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Targeting P2X7 Receptor Antagonists for Prevention of Pancreatic Cancer

Targeting P2X7 Receptor Antagonists for Prevention of Pancreatic Cancer
靶向 P2X7 受体拮抗剂预防胰腺癌
批准号：
8760399
负责人：
TERISA DAVIS
金额：
$50.92万
依托单位：
--
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8760399
关键词：
Biological AssayBiological MarkersClinical ResearchContractorDoseGene Expression ProfileInflammatoryMalignant neoplasm of pancreasMaximum Tolerated DoseMessenger RNAMicroRNAsModificationMusPancreasPharmacodynamicsPhasePositron-Emission TomographyPre-Clinical ModelPreventionSerumSignal PathwayTestingTissuesTransgenic Micecancer preventioncytokineinhibitor/antagonistmouse modelreceptor

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中文摘要
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英文摘要
The overall objective of this task order is to evaluate specific inhibitors of P2X7R for pancreatic cancer prevention in preclinical models. Specifically, the contractor shall test 2 such inhibitors (AZ10606120 (HAQDT) and A438079) by first establishing the optimal dose and maximal tolerated dose (MTD) in mice and then assess the pancreatic cancer prevention efficacy in p48Cre/+-LSL-KrasG12D/+ transgenic mouse model of pancreatic cancer. In addition, test the modifications in inflammasome signal pathways and critical biomarkers of pharmacodynamic efficacy, which will be applicable to early-phase clinical studies.
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SCIENTIFIC SUPPORT SERVICES FOR THE NATIONAL CANCER INSTITUTE, DIVISIOIN OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS)
  • 批准号：
    10458431
  • 项目类别：
  • 资助金额：
    $222.97万
  • 财政年份：
    2020
  • 负责人：
    TERISA DAVIS
  • 依托单位：
    WESTAT, INC.
SCIENTIFIC SUPPORT SERVICES FOR THE NATIONAL CANCER INSTITUTE, DIVISIOIN OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS)
  • 批准号：
    10225274
  • 项目类别：
  • 资助金额：
    $277.91万
  • 财政年份：
    2020
  • 负责人：
    TERISA DAVIS
  • 依托单位：
    WESTAT, INC.
SCIENTIFIC SUPPORT SERVICES FOR THE NATIONAL CANCER INSTITUTE, DIVISIOIN OF CANCER CONTROL AND POPULATION SCIENCES (DCCPS)
  • 批准号：
    10671441
  • 项目类别：
  • 资助金额：
    $269.22万
  • 财政年份：
    2020
  • 负责人：
    TERISA DAVIS
  • 依托单位：
    WESTAT, INC.
Scientific Support Services for the National Cancer Institute, Division of Cancer Control and Population Sciences (DCCPS). POP 7/27/2019 - 7/26/2020.
  • 批准号：
    10039262
  • 项目类别：
  • 资助金额：
    $280.6万
  • 财政年份：
    2019
  • 负责人：
    TERISA DAVIS
  • 依托单位：
    WESTAT, INC.
海外基金