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Osteoporosis in HIV Infected Postmenopausal Women

Osteoporosis in HIV Infected Postmenopausal Women
感染艾滋病毒的绝经后妇女的骨质疏松症
批准号：
8494520
负责人：
Elizabeth J Shane
金额：
$67.75万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-01 至 2015-06-30
来源：
https://reporter.nih.gov/project-details/8494520
关键词：
AccountingAddressAdultAdverse effectsAffectAfrican AmericanAgeAgingAnti-Retroviral AgentsBiochemicalBiological AssayBiopsyBody mass indexBone DensityBone remodelingCD4 Lymphocyte CountCellular biologyCytochrome P450DataDeteriorationElderlyEnrollmentForearmFractureFundingGrantHIVHIV InfectionsHigh PrevalenceHip region structureHispanicsIncidenceLongitudinal StudiesMetabolismMineralsMinorityNew York CityNucleotidesOsteoblastsOsteoclastsOsteoporosisPeripheralPopulationPostmenopausePrevalenceProtease InhibitorPublic HealthRecruitment ActivityRegimenRequest for ProposalsResolutionReverse Transcriptase InhibitorsRiskRisk FactorsRitonavirSubgroupTechniquesTenofovir disoproxil fumarateTestingUnited StatesVertebral columnVitamin DVitamin D DeficiencyWomanantiretroviral therapybasebonebone cellbone healthbone lossbone massbone strengthbone turnovercase controlcohortefavirenzemtricitabinehigh riskimmune functionimprovedindexingnew technologynovelosteoporosis with pathological fracturepublic health relevanceskeletal

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DESCRIPTION (provided by applicant): Postmenopausal HIV+ women are at increased risk of fracture and vulnerable to adverse effects of D deficiency, HIV infection and ART-related bone loss on bone strength. The increasing prevalence of HIV-infection on older minority women and the aging of the HIV-infected population make it critical to elucidate the effects of HIV and its treatment on bone health.
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