Role of Beta-catenin in Epithelial Repair in Acute Lung Injury

β-连环蛋白在急性肺损伤上皮修复中的作用

• 批准号: 8496866
• 负责人: Rachel Lynne Zemans
• 金额: $ 12.52万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496866
• 关键词: Acute Lung Injury; Air Sacs; Alveolar; Area; Binding; Cadherins; Cell Death; Cell Line; Clinical; Complication; Critical Illness; Data; Disease; E-Cadherin; Elastases; Epithelial; Epithelial Cells; Epithelium; Expenditure; Gene Targeting; Genetic Transcription; Goals; Grant; Health Care Costs; In Vitro; Inflammatory; Injury; Leukocyte Elastase; Lung; Mechanical ventilation; Mediating; Membrane; Modeling; Morbidity - disease rate; Mus; Pathway interactions; Patients; Peptide Hydrolases; Permeability; Phase; Play; Population; Proliferating; Proteins; Recovery; Research; Research Personnel; Role; Severities; Signal Pathway; Signal Transduction; Speed; Supportive care; Tight Junctions; alveolar epithelium; alveolar type II cell; antimicrobial; beta catenin; design; injured; lung repair; mortality; neutrophil; novel therapeutics; public health relevance; receptor; repaired; response

DESCRIPTION (provided by applicant): This grant seeks to investigate the mechanisms by which PMN interactions with epithelial cells during transmigration activate 2-catenin-dependent signaling pathways in lung epithelial cells and the importance of these pathways in epithelial repair. We will determine the signaling pathways that trigger epithelial 2-catenin activation including E-cadherin cleavage by PMN elastase. We will determine the mechanisms by which 2- catenin activation promotes repair of epithelial injury induced by PMN transmigration in vitro and in murine models of ALI using gene-targeted mice.

描述（由申请人提供）：该赠款旨在研究肺部上皮细胞中PMN与上皮细胞相互作用与上皮细胞相互作用的机制，以及这些途径在上皮修复中的重要性。我们将确定触发上皮2-catenin激活的信号通路，包括PMN弹性酶的E-钙粘蛋白裂解。我们将确定2- catenin激活促进PMN透射在体外诱导的上皮损伤的机制，并使用靶向基因的小鼠在ALI的鼠模型中诱导的上皮损伤。