Research Training in Oncology

描述（由申请人提供）：这是Tufts医学中心William Dameshek血液学/肿瘤学部门的一份修订申请，申请竞争性更新我们长期的培训资助，T32 CA09429，题为“肿瘤学研究培训”。申请的长期目标没有改变，即继续培训和指导血液学/肿瘤学部门奖学金计划的医生在基础和转化癌症科学方面，以便为他们在血液学/肿瘤学学术领域的独立职业生涯做好准备。该计划基于塔夫茨医学中心（塔夫茨MC）的血液/肿瘤学部门，塔夫茨大学医学院（TUSM）的主要教学医院。培训计划是一个高度结构化的研究经验，以教师导师的研究小组的实验室调查为中心。正式的课程、其他教学训练以及参加研讨会、讲习班和会议是对实验室部分的补充。每个学员的进步都由一个研究委员会密切监视。该项目目前有26名研究教师导师，他们来自塔夫茨医学中心和塔斯马尼亚大学其他临床和基础科学部门的成员，比2002年竞争更新时的19名项目教师有了显著增加。这反映了Tufts MC和TUSM在战略计划中对癌症的新的重视，导致了分子肿瘤研究所的建立，以及Tufts医学中心癌症中心获得国家癌症研究所综合癌症中心指定的重大机构努力。该项目的教师导师代表了申请的主要优势，他们是根据他们的培训记录和他们在肿瘤的特定研究兴趣精心挑选的，这些兴趣涵盖了癌基因和肿瘤抑制因子，信号转导，细胞周期调节和凋亡，血管生成和转移，血液恶性肿瘤和实体肿瘤的动物模型，以及分子靶向癌症治疗的临床前测试。这个培训项目非常成功地为我们的研究员在肿瘤学学术领域的职业生涯做好了准备。以前的学员现在领导着学术界的主要部门和NCI指定的癌症中心，在美国和其他地方的学术机构担任教职，并在肿瘤制药领域担任高级管理职位。

DESCRIPTION (provided by applicant): This is a revised application from the William Dameshek Division of Hematology/Oncology at Tufts Medical Center for competitive renewal of our long-standing training grant, T32 CA09429, entitled "Research Training in Oncology". The long-term objective of the application has not changed, which is to continue the training and mentoring of physicians in the Hematology/Oncology Division Fellowship Program in basic and translational cancer science, in order to prepare them for independent careers in academic hematology/oncology. The program is based in the Division of Hematology/Oncology at Tufts Medical Center (Tufts MC), the principal teaching hospital for Tufts University School of Medicine (TUSM). The training program is a highly structured research experience that is centered around laboratory investigation within the research group of a faculty mentor. The laboratory component is complimented by formal coursework, other didactic training, and participation in seminars, workshops, and meetings. The progress of each trainee is closely monitored by a research committee. The Program currently has 26 research faculty mentors drawn from members of the Division and from other clinical and basic science departments at Tufts MC and TUSM, a significant increase from 19 Program faculty in the last competitive renewal in 2002. This reflects a new emphasis on cancer in the strategic plans of Tufts MC and TUSM, leading to the establishment of the Molecular Oncology Research Institute, and a major institutional effort to obtain National Cancer Institute Comprehensive Cancer Center designation for the Tufts Medical Center Cancer Center. The Program faculty mentors represent a major strength of the application, and are carefully selected on the basis of their training record and for their specific research interests in neoplasia, which span the spectrum from oncogenes and tumor suppressors, signal transduction, cell cycle regulation and apoptosis, angiogenesis and metastasis, animal models of hematologic malignancies and solid tumors, and preclinical testing of molecularly targeted cancer therapeutics. This training Program has been highly successful in preparing our fellows for careers in academic oncology. Former trainees now head major departments in academia and in NCI designated cancer centers, are on faculty at academic institutions in the US and elsewhere, and hold senior management positions in the oncology pharmaceutical field. RELEVANCE: The treatment of cancer has been revolutionized over the past ten years through the development of drugs that specifically target cancer cells. The United States has a great need for cancer doctors who work at the interface between cancer patients and experimental treatments, and who can discover and apply the next generation of therapies. This grant application will support the training of such physicians at Tufts Medical Center, continuing a program that has generated leaders in this field for more than a quarter century.