UC Davis Multi-Disciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America.

加州大学戴维斯分校多学科癌症研究培训计划，以推进拉丁美洲的精准癌症预防和护理。

• 批准号: 10438437
• 负责人: Luis Guillermo Carvajal Carmona
• 金额: $ 27万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10438437
• 关键词: Address; Age; American; Area; Basic Science; Bioinformatics; Cancer Burden; Cancer Center; Cancer Control; Cessation of life; Clinical; Clinical Oncology; Collaborations; Colombia; Colombian; Complement; Country; Demography; Development; Educational Curriculum; Ethics; European; Foundations; Funding; Funding Opportunities; Goals; Healthcare; Home; Individual; Infection Control; Institution; Knowledge; Latin America; Latin American; Latino Population; Lead; Life Expectancy; Malignant Neoplasms; Mentors; Mutation; National Cancer Institute; Oncology; Patients; Peru; Peruvian; Physicians; Population; Precision therapeutics; Principal Investigator; Provider; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resource Development; Resources; Risk Assessment; Solid; Training; Training Programs; United States National Institutes of Health; Universities; anticancer research; base; biobank; cancer care; cancer epidemiology; cancer genetics; cancer risk; cancer therapy; cloud based; experience; graduate student; health care availability; human capital; individualized prevention; low and middle-income countries; multidisciplinary; pre-clinical; precision cancer prevention; precision oncology; programs; skills; tool

PROJECT SUMMARY Improvements in health care access and infection control have led to life expectancy increases in Low- and Middle-Income Countries (LMICs) in Latin America. As the population ages, the Latin American cancer burden has dramatically increased. By 2030, Latin America is expected to have annual averages of 1.6M new cancer cases and 1M cancer deaths. A Latin America Lancet Oncology Commission report highlighted the small amount of preclinical and clinical oncology research originating in the region as a limitation to control cancer burden. Colombia and Peru, the Latin American LMICs with the first and second largest populations, have state-funded national cancer institutes (NCIs) that are cancer treatment reference centers, and which lead national efforts in cancer control and care. However, cancer risk assessment and patient treatment at these institutions is primarily based on tools developed in North American and European patients. Despite having exceptional researchers and physicians, most cancer centers in Latin America lack training programs that would allow them to develop or adapt precision prevention or treatment tools that are appropriate to the ancestry or mutation profiles of individuals from the region. The current funding opportunity is the ideal program to formalize and enhance ongoing collaborations between US-based healthcare researchers and providers in Colombia and Peru. It will provide a solid foundation for precision oncology research knowledge transfer and to build local human capital necessary to develop precision cancer medicine in Latin America. Building on our extensive expertise on Latin American population demography, cancer epidemiology and genetics, NIH funded cancer studies in Latino populations, and a strong track record of research collaboration and training with Colombian and Peruvian researchers, the overall goals of the UC Davis Multidisciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America are to: 1) Enhance local capacity for precision cancer medicine research in Colombia and Peru by implementing a curriculum that complements and addresses gaps in local training programs and provides hands on experience and support for research project development relevant to the region, 2) Provide hands on training on research resource development including ethics training, biobanking best practices, and cloud-based bioinformatics; and 3) allocate pilot funding for mentored research for basic science and clinically-oriented term trainees. We propose to establish a curriculum to train graduate students and postdoctoral/clinical fellows in precision oncology research. We will prepare trainees to implement and share their new skills in their home countries and to collaborate with U.S-based investigators. We will leverage ongoing collaborations among the program Principal Investigators, universities, and NCIs of Colombia and Peru to identify relevant areas of research that could be enhanced by the training program.

项目摘要 保健服务和感染控制的改善导致低收入和低收入人口的预期寿命增加， 拉丁美洲的中等收入国家（LMICs）。随着人口老龄化，拉丁美洲的癌症负担 急剧增加。到2030年，拉丁美洲预计每年平均有160万新癌症 例和100万例癌症死亡。拉丁美洲柳叶刀肿瘤学委员会的一份报告强调， 该地区的临床前和临床肿瘤学研究数量限制了癌症控制 负担哥伦比亚和秘鲁是拉丁美洲人口第一和第二多的中低收入国家， 国家资助的国家癌症研究所（NCI）是癌症治疗参考中心， 国家在癌症控制和护理方面的努力。然而，癌症风险评估和患者治疗在这些 研究机构主要基于北美和欧洲患者开发的工具。尽管 然而，拉丁美洲的大多数癌症中心缺乏培训计划， 将使他们能够开发或调整适合于他们的精确预防或治疗工具， 来自该地区的个人的祖先或突变概况。目前的融资机会是理想的 该计划旨在正式化和加强美国医疗保健研究人员之间的持续合作， 哥伦比亚和秘鲁的供应商。它将为精确的肿瘤学研究知识提供坚实的基础 转移和建立必要的当地人力资本，以在拉丁美洲发展精准癌症医学。 基于我们在拉丁美洲人口统计学、癌症流行病学和 遗传学，美国国立卫生研究院资助的拉丁美洲人群的癌症研究，以及良好的研究合作记录 与哥伦比亚和秘鲁的研究人员培训，加州大学戴维斯分校多学科的总体目标 癌症研究培训计划，以促进拉丁美洲的精确癌症预防和护理是： 1)在哥伦比亚和秘鲁，通过实施一项 补充和解决当地培训计划中的差距并提供实践经验的课程 并支持与该地区有关的研究项目开发，2）提供研究方面的实践培训 资源开发，包括道德培训、生物库最佳实践和基于云的生物信息学;以及 3)为基础科学和面向临床的短期受训人员的指导研究分配试点资金。我们 建议建立一个课程，以培训研究生和博士后/临床研究员在精度 肿瘤学研究我们将帮助受训人员在本国实施和分享他们的新技能 并与美国的调查人员合作。我们将利用该计划之间正在进行的合作， 哥伦比亚和秘鲁的主要研究者、大学和国家信息中心，以确定 可以通过培训计划来提高。