Emory Epithelial Pathobiology Research Development Center

埃默里大学上皮病理学研究发展中心

• 批准号: 8288323
• 负责人: CHARLES A PARKOS
• 金额: $ 50.38万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-23 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8288323
• 关键词: Advisory Committees; Annexins; Apoptosis; Apoptotic; Area; Biology; CCR6 gene; Categories; Cell Culture Techniques; Cell Proliferation; Childhood; Clinical Nutrition; Colitis; Collaborations; Communicable Diseases; Coupled; Critical Care; Development; Diabetes Mellitus; Diarrhea; Digestive System Disorders; Direct Costs; Endocrinology; Epithelial; Epithelial Cells; Epithelium; Financial Support; Flagellin; Fostering; Functional disorder; Funding; Future; GTP-Binding Proteins; Gastrointestinal tract structure; Gene Expression; Goals; Gold; Graft Rejection; Grant; Helicobacter Infections; Hepatic Fibrogenesis; Hepatitis C; Host Defense; Image Analysis; Individual; Infection; Inflammation; Inflammatory disease of the intestine; Institution; Intention; Intestines; Journals; Kidney; Liver; Lung; Lymphocyte; MMP9 gene; Medicine; Mission; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Neurofibromin 2; Newsletter; Nox enzyme; Operative Surgical Procedures; Oxidation-Reduction; Oxidative Stress; Parkinsonian Disorders; Pathology; Pediatric Neurology; Peer Review; Physiological Processes; Physiology; Play; Productivity; Program Research Project Grants; Publishing; Purinergic P1 Receptors; Regulation; Research; Research Personnel; Research Support; Rodent; Role; Schools; Series; Services; Short Bowel Syndrome; Signal Transduction; Sodium; Structure; Structure of thyroid parafollicular cell; TLR5 gene; Telomerase; Tight Junctions; Ubiquitination; Universities; Urea; Work; Wound Healing; Yang; Zebrafish; base; cell motility; college; cost; falls; gastrointestinal system; glucagon-like peptide 1; immunoregulation; interest; medical schools; meetings; member; migration; neutrophil; non-alcoholic fatty liver; nutrition; programs; research and development; response; symposium; tumorigenesis; wound

The Emory Epithelial Pathobiology Research Development Center was established in June of 2003 as one of four newly funded Digestive Diseases Research Development Centers (DDRDCs) supported by the NIDDK. The goal of the Center is to provide core services to a group of highly specialized and interactive epithelial biologists and pathobiologists in the digestive system with the intention of enhancing research capability, promoting new research directions, and fostering collaboration and interaction among the investigators. Research supported by the Center is mainly focused on epithelial biology and pathobiology of the digestive tract with three overarching themes: Inflammation/Infection, Proliferation/ Differentiation, and Normal Physiology. The Center has three cores: (A) Gene Expression Analysis Core, (B) Image Analysis Core, and (C) Cell Culture Core. In the past few years, these cores have played crucial roles in the development of a digestive diseases-centered research program at Emory and significantly enhanced the research capability of Center members as demonstrated by their outstanding scientific productivity. At its inception, the Center had 9 established investigators (full members) and 5 junior investigators (junior members) with a combined annual direct costs of $2,965,972 (55% of which supported by NIDDK). To date, the Center has evolved into a group of 21 full members and 8 junior members spanning across Departments of Medicine (including Divisions of Digestive Diseases, Endocrinology, Nephrology, Pulmonary & Critical Care Medicine, and Infectious Diseases), Pathology, Physiology, Surgery, Pediatrics, and Neurology in the Emory University School of Medicine, and Department of Biology in the Emory College. The combined annual director costs of this competing renewal application are $8,862,960, 67.7% of which are funded by the NIDDK. Thus, in less than 4 years, the Center has more than doubled its membership and nearly tripled its base grant support. Importantly, since 2003, this group of investigators collectively published 441 original research articles in peer-reviewed journals, out of which 100 contained 2 or more authors that are members of the Center. Moreover, at least 124 of these published work used core services provided by the Center, the majority of which cited the contribution of the Center. The Center has also received substantial amounts of financial support from the institution (Office of the Dean, Chairs of Medicine and Pathology, and Division of Digestive Diseases) with which to implement a highly successful enrichment program including a Pilot/Feasibility Project Grant Program, Research Seminar Series, Annual Scientific Symposium and Advisory Committee Meeting, and periodic Newsletters. The continuation of the Center will therefore further increase the strength of digestive diseases research at Emory with a strong focus on areas within the missions supported by the NIDDK.

