Therapeutic Strategies for the Management of HCV/HIV co- infection

最近在治疗和监测艾滋病毒-1感染方面取得的进展大大减少了与艾滋病毒有关的疾病和死亡率；然而，对艾滋病毒感染者的管理已变得越来越复杂。我们正在进行的研究包括：(1)评估管理丙型肝炎病毒(丙型肝炎病毒)感染者的新治疗策略，以及(2)确定预测丙型肝炎病毒对现有治疗的反应的标志性宿主反应特征，并帮助开发更好的未来治疗方法。在过去的一年里，我们得以(1)进行了一项新的临床试验，使用非干扰素疗法治疗丙型肝炎病毒1型感染；(2)启动了一项用于治疗艾滋病毒/丙型肝炎病毒感染者的无干扰素和利巴韦林的临床试验；(3)启动了一项临床试验，以确定使用干扰素和利巴韦林的非干扰素疗法有助于丙型肝炎病毒清除的因素。

Recent advances in the treatment and monitoring of HIV-1 infection have substantially diminished HIV-associated illness and mortality; however the management of HIV-infected patients has become increasingly complex. We are conducting studies that: (1) evaluate novel therapeutic strategies in the management of hepatitis C virus (HCV)-infected individuals, and (2) identify the signature host response characteristics that predict HCV response to existing treatment and aid in developing better future therapies. This past year, we were able to (1) conduct a novel clinical trial to use interferon free therapy for treatment of HCV genotype 1 infection (2) initiate an interferon and ribavirin free clinical trial for the treatment of HCV in HIV/HCV infected subjects (3) initiate a clinical trial to determine the factors that contribute to HCV clearance using Interferon and ribavirin free therapy.