It's Complex! Engaging Student Discussions around Complex Genetics and Individual

很复杂！

• 批准号: 8663332
• 负责人: Neil Edward Lamb
• 金额: $ 17.55万
• 依托单位: HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8663332
• 关键词: Adopted; African American; Alabama; Awareness; Behavior; Biological Sciences; Biotechnology; Blood Pressure; Businesses; Cholesterol; Complex; Critical Thinking; Diabetes Mellitus; Discipline; Disease; Distant; E-learning; Educational workshop; Environmental Risk Factor; Ethnic Origin; Family; Family Physicians; Future; Genetic; Genetic Medicine; Genetic Risk; Genetic Variation; Genetic screening method; Genomics; Health; Healthcare; High School Student; Housing; Hypertension; Individual; Inherited; Institutes; Instruction; Interview; Knowledge; Learning; Life; Life Cycle Stages; Life Style; Link; Malignant Neoplasms; Medical; Medical Records; Medicine; Nature; Obesity; Outcome; Parents; Pathway interactions; Patients; Personal Genetic Information; Physicians; Prevention; Prevention strategy; Professional counselor; Program Development; Recommendation; Recording of previous events; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Schools; Science; Scientist; Shapes; Smoking; Students; System; Systems Development; Technology; Testing; Training; Translating; United States National Institutes of Health; Update; Work; animation; career; clinical application; diet and exercise; disorder prevention; disorder risk; genetic risk factor; genetic technology; high school; lifestyle factors; literate; mathematical sciences; rural area; skills; stem; teacher; web site

DESCRIPTION (provided by applicant): It's Complex! will assist Alabama high school students in identifying genetic and environmental risks for disease and exploring how risk awareness shapes disease prevention. Scientists have begun to detect genetic and environmental factors that influence complex diseases such as diabetes, hypertension, obesity, and many forms of cancer. Knowledge of risk factors aids physicians and their patients in selecting the best course of action for management or prevention. The Hudson-Alpha Institute for Biotechnology will create and implement Risky Business, an online activity that explores the world of genetic testing, risk determination and prevention/treatment options. Students will assume the role of a family physician, working with patients whom have recently undergone genomic testing for several complex disorders. Students will review family history, medical records, video interviews and genetic information to ascertain genetic and environmental risks. Collectively, these risks will be used to identify medical and lifestyle recommendations that reduce the chance of developing the disease. This activity connects to student learning for genetic variation, complex inheritance and the contributions of biotechnology to medical practice - key components of both Alabama and national science standards. The engaging interactive format offers self-directed learning and a content management system allows new research findings or clinical applications to be added through regular updates. Online videos, animations, interviews and career profiles will support both students and educators and link content to workforce opportunities in the bioscience arena. Initial implementation will focus on Alabama schools that reach students who are traditionally underrepresented in the biomedical field. Teacher instruction will occur through workshops and embedded training with a fully-online training module in place by year four. The Alabama Math Science and Technology Initiative, a statewide materials and professional development program will help facilitate the statewide training, with broader dissemination occurring in year five. In the not-too-distant future, personal genetic information will be as important a part of a medical record as blood pressure, BMI and cholesterol. The activities outlined in this proposal seek to create a more genetically literate citizenry, increase awareness of bioscience as a career possibility, and provide a valuable first step in encouraging students to adopt preventative behaviors that reduce the risk of complex disorders.

描述（由申请人提供）：很复杂！将帮助阿拉巴马州高中学生确定疾病的遗传和环境风险，并探索风险意识如何塑造疾病预防。科学家已经开始检测影响糖尿病，高血压，肥胖和多种形式癌症等复杂疾病的遗传和环境因素。风险因素的知识有助于医生及其患者选择最佳的管理或预防行动方案。 Hudson-Alpha生物技术研究所将创建和实施风险业务，这是一项在线活动，探讨基因测试，风险确定和预防/治疗方案的世界。学生将扮演家庭医生的角色，与最近对几种复杂疾病进行基因组测试的患者一起工作。学生将审查家族史，病历，视频访谈和遗传信息，以确定遗传和环境风险。总的来说，这些风险将用于确定医疗和生活方式的建议，以减少发展疾病的机会。这项活动与学生学习有关遗传变异，复杂的遗传以及生物技术对医学实践的贡献 - 阿拉巴马州和国家科学标准的关键组成部分。引人入胜的交互式格式提供了自我指导的学习，内容管理系统允许通过常规更新添加新的研究发现或临床应用程序。在线视频，动画，访谈和职业资料将支持学生和教育者，并将内容与生物科学领域的劳动力机会联系起来。最初的实施将集中在阿拉巴马州的学校中，这些学校传统上在生物医学领域的人数不足。教师的教学将通过研讨会和嵌入式培训进行，并在第四年到达全线培训模块。阿拉巴马州数学科学技术计划，一项全州材料和专业发展计划将有助于促进全州培训，而在五年级进行了更广泛的传播。在不太遥远的未来，个人遗传信息将与血压，BMI和胆固醇一样重要。该提案中概述的活动旨在创造一种更具遗传识字的公民，提高对生物科学的意识，并为鼓励学生采用预防行为，以减少复杂疾病的风险。