Derivation and validation of a cardiac risk index in liver transplantation
肝移植心脏风险指数的推导和验证
基本信息
- 批准号:8545595
- 负责人:
- 金额:$ 5.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-09-01 至 2014-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlgorithmsAwardCalibrationCardiacCardiovascular DiseasesCardiovascular ManifestationCardiovascular systemClinicalClinical DataClinical ManagementClinical ResearchClinical TrialsComorbidityConsensusDataData AnalysesData SourcesDatabasesDecision AnalysisDerivation procedureDevelopmentDiabetes MellitusDiscriminationDisease MarkerEvaluationEventEvidence Based MedicineExpert OpinionFellowshipFutureGoalsGuidelinesHealth Care CostsHealthcareHepatologyHyperlipidemiaHypertensionInstitutesInternal MedicineInvestigationK-Series Research Career ProgramsLifeLiver diseasesMedicalMedicineMentorshipMethodologyMissionModelingMorbidity - disease rateObesityOperative Surgical ProceduresOrgan DonorOrgan ProcurementsOrgan TransplantationOutcomeOutcomes ResearchOutcomes and Health Services ResearchPatientsPerformancePerioperativePeripheral ResistancePhysiologicalPreventive MedicineProceduresProcessPublic HealthRegistriesRelative (related person)Research Project GrantsResource AllocationResourcesRiskRisk AssessmentRisk FactorsSelection BiasStagingStatistical ModelsStratificationTransplant RecipientsTransplantationUniversitiesValidationbasecardiovascular disorder epidemiologycardiovascular disorder riskcardiovascular risk factorcareer developmentchronotropiccost effectivenessdata managementdesignhigh riskimprovedindexingliver transplantationmeetingsmembermortalitymultidisciplinarypatient populationskillsstatisticstool
项目摘要
DESCRIPTION (provided by applicant): The goal of this postdoctoral fellowship is to facilitate the candidate's development as a leader in transplantation outcomes research, with a focus on perioperative cardiovascular (CV) risk assessment. Building on her background in internal medicine, transplant hepatology, and clinical investigation, the candidate proposes to develop additional skills during the award period through (1) coursework designed to expand her methodological skills; (2) interaction with a multidisciplinary team of sponsors and collaborators,
including those in cardiovascular epidemiology, risk assessment, transplantation outcomes, and health services research; and (3) a supervised research project. The overall objective of this project is to define and optimize a preoperative cardiovascular risk assessment model for orthotopic liver transplant (OLT) candidates through two primary specific aims: (1) To determine if a national liver transplant-specific Cardiovascular Risk Index (NOLT-CRI) improves the predictive utility of the commonly used revised cardiac risk index (RCRI) by (1.1) determining the discrimination (C-statistic) and calibration (Hosmer-Lemeshow statistic) of the RCRI as a model of 30-day CV events using secondary data analysis of a national database; and (1.2) comparing the clinical performance of the NOLT-CRI to the RCRI in its ability to reclassify 30-day CV risk and to stratify 1- year survival across the continuum of predicted 30-day CV risk; (2) To determine whether additional variables are needed beyond those available within a national database in order to improve the predictive ability of these models by (2.1) determining the model discrimination and calibration of a locally-derived cardiac risk index (LOLT-CRI) using a center-specific database with more detailed clinical data than are currently available nationally; and (2.2) comparing the clinical performance of the LOLT-CRI to the national models in its ability to reclassify risk. This project will meet the mission of the National Institutes of Healthby identifying cardiovascular disease markers that are unique to the liver transplant candidate, which can then be used to improve pre- and post-transplant medical management in this growing patient population. The project, along with the chosen coursework and mentorship, will allow the candidate to become proficient at data management and statistical methodology. Near the end of the award period, the candidate plans to submit a career development award using the results of the project to develop a cardiovascular risk assessment treatment algorithm for use prior to liver transplantation.
