business, an online activity that explores the world of genetic testing, risk determination and prevention/treatment options. Students will assume the role of a family physician, working with patients whom have recently undergone genomic testing for several complex disorders. Students will review family history, medical records, video interviews and genetic information to ascertain genetic and environmental risks. Collectively, these risks will be used to identify medical and lifestyle recommendations that reduce the chance of developing the disease. This activity connects to student learning for genetic variation, complex inheritance and the contributions of biotechnology to medical practice - key components of both Alabama and national science standards. The engaging interactive format offers self-directed learning and a content management system allows new research findings or clinical applications to be added through regular updates. Online videos, animations, interviews and career profiles will support both students and educators and link content to workforce opportunities in the bioscience arena. Initial implementation will focus on Alabama schools that reach students who are traditionally underrepresented in the biomedical field. Teacher instruction will occur through workshops and embedded training with a fully-online training module in place by year four. The Alabama Math Science and Technology Initiative, a statewide materials and professional development program will help facilitate the statewide training, with broader dissemination occurring in year five. In the not-too-distant future, personal genetic information will be as important a part of a medical record as blood pressure, BMI and cholesterol. The activities outlined in this proposal seek to create a more genetically literate citizenry, increase awareness of bioscience as a career possibility, and provide a valuable first step in encouraging students to adopt preventative behaviors that reduce the risk of complex disorders. PUBLIC HEALTH RELEVANCE (provided by applicant): This online activity and supporting resources provides students with important information about the risks for diseases such as diabetes, hypertension, several forms of cancer and obesity. While a portion of these risks are due to genetic factors inherited from our parents, other risks stem from the lifestyle choices we make, such as diet, exercise and smoking. Research aimed at identifying these risks is strongly supported by the NIH and the topics link to state and national science standards. Understanding that genetic and lifestyle factors interact and realizing how preventative behavior may reduce disease risk offers critical information to students making health-related decisions.

描述（由申请人提供）：很复杂！将协助阿拉巴马州的高中生识别疾病的遗传和环境风险，并探索风险意识如何影响疾病预防。科学家们已经开始发现影响糖尿病、高血压、肥胖和多种癌症等复杂疾病的遗传和环境因素。了解危险因素有助于医生和患者选择最佳的治疗或预防措施。哈德逊-阿尔法生物技术研究所将创建并实施风险商业，这是一项在线活动，探索基因检测、风险确定和预防/治疗方案的世界。学生将扮演家庭医生的角色，与最近接受了几种复杂疾病基因组测试的患者一起工作。学生将回顾家族史、医疗记录、视频访谈和遗传信息，以确定遗传和环境风险。总的来说，这些风险将用于确定医疗和生活方式建议，以减少患该疾病的机会。这项活动与学生学习遗传变异、复杂遗传和生物技术对医疗实践的贡献有关，这些都是阿拉巴马州和国家科学标准的关键组成部分。引人入胜的互动形式提供自主学习，内容管理系统允许通过定期更新添加新的研究成果或临床应用。在线视频、动画、访谈和职业简介将为学生和教育工作者提供支持，并将内容与生物科学领域的就业机会联系起来。最初的实施将集中在阿拉巴马州的学校，这些学校的学生传统上在生物医学领域的代表性不足。教师指导将通过研讨会和嵌入式培训进行，到第四年将有一个完全在线的培训模块。阿拉巴马州数学科学和技术倡议是一个全州范围的材料和专业发展计划，将有助于促进全州范围的培训，并在第五年进行更广泛的传播。在不久的将来，个人基因信息将与血压、身体质量指数和胆固醇一样成为医疗记录的重要组成部分。本提案中概述的活动旨在培养更有基因知识的公民，提高对生物科学作为职业可能性的认识，并在鼓励学生采取减少复杂疾病风险的预防性行为方面提供有价值的第一步。