Combined radiation and traumatic injury affect hippocampal structure and function

辐射和创伤联合影响海马结构和功能

• 批准号: 8304978
• 负责人: JOHN R. FIKE
• 金额: $ 35.82万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-20 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8304978
• 关键词: Adverse effects; Affect; Anabolism; Area; Behavioral; Blast Cell; Bone Marrow; Brain; Cause of Death; Cells; Cognition; Cognitive; Cranial Irradiation; Cytoskeleton; DL-alpha-Difluoromethylornithine; Development; Dose; Hippocampus (Brain); Immediate-Early Genes; Impaired cognition; Impairment; Individual; Inflammation; Injury; Intervention; Learning; Mediating; Memory; Messenger RNA; Microglia; Molecular; Morphology; Nuclear; Organ; Pathogenesis; Performance; Polyamines; Proteins; Quality of life; Radiation; Radiation Injuries; Radiation Syndromes; Structure; Synaptic Transmission; Tissues; Traumatic Brain Injury; abstracting; behavior measurement; dentate gyrus; disability; improved; inhibitor/antagonist; irradiation; neurogenesis; neuroinflammation; radiation adverse effect; response; treatment strategy

No abstract provided

未提供摘要

项目成果

Delayed administration of alpha-difluoromethylornithine prevents hippocampus-dependent cognitive impairment after single and combined injury in mice.

• DOI: 10.1667/rr13753.1
• 发表时间: 2014-11
• 期刊: Radiation research
• 影响因子: 3.4
• 作者: Allen AR;Eilertson K;Sharma S;Baure J;Allen B;Leu D;Rosi S;Raber J;Huang TT;Fike JR
• 通讯作者: Fike JR