埃默里上皮病理生物学研究发展中心成立于2003年6月，是NIDDK支持的四个新资助的消化疾病研究发展中心之一。该中心的目标是为一群高度专业化和互动的消化系统上皮生物学家和病理生物学家提供核心服务，旨在提高研究能力，促进新的研究方向，并促进研究人员之间的合作和互动。该中心支持的研究主要集中在消化道的上皮生物学和病理生物学上，主要有三个主题：炎症/感染、增殖/分化和正常生理。该中心有三个核心：(A)基因表达分析核心，(B)图像分析核心，(C)细胞培养核心。在过去的几年里，这些核心在埃默里以消化疾病为中心的研究计划的发展中发挥了关键作用，并显著增强了中心成员的研究能力，其杰出的科学生产力证明了这一点。在成立之初，该中心有9名常设调查员(正式成员)和5名初级调查员(初级成员)，每年的直接费用合计为2965,972美元(其中55%由NIDDK资助)。到目前为止，该中心已发展成为一个由21名正式成员和8名初级成员组成的小组，横跨埃默里大学医学院的内科(包括消化科、内分泌科、肾脏科、肺科和重症监护内科和传染病科)、病理学、生理学、外科、儿科和神经科以及埃默里学院的生物系。这一竞争性续签申请的年度总董事费用为8,862,960美元，其中67.7%由NIDDK提供资金。因此，在不到4年的时间里，该中心的成员增加了一倍多，基本赠款支持增加了近两倍。重要的是，自2003年以来，这组调查人员总共在同行评议的期刊上发表了441篇原创研究论文，其中100篇包含2名或2名以上的中心成员作者。此外，在这些已发表的著作中，至少有124部使用了该中心提供的核心服务，其中大部分引用了该中心的贡献。该中心还得到了该机构(院长办公室、医学和病理主任以及消化科)的大量财政支持，用于实施一项非常成功的丰富计划，包括试点/可行性项目资助计划、研究研讨会系列、年度科学研讨会和咨询委员会会议以及定期通讯。因此，该中心的继续存在将进一步加强埃默里大学消化疾病研究的力量，重点放在NIDDK支持的特派团内的领域。

项目成果

MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.

• DOI: 10.1053/j.gastro.2010.11.054
• 发表时间: 2011-03
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Lee SJ;Ritter SL;Zhang H;Shim H;Hall RA;Yun CC
• 通讯作者: Yun CC

Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis.

• DOI: 10.1371/journal.pone.0003304
• 发表时间: 2008-10-01
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chandrasekharan B;Bala V;Kolachala VL;Vijay-Kumar M;Jones D;Gewirtz AT;Sitaraman SV;Srinivasan S
• 通讯作者: Srinivasan S

Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion.

• DOI: 10.1085/jgp.200910339
• 发表时间: 2010-01
• 期刊: The Journal of general physiology
• 作者: Hoque KM;Woodward OM;van Rossum DB;Zachos NC;Chen L;Leung GP;Guggino WB;Guggino SE;Tse CM
• 通讯作者: Tse CM

Antigen sampling by intestinal M cells is the principal pathway initiating mucosal IgA production to commensal enteric bacteria.

• DOI: 10.1038/mi.2015.121
• 发表时间: 2016-07
• 期刊: Mucosal immunology
• 影响因子: 8
• 作者: Rios D;Wood MB;Li J;Chassaing B;Gewirtz AT;Williams IR
• 通讯作者: Williams IR

Blockade of adenosine A2B receptors ameliorates murine colitis.

腺苷A2B受体的阻断可改善鼠类结肠炎。

• DOI: 10.1038/bjp.2008.227
• 发表时间: 2008-09
• 期刊: BRITISH JOURNAL OF PHARMACOLOGY
• 影响因子: 7.3
• 作者: Kolachala, V. L.;Ruble, B. K.;Vijay-Kumar, M.;Wang, L.;Mwangi, S.;Figler, H. E.;Figler, R. A.;Srinivasan, S.;Gewirtz, A. T.;Linden, J.;Merlin, D.;Sitaraman, S. V.
• 通讯作者: Sitaraman, S. V.