Remodeling potential of the mitral valve following surgical repair

手术修复后二尖瓣的重塑潜力

• 批准号: 8560669
• 负责人: JOSEPH H GORMAN
• 金额: $ 130.74万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8560669
• 关键词: Address; Anabolism; Anterior; Anticoagulants; Area; Biological Sciences; Cardiac; Cardiomyopathies; Cell Density; Cell physiology; Collagen Fiber; Computer Simulation; Coupled; Data; Elements; Endocarditis; Engineering; Failure; Fiber; Height; Hemorrhage; Homeostasis; Human; In Vitro; Infarction; Laboratories; Lead; Link; Longitudinal Studies; Maps; Matrix Metalloproteinases; Measurement; Mechanics; Metabolism; Mitral Valve; Mitral Valve Insufficiency; Modeling; Normal tissue morphology; Operative Surgical Procedures; Organ; Organism; Patients; Phase; Positioning Attribute; Property; Protein Biosynthesis; Recurrence; Research; Resolution; Shapes; Sheep; Stress; Stretching; Structure; Surgeon; Surgical sutures; Tachycardia; Techniques; Thromboembolism; Tissues; Torsion; Ultrasonography; Variant; Ventricular; Ventricular Remodeling; base; design; experience; heart valve replacement; improved; in vivo; interest; interstitial cell; novel; papillary muscle; programs; public health relevance; repaired; response; restoration; sound; tool; validation studies

DESCRIPTION (provided by applicant): After two decades of emphasis on valve replacement, cardiac surgeons have been gradually turning to mitral valve repair. MV repair, rather than replacement, maintains better ventricular mechanics and fewer complications, such as endocarditis, thromboembolism, and anticoagulant-related hemorrhage. Unfortunately, recent long term studies using more rigorous definitions of failure have identified less optimistic result for repair durability; bringing into question such aggressive surgical practice and suggesting that repair techniques though mature can be improved upon. In most cases, failures were a result of disruption at the leaflet, chordal, or annular suture lines. These failure modes suggest excessive tissue stress and the resulting strain induced tissue damage as an etiologic factor. Thus, there has been growing interest in developing more robust repair strategies for patients with IMR. Promising concepts include leaflet augmentation to restore leaflet mobility, and saddle shaped annuloplasty to restore normal annular shape. If designed correctly, leaflet augmentation techniques can alleviate chordal-leaflet tethering and reduce leaflet stress by promoting leaflet curvature and coaptation. Leaflet augmentation will also allow the placement of larger annuloplasty rings that should reduce annular-annuloplasty ring separation forces. We thus hypothesize that IMR repair techniques that reinstate normal annular geometry (size and shape) and restore mobile leaflet tissue will result in reduced annular and chordal force distribution compared with undersized flat annuloplasty alone. This in turn will lead to restoration of homeostatic normal tissue stress levels and MVIC biosynthetic responses, ultimately leading to improved repair durability.

描述（由申请人提供）：经过二十年对瓣膜置换术的重视，心脏外科医生逐渐转向二尖瓣修复。中压修复，而不是置换，可以维持更好的心室力学和更少的并发症，如心内膜炎、血栓栓塞和抗凝相关出血。不幸的是，最近使用更严格的故障定义的长期研究已经确定了不太乐观的修复耐久性结果；对这种侵略性的手术提出质疑，并暗示