UDEL Subproject 3

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Making adaptive changes in behavior in response to environmental change is essential to survival and therefore is likely to be mediated by complex interactions within a network of distributed neural circuits. One brain region that has been implicated in behavioral flexibility is the medial prefrontal cortex (mPFC). Damage to this region causes impairments in executive function, planning, and working memory, which are all important components of behavioral flexibility. Recording studies have shown that single mPFC neurons show elevated firing rates during the delay period of tasks that require the retention of information over a temporal gap, such as delayed-match/nonmatch-to-sample, suggesting that mPFC neurons are involved in working memory. Other studies have shown that mPFC activity shows anticipatory increases in firing rate prior to the execution of a response, suggesting its role in planning imminent actions. The goal ofthe current proposal is to dissociate mPFC involvement in working memory from other functions by comparing the effects of mPFC lesions and the firing patterns of mPFC single neurons between two similar tasks: one that requires working memory and one that does not. Additionally, reversal of these tasks will reveal the role of the mPFC in behavioral flexibility. Finally, we will investigate the interaction between the hippocampus and mPFC by inactivating the hippocampus and concurrently recording mPFC single neurons during task acquisition, performance and reversal. The results will aid in developing a better understanding ofthe role of the mPFC in adaptive behavior, both alone and in conjunction with the hippocampus.