Associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: the Coronary Artