Osteoporosis in HIV Infected Postmenopausal Women

感染艾滋病毒的绝经后妇女的骨质疏松症

• 批准号: 8494520
• 负责人: Elizabeth J Shane
• 金额: $ 67.75万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8494520
• 关键词: Accounting; Address; Adult; Adverse effects; Affect; African American; Age; Aging; Anti-Retroviral Agents; Biochemical; Biological Assay; Biopsy; Body mass index; Bone Density; Bone remodeling; CD4 Lymphocyte Count; Cellular biology; Cytochrome P450; Data; Deterioration; Elderly; Enrollment; Forearm; Fracture; Funding; Grant; HIV; HIV Infections; High Prevalence; Hip region structure; Hispanics; Incidence; Longitudinal Studies; Metabolism; Minerals; Minority; New York City; Nucleotides; Osteoblasts; Osteoclasts; Osteoporosis; Peripheral; Population; Postmenopause; Prevalence; Protease Inhibitor; Public Health; Recruitment Activity; Regimen; Request for Proposals; Resolution; Reverse Transcriptase Inhibitors; Risk; Risk Factors; Ritonavir; Subgroup; Techniques; Tenofovir disoproxil fumarate; Testing; United States; Vertebral column; Vitamin D; Vitamin D Deficiency; Woman; antiretroviral therapy; base; bone; bone cell; bone health; bone loss; bone mass; bone strength; bone turnover; case control; cohort; efavirenz; emtricitabine; high risk; immune function; improved; indexing; new technology; novel; osteoporosis with pathological fracture; public health relevance; skeletal

DESCRIPTION (provided by applicant): Postmenopausal HIV+ women are at increased risk of fracture and vulnerable to adverse effects of D deficiency, HIV infection and ART-related bone loss on bone strength. The increasing prevalence of HIV-infection on older minority women and the aging of the HIV-infected population make it critical to elucidate the effects of HIV and its treatment on bone health.

描述（由申请人提供）：绝经后HIV阳性妇女骨折的风险增加，容易受到D缺乏、HIV感染和art相关骨质流失对骨强度的不利影响。老年少数民族妇女中艾滋病毒感染率的上升和艾滋病毒感染人口的老龄化使得阐明艾滋病毒及其治疗对骨骼健康的影响至关重要。