AccuTemp Sensor: Radiometry based non-invasive continuous core body temperature m

AccuTemp 传感器：基于辐射测量的无创连续核心体温测量仪

• 批准号: 8454842
• 负责人: Douglas O Reudink
• 金额: $ 18.69万
• 依托单位: THERMIMAGE, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8454842
• 关键词: Adopted; Anesthesia procedures; Bladder; Body Temperature; Body measure procedure; Brain; Bypass; Caliber; Calibration; Cardiac Surgery procedures; Cataloging; Catalogs; Cellular Phone; Cerebrum; Clinical; Clinical Trials; Computer software; Critical Care; Critical Illness; Detection; Development; Devices; Drops; Emergency Situation; Esophageal; Exposure to; Feedback; Forehead; Frequencies; Goals; Government; Head; Heart; Hemorrhage; Hospitalization; Hour; Human; Infection; Institution; Institutional Review Boards; Intensive Care; Investigation; Kidney; Length; Liquid substance; Liver; Lung; Maintenance; Measurement; Measures; Methods; Modeling; Monitor; Morbidity - disease rate; Myocardial; Near Drowning; Operating Rooms; Operative Surgical Procedures; Oral; Organ; Organ Temperatures; Outcome; Patients; Performance; Phase; Physicians; Practice Guidelines; Preparation; Procedures; Process; Protocols documentation; Pulmonary artery structure; Quality of life; Radiometry; Reading; Recovery; Recovery Room; Regulation; Reporting; Risk; Scalp structure; Signal Transduction; Site; Solid; Spleen; Staging; Structure of jugular vein; Surgeon; Surgical Wound Infection; Surgical complication; System; Technology; Temperature; Testing; Time; Tissue Model; Tissues; Work; base; brain tissue; cost; cranium; follow-up; improved; meetings; microwave electromagnetic radiation; monitoring device; natural hypothermia; non-invasive monitor; non-invasive system; novel; patient safety; public health relevance; rectal; response; sensor; success

DESCRIPTION (provided by applicant): Accurate measurement of core body temperature during surgery as well as in critical care is imperative to a positive outcome and ongoing quality of life for patients. Core temperature management of patients during extended anesthesia such as cardio-pulmonary bypass (CPB) surgery is equally important, yet there is no accurate core body measurement device available to physicians, surgeons and staffs today. With success in kidney and bladder temperature detection and monitoring, Thermimage is now developing the AccuTemp" Sensor, a non-invasive microwave based system to accurately and rapidly measure the core brain temperature at 4-5 cm. This system consists of a 2.5 cm receiving microwave antenna that will be placed on the patient's forehead, and a specialized radiometer to amplify and process the antenna signal to determine the actual brain temperature. The device will detect the energy emitted from the brain at near cellular phone frequencies (800-2500MHz), with a sensitive receiver that can detect microwave signals that are only a billionth of a watt strong. Core temperature monitoring devices used today infer temperature, but lack accuracy and the ability to rapidly report core temperature changes. Solid organ temperature from the heart, liver, spleen, kidneys and brain are best when monitoring core temperature and among these, the best and most critical measurement for treatment decisions is the brain. There are numerous surrogates of core temperature including oral, rectal, bladder, esophageal, tympanic and nasopharyngeal measures. These measures may be approximately correct when body temperature is stable. However, all are inadequate to detect and report the temperature of the brain when it is stable, or rapidly changing, either of which may require an immediate response from the surgical team. The most accurate predictions of brain temperature today uses intravascular sensors in the pulmonary artery or jugular vein, but these are inconvenient and potentially harmful. Even sensors directly in the brain have shown that when hypothermia is induced and reversed rapidly, standard monitoring sites fail to reflect cerebral temperature. Accurate body temperature monitoring is being emphasized in new physician practice guidelines with some ties to performance including a 2% reimbursement penalty to anesthesiologists not meeting the standard after 2014. It is imperative that anesthesiologists, intensive care physicians, neonatologists, and emergency physicians monitor the core body temperature for best patient outcomes. Clearly there is a need for new measuring body core temperature that provides fast and accurate readings of the body's most sensitive tissue, the brain. Thermimage's development of the novel AccuTemp Sensor will safely and reliably monitor deep brain temperature non-invasively, assisting greatly in creating best outcomes for patients, physicians and institutions.

描述（由申请方提供）：在手术期间以及重症监护期间准确测量核心体温对于患者的积极结局和持续生活质量至关重要。在心肺转流（CPB）手术等延长麻醉期间，患者的核心温度管理同样重要，但目前医生、外科医生和工作人员还没有准确的核心体温测量设备。 随着肾脏和膀胱温度检测和监测的成功，Thermimage现在正在开发AccuTemp”传感器，这是一种基于微波的非侵入性系统，可以准确快速地测量4-5 cm处的核心大脑温度。该系统由一个2.5厘米的接收微波天线和一个专门的辐射计组成，该天线将放置在患者的前额上，该辐射计用于放大和处理天线信号，以确定实际的大脑温度。该设备将检测大脑在接近手机频率（800- 2500 MHz）下发出的能量，其灵敏的接收器可以检测到只有十亿分之一瓦强的微波信号。 现今使用的核心温度监测装置推断温度，但缺乏准确性和快速报告核心温度变化的能力。当监测核心温度时，来自心脏、肝脏、脾脏、肾脏和大脑的实体器官温度是最好的，其中，用于治疗决策的最佳和最关键的测量是大脑。有许多核心温度的替代物，包括口腔、直肠、膀胱、食管、鼓膜和鼻咽测量。当体温稳定时，这些措施可能近似正确。然而，所有这些都不足以检测和报告大脑稳定或快速变化时的温度，这两种情况都可能需要手术团队立即做出反应。目前，对大脑温度最准确的预测是使用肺动脉或颈静脉中的血管内传感器，但这些传感器既不方便，也有潜在的危害。即使是直接在大脑中的传感器也表明，当低温被诱导并迅速逆转时，标准监测部位无法反映大脑温度。 在新的医生实践指南中强调了准确的体温监测，并与绩效有一些联系，包括2014年后对不符合标准的麻醉师进行2%的报销处罚。麻醉师、重症监护医生、麻醉师和急诊医生必须监测核心体温，以获得最佳患者结局。 显然，需要一种新的测量身体核心温度的方法，可以快速准确地读取身体最敏感的组织--大脑。Thermimage开发的新型AccuTemp传感器将安全可靠地无创监测脑深部温度，极大地帮助患者、医生和机构创造最佳结果。

项目成果

Non-invasive measurement of brain temperature with microwave radiometry: demonstration in a head phantom and clinical case.

• DOI: 10.15274/nrj-2014-10001
• 发表时间: 2014-02
• 期刊: The neuroradiology journal
• 作者: Stauffer PR;Snow BW;Rodrigues DB;Salahi S;Oliveira TR;Reudink D;Maccarini PF
• 通讯作者: Maccarini PF