Harvard Regional Clinical Center of the NHLBI Heart Failure Network
NHLBI 心力衰竭网络哈佛区域临床中心
基本信息
- 批准号:8403728
- 负责人:
- 金额:$ 49.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdmission activityAncillary StudyBasic ScienceCardiacCardiopulmonaryCaringCessation of lifeClinicalClinical InvestigatorClinical ResearchClinical TrialsCollaborationsConsensusDataDatabasesDevelopmentDilated CardiomyopathyEducational CurriculumEnrollmentExerciseFunctional disorderFundingFutureGeneral HospitalsGenesHandHealthHeart failureHemoglobinHospitalizationHospitalsIndividualInstructionIntravenousInvestigationIronIron-Regulatory ProteinsKidneyLaboratoriesLeadershipLeft Ventricular Ejection FractionLifeLinkMassachusettsMeasuresMedical centerMentorsMissionMutationNational Heart, Lung, and Blood InstituteOralOutcomeOxygenOxygen ConsumptionPathologicPatient RecruitmentsPatientsPatternPerformancePhysiologicalPlacebosPlasmaPopulationPopulation HeterogeneityPrincipal InvestigatorProtocols documentationQuality of lifeResearchResearch DesignResearch PersonnelRoleScienceSiteSkeletal MuscleSystemTechniquesTestingTherapeuticTimeTrainingTraining SupportTranslatingVentricular FunctionWomanWorkarmcomparative effectivenesscytokinedesignethnic minority populationexperiencehepcidinimprovedindexingiron deficiencymembermetabolomicsnext generationnovelpreventprogramsrandomized trialrapid growthresponseskillstreatment strategyuptake
项目摘要
The Harvard Regional Clinical Center (RCC) ofthe current NHLBi Heart Failure (HF) Network, including a
Clinical Research Skills Development Core, looks fonA/ard to expanding into a triangle where 3 uniquely
aligned and supported HF programs will accelerate the mission ofthe NHBLI to improve the future for HF
patients. Study patient recruitment within this RCC will be enhanced through utilization of real-time
databases and diversity of site populations. Creation of new Network Assets is planned, using common data
fields that will bridge individual Network trials to multiply the scientific yield ofthe Network. These Assets will
inform current challenges in HF care, such as preventing hospitalizations, identifying new pathologic
mutations in dilated cardiomyopathy, and characterizing patients with improved LVEF. The Harvard RCC will
provide collaborative leadership for design and implementation of studies that address vital mechanistic and
therapeutic questions that cannot be answered without NHLBI sponsorship. One example is a 3-arm
comparative effectiveness study to determine Iron Repletion Effects on Exercise Capacity and Cardiac
Function in Heart Failure (IRONOUT HF). This study will add to the understanding ofthe physiologic impact
and explore treatments of iron deficiency in HF. The primary endpoint will be change in peak oxygen
consumption after 24 weeks of intravenous iron, oral iron, or placebo. If benefit is shown, oral iron will be
assessed for non-inferiority compared to the more expensive and inconvenient therapy with intravenous
iron. This study will also assess skeletal muscle oxygen utilization during low level exercise, and relate
changes in hemoglobin, iron stores, the iron-regulatory protein hepcidin, and novel iron-dependent
metabolomic profiles to changes in exercise capacity in order to identify patients most likely to benefit from
iron repletion. The Clinical Research Skills Development Core supports a rigorous course curriculum,
hands-on-laboratory experience, and a Mentor Review Board to train and inspire new HF clinical
investigators. Utilizing the Network Assets, an Apprentice Investigator Network is planned where fellows
throughout the HF Network will collaborate to become the next generation of clinical investigators.
RELEVANCE (See instructions):
Heart failure is a growing burden on US health that can only be diminished by the collaboration of leading
investigators through initiatives such as the NHLBI Heart Failure Network. The Harvard Regional Clinical
Center proposes to join other leaders in the field in studies such as IRONOUT HF, testing whether treatment
of iron deficiency in heart failure patients with either oral or intravenous iron will improve exercise capacity.
目前NHLBi心力衰竭(HF)网络的哈佛地区临床中心(RCC),包括一个
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MICHAEL M GIVERTZ其他文献
MICHAEL M GIVERTZ的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MICHAEL M GIVERTZ', 18)}}的其他基金
Harvard Regional Clinical Center of the NHLBI Heart Failure Network
NHLBI 心力衰竭网络哈佛区域临床中心
- 批准号:
8588996 - 财政年份:2012
- 资助金额:
$ 49.19万 - 项目类别:
Harvard Regional Clinical Center of the NHLBI Heart Failure Network
NHLBI 心力衰竭网络哈佛区域临床中心
- 批准号:
8198047 - 财政年份:2012
- 资助金额:
$ 49.19万 - 项目类别:
NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
人类心肌衰竭中的无应激和氧化应激
- 批准号:
6183194 - 财政年份:1999
- 资助金额:
$ 49.19万 - 项目类别:
NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
人类心肌衰竭中的无应激和氧化应激
- 批准号:
6659095 - 财政年份:1999
- 资助金额:
$ 49.19万 - 项目类别:
NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
人类心肌衰竭中的无应激和氧化应激
- 批准号:
2881615 - 财政年份:1999
- 资助金额:
$ 49.19万 - 项目类别:
NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
人类心肌衰竭中的无应激和氧化应激
- 批准号:
6388550 - 财政年份:1999
- 资助金额:
$ 49.19万 - 项目类别:
NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
人类心肌衰竭中的无应激和氧化应激
- 批准号:
6526729 - 财政年份:1999
- 资助金额:
$ 49.19万 - 项目类别:
NO AND OXIDATIVE STRESS IN HUMAN MYOCARDIAL FAILURE
人类心肌衰竭中的无应激和氧化应激
- 批准号:
6597004 - 财政年份:1999
- 资助金额:
$ 49.19万 - 项目类别: