Integrative Membrane Physiology in the Post-Genome Era
后基因组时代的综合膜生理学
基本信息
- 批准号:8399465
- 负责人:
- 金额:$ 0.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2013-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAnimal ModelAwardBasic ScienceBiologicalBudgetsCaliforniaCellsClinicalCollaborationsColoradoComplexCystic FibrosisDiseaseEnsureFemaleFosteringFundingGenderGenetic ModelsGenomeGenomicsGoalsGovernmentHealthHumanInternationalIon ChannelIon TransportIonsIowaLaboratoriesLeadMarinesMassachusettsMembraneMinorityModelingMolecularNationalitiesNatureParticipantPathogenesisPatientsPharmacologic SubstancePharmacologyPhysiologyPostdoctoral FellowProteomicsRecording of previous eventsResearchResearch PersonnelSan FranciscoScheduleScientistSeminalSenior ScientistSocietiesStagingStructureStudentsTranslatingTransmembrane TransportTravelUnited States National Academy of SciencesUniversitiesVariantWashingtonWood materialWorkabstractingcareerdesigndrug discoveryinduced pluripotent stem cellinnovationinsightmeetingsmembernovelnovel therapeuticspostersprogramsstructural biologysuccesssymposium
项目摘要
DESCRIPTION (provided by applicant): We request funds to support an international symposium entitled "Integrative Membrane Physiology in the Post-Genome Era" to be held September 5th-9th, 2012, at the Marine Biological Laboratory in Woods Hole, Massachusetts. This will be the 66th Annual Symposium of the Society of General Physiologists (SGP). The annual symposium of the SGP has a long-standing reputation as being one of the most pioneering, collegial, and high-impact meetings for physiologists, cell biologists and biophysicists spanning all career stages (including students, postdoctoral fellows/researchers, and junior and established investigators), professional arenas (including academic, government, private, and pharmaceutical) and nationalities. With typically less than 200 participants, SGP symposia are large enough to provide in-depth coverage of thematic topics and small enough to encourage small- group discussions and foster cross-disciplinary collaborations to tackle the increasingly complex problems in human health related to membrane transport. The budget is structured to facilitate these productive interactions by supporting an exceptional lineup of invited speakers, a diverse group of junior-, intermediate- and senior-level scientists, and a strong attendance of underrepresented and underprivileged researchers. A highly ambitious program comprising a veritable "who's who" in the ion transport field has been carefully developed for the SGP 2012 symposium. There will be two keynote addresses delivered by internationally recognized leaders in ion channel research: Dr. Michael Welsh (HHMI/University of Iowa) and Dr. Robert Kass (Columbia University). The program was developed by a distinguished Organizing Committee consisting of leaders in the membrane transport field, including J. Nerbonne (Washington University), L. Ptacek (University of California - San Francisco), A. Ribera (University of Colorado) and A. Verkman (University of California - San Francisco). The symposium will focus on 4 major themes: (1) Genomics and Ion Channelopathies, (2) Genetic Model Organisms, (3) Ion Channel Complexes, and (4) Drug Discovery. There will be two independent sessions on Drug Discovery, highlighting efforts to translate basic science discoveries into novel therapeutics for transport-related disease. The SGP and members of the Organizing Committee are poised to ensure the success of this meeting. The symposium will focus on the most exciting and timely discoveries in membrane transport physiology, with an overarching emphasis on translating this work into novel therapies.
PUBLIC HEALTH RELEVANCE: We request funds to support an international symposium entitled "Integrative Membrane Physiology in the Post-Genome Era" to be held September 5th-9th, 2012, at the Marine Biological Laboratory in Woods Hole, Massachusetts. This meeting will be the 66th Annual Symposium of the Society of General Physiologists (SGP). The annual symposium of the SGP has a long-standing history and reputation of being one of the most innovative meetings for membrane transport physiologists, cell biologists, and biophysicists worldwide that span across all career stages (including students, postdoctoral fellows, new investigators, as well as established and senior scientists) and professional arenas (including academic, government, private, and pharmaceutical).
