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Phase sequences of posterior parietal cortex ensembles and sequence learning

后顶叶皮层集合的相序列和序列学习

基本信息

批准号：
8842304
负责人：
Aaron A Wilber
金额：
$ 5.1万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-01 至 2015-04-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8842304
关键词：
Phase sequences posterior parietal cortex

项目摘要

DESCRIPTION (provided by applicant): Learning sequences is part of our daily lives, from getting dressed to remembering the event sequence of our day. Humans and other animals who develop mental disorders both have problems with many types of sequence learning. The objective of the proposed research is to understand how spatial sequences are learned and encoded by brain circuits so future experiments can measure deficits in brain coding of sequences that may underlie mental disorders. Currently, an animal model of how the normal brain accomplishes sequence learning does not exist and is necessary for understanding what goes wrong to produce deficits. Our laboratory has made progress towards developing a model of sequence learning by recording simultaneously from many neurons in the brain while rats learn to navigate to a series of spatial locations arranged around a circular arena. This task has allowed us to begin to understand how part of the brain, the hippocampus, encodes where the animal is in this spatial sequence; however, we do not yet know how the brain translates this information about position in the sequence into a motor response to navigate to the next reward location. Previous research suggests that the parietal cortex may translate an appropriate motor response for the current position in the sequence. Therefore, I will investigate the brain mechanism for translating information about position in a sequence to an appropriate motor response. In three different experiments, I will assess: a) the frames of reference (person centered vs world centered) that are used when spatial cues are encoded in the parietal cortex; b) activity patterns in the parietal cortex during sequence learning; c) contributions of the parietal cortex to encoding learned sequences (specifically, what happens when the parietal cortex is inhibited during particular portions of spatial sequence learning and memory). These initial experiments will provide a foundation for the neural basis of sequence learning so that we can assess deficits in brain coding of sequences that may underlie psychiatric disorders.

描述（由申请人提供）：学习序列是我们日常生活的一部分，从穿衣服到记住我们一天的事件序列。人类和其他患有精神疾病的动物都有许多类型的序列学习问题。这项研究的目的是了解空间序列是如何被大脑回路学习和编码的，以便未来的实验可以测量大脑编码序列的缺陷，这些序列可能是精神障碍的基础。目前，正常大脑如何完成序列学习的动物模型还不存在，并且对于理解什么出错产生缺陷是必要的。我们的实验室已经在开发序列学习模型方面取得了进展，通过同时记录大脑中许多神经元的信息，同时大鼠学习导航到一系列围绕圆形竞技场排列的空间位置。这个任务让我们开始了解大脑的一部分，海马体，是如何编码动物在这个空间序列中的位置的;然而，我们还不知道大脑如何将这个关于序列中位置的信息转化为运动反应，以导航到下一个奖励位置。先前的研究表明，顶叶皮层可能会为序列中的当前位置翻译适当的运动反应。因此，我将研究将序列中的位置信息转化为适当运动反应的大脑机制。在三个不同的实验中，我将评估：a）参考框架（以人为中心对以世界为中心），当空间线索在顶叶皮层中编码时使用; B）在序列学习期间顶叶皮层中的活动模式; c）顶叶皮层对编码学习序列的贡献（特别是，当顶叶皮层在空间序列学习和记忆的特定部分受到抑制时会发生什么）。这些初步的实验将为序列学习的神经基础提供基础，这样我们就可以评估大脑编码序列的缺陷，这些缺陷可能是精神疾病的基础。