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Osteoporosis in HIV Infected Postmenopausal Women

Osteoporosis in HIV Infected Postmenopausal Women
感染艾滋病毒的绝经后妇女的骨质疏松症
批准号：
8494520
负责人：
Elizabeth J Shane
金额：
$67.75万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-01 至 2015-06-30
来源：
https://reporter.nih.gov/project-details/8494520
关键词：
AccountingAddressAdultAdverse effectsAffectAfrican AmericanAgeAgingAnti-Retroviral AgentsBiochemicalBiological AssayBiopsyBody mass indexBone DensityBone remodelingCD4 Lymphocyte CountCellular biologyCytochrome P450DataDeteriorationElderlyEnrollmentForearmFractureFundingGrantHIVHIV InfectionsHigh PrevalenceHip region structureHispanicsIncidenceLongitudinal StudiesMetabolismMineralsMinorityNew York CityNucleotidesOsteoblastsOsteoclastsOsteoporosisPeripheralPopulationPostmenopausePrevalenceProtease InhibitorPublic HealthRecruitment ActivityRegimenRequest for ProposalsResolutionReverse Transcriptase InhibitorsRiskRisk FactorsRitonavirSubgroupTechniquesTenofovir disoproxil fumarateTestingUnited StatesVertebral columnVitamin DVitamin D DeficiencyWomanantiretroviral therapybasebonebone cellbone healthbone lossbone massbone strengthbone turnovercase controlcohortefavirenzemtricitabinehigh riskimmune functionimprovedindexingnew technologynovelosteoporosis with pathological fracturepublic health relevanceskeletal

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中文摘要
翻译
描述(由申请人提供)：绝经后的艾滋病毒妇女骨折的风险增加，容易受到D缺乏、艾滋病毒感染和与抗逆转录病毒治疗相关的骨丢失对骨骼强度的不利影响。老年少数族裔妇女感染艾滋病毒的比例越来越高，感染艾滋病毒的人口老龄化，因此必须阐明艾滋病毒及其治疗对骨骼健康的影响。
英文摘要
DESCRIPTION (provided by applicant): Postmenopausal HIV+ women are at increased risk of fracture and vulnerable to adverse effects of D deficiency, HIV infection and ART-related bone loss on bone strength. The increasing prevalence of HIV-infection on older minority women and the aging of the HIV-infected population make it critical to elucidate the effects of HIV and its treatment on bone health.
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Phase 2 Teriparatide for Tx of Idiopathic Osteoporosis in Premenopausal Women
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