描述(由申请人提供):该博士后奖学金的目标是促进候选人在移植结果研究方面的发展,重点是围手术期心血管(CV)风险评估。基于她在内科、移植肝病学和临床研究方面的背景,候选人建议在奖励期间通过以下课程来发展额外的技能:(1)旨在扩展她的方法技能的课程;(2)与赞助商和合作者组成的多学科团队进行互动;
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Evaluating elevated bilirubin levels in asymptomatic adults.
评估无症状成人胆红素水平升高。
- DOI:10.1001/jama.2014.12835
- 发表时间:2015
- 期刊:
- 影响因子:0
- 作者:VanWagner,LisaB;Green,RichardM
- 通讯作者:Green,RichardM
Associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: the Coronary Artery Risk Development in Young Adults Study.
- DOI:10.1016/j.atherosclerosis.2014.05.962
- 发表时间:2014-08
- 期刊:
- 影响因子:5.3
- 作者:VanWagner, Lisa B.;Ning, Hongyan;Lewis, Cora E.;Shay, Christina M.;Wilkins, John;Carr, J. Jeffrey;Terry, James G.;Lloyd-Jones, Donald M.;Jacobs, David R., Jr.;Carnethon, Mercedes R.
- 通讯作者:Carnethon, Mercedes R.
Elevated serum ferritin.
- DOI:10.1001/jama.2014.302
- 发表时间:2014-08-20
- 期刊:
- 影响因子:120.7
- 作者:VanWagner, Lisa B.;Green, Richard M.
- 通讯作者:Green, Richard M.
High early cardiovascular mortality after liver transplantation.
- DOI:10.1002/lt.23950
- 发表时间:2014-11
- 期刊:
- 影响因子:4.6
- 作者:VanWagner, Lisa B.;Lapin, Brittany;Levitsky, Josh;Wilkins, John T.;Abecassis, Michael M.;Skaro, Anton I.;Lloyd-Jones, Donald M.
- 通讯作者:Lloyd-Jones, Donald M.
Access to retransplantation after failed donation after circulatory death liver transplantation: eo ire itum.
循环死亡肝移植后捐献失败后获得再移植:eo ire itum。
- DOI:10.1111/ajt.12701
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Skaro,AI;Zhao,L;Vanwagner,LB;Abecassis,MM
- 通讯作者:Abecassis,MM
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Lisa B VanWagner其他文献
Lisa B VanWagner的其他文献
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{{ truncateString('Lisa B VanWagner', 18)}}的其他基金
1/4-The INTEGRATE Study: Evaluating INTEGRATEd Care to Improve Biopsychosocial Outcomes of Early Liver Transplantation for Alcohol-Associated Liver Disease
1/4-综合研究:评估综合护理以改善酒精相关性肝病早期肝移植的生物心理社会结果
- 批准号:
10712618 - 财政年份:2023
- 资助金额:
$ 5.94万 - 项目类别:
Blood pressure as a modifiable risk factor for cardiovascular events in liver transplant recipients
血压作为肝移植受者心血管事件的可改变危险因素
- 批准号:
10838640 - 财政年份:2021
- 资助金额:
$ 5.94万 - 项目类别:
Blood pressure as a modifiable risk factor for cardiovascular events in liver transplant recipients
血压作为肝移植受者心血管事件的可改变危险因素
- 批准号:
10094547 - 财政年份:2021
- 资助金额:
$ 5.94万 - 项目类别:
Implementation science to improve cardiovascular outcomes among liver transplant recipients
改善肝移植受者心血管结局的实施科学
- 批准号:
9295465 - 财政年份:2017
- 资助金额:
$ 5.94万 - 项目类别:
Derivation and validation of a cardiac risk index in liver transplantation
肝移植心脏风险指数的推导和验证
- 批准号:
8398068 - 财政年份:2012
- 资助金额:
$ 5.94万 - 项目类别:
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