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A Randomized Phase II Trial of Low Dose Aspirin versus Placebo in High-Risk Indiv

A Randomized Phase II Trial of Low Dose Aspirin versus Placebo in High-Risk Indiv
低剂量阿司匹林与安慰剂在高危个体中的随机 II 期试验
批准号：
8762957
负责人：
TERISA DAVIS
金额：
$109.44万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-09-20 至 2016-09-19
来源：
https://reporter.nih.gov/project-details/8762957
关键词：
AddressAffectAspirinC-reactive proteinClinical TrialsCotinineDoseEuropeanGoalsInstitutesItalyLesionLeukotriene E4LeukotrienesLung AdenocarcinomaLung noduleMalignant neoplasm of lungMicroRNAsMonitorNodulePatientsPhasePhase II Clinical TrialsPlacebosPreventionProstaglandinsRandomizedSerumSmokerSolidSpiral Computed Tomographycohortdensitydouble-blind placebo controlled trialhigh riskoncologyscreeningurinary

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英文摘要
The proposed clinical trial shall address whether aspirin has utility in the prevention of lung adenocarcinoma. It is a phase IIb randomized placebo controlled, double blind trial of aspirin 100 mg per day given for 1 year to current and former smokers participating in helical CT screening trials at the European Institute of Oncology in Milan, Italy. The goal is to determine if low dose aspirin affects the size of non-solid or partially solid persistent lung nodules identified by CT, since a subset of these nodules represent precursors to lung cancer. The clinical trial shall be performed at the European Institute of Oncology, with monitoring and oversight provided by MD Anderson.
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