描述(由申请人提供):我们要求资助一项名为“后基因组时代的整合膜生理学”的国际研讨会,该研讨会将于2012年9月5日至9日在马萨诸塞州伍兹霍尔海洋生物实验室举行。这将是第66届普通生理学家协会(SGP)年会。SGP年度研讨会长期以来一直享有盛誉,是生理学家,细胞生物学家和生物物理学家最具开创性,合议性和高影响力的会议之一,涵盖所有职业阶段(包括学生,博士后研究员/研究人员,初级和成熟的研究人员),专业领域(包括学术,政府,私人和制药)和国籍。SGP专题讨论会通常少于200人,其规模足够大,可以提供深入的专题报道,规模足够小,可以鼓励小组讨论,促进跨学科合作,以解决与膜运输有关的人类健康日益复杂的问题。预算的结构是为了促进这些富有成效的互动,通过支持一个特殊的受邀演讲者阵容,一个由初级、中级和高级科学家组成的多样化群体,以及一个代表性不足和弱势的研究人员的强大出席。为SGP 2012研讨会精心制定了一项雄心勃勃的计划,其中包括离子输运领域名副其实的“名人赛”。届时将有两位国际公认的离子通道研究领导者发表主题演讲:Michael Welsh博士(HHMI/ Iowa大学)和Robert Kass博士(哥伦比亚大学)。该计划由膜运输领域的杰出组织委员会开发,包括J. Nerbonne(华盛顿大学),L. Ptacek(加州大学旧金山分校),a . Ribera(科罗拉多大学)和a . Verkman(加州大学旧金山分校)。研讨会将集中讨论4个主要主题:(1)基因组学和离子通道病变;(2)遗传模式生物;(3)离子通道复合物;(4)药物发现。将有两场关于药物发现的独立会议,重点介绍将基础科学发现转化为运输相关疾病的新疗法的努力。SGP和组委会成员将确保本次会议取得成功。研讨会将集中讨论膜运输生理学中最令人兴奋和及时的发现,并重点介绍将这项工作转化为新的治疗方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jerod S. Denton其他文献
A LRRC8 chimera with native functional properties is a heptamer with a large lipid-blocked pore
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55: Rational Synthesis of a Selective Renal Outer Medullary Potassium Channel (ROMK) Antagonist
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2010-04-01 - 期刊:
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Gautam Bhave;Brian A. Chauder;Rishin Kadakia;Eric S. Dawson;Craig W. Lindsley;C. David Weaver;Jerod S. Denton - 通讯作者:
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Development of Small-Molecule Inhibitors of Proton-Activated Chloride Channels
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10.1016/j.bpj.2019.11.3197 - 发表时间:
2020-02-07 - 期刊:
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Eric E. Figueroa;Jerod S. Denton - 通讯作者:
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Oligomeric structure of LRRC8/VRAC channels: Arguments for a heptameric conformation
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10.1016/j.bpj.2022.11.789 - 发表时间:
2023-02-10 - 期刊:
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- 作者:
Jerod S. Denton;Toshiki Yamada;Hirohide Takahashi;Erkan Karakas;Kevin Strange - 通讯作者:
Kevin Strange
CysLT1 Receptor Antagonists Pranlukast and Zafirlukast Inhibit <em>LRRC8</em>-Mediated Volume Regulated Anion Channels Independently of the Receptor
- DOI:
10.1016/j.bpj.2019.11.3186 - 发表时间:
2020-02-07 - 期刊:
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Eric E. Figueroa;Jerod S. Denton - 通讯作者:
Jerod S. Denton
Jerod S. Denton的其他文献
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{{ truncateString('Jerod S. Denton', 18)}}的其他基金
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- 批准号:
10437919 - 财政年份:2020
- 资助金额:
$ 0.85万 - 项目类别:
Pharmacological Validation of Vascular KATP Channels for Modulating Ductus Arteriosus Tone
调节动脉导管张力的血管 KATP 通道的药理学验证
- 批准号:
10247076 - 财政年份:2020
- 资助金额:
$ 0.85万 - 项目类别:
Pharmacological Validation of Vascular KATP Channels for Modulating Ductus Arteriosus Tone
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- 批准号:
10053976 - 财政年份:2020
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Developing modulators of the sperm-specific potassium channel SLO3 for contraception
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10018521 - 财政年份:2019
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Development of Distal Nephron Diuretics Targeting Kir4.1/5.1 Heteromeric Potassium Channels
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- 批准号:
10179370 - 财政年份:2019
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$ 0.85万 - 项目类别:
Developing modulators of the sperm-specific potassium channel SLO3 for contraception
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- 批准号:
10470966 - 财政年份:2019
- 资助金额:
$ 0.85万 - 项目类别:
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$ 0.85万 - 项目类别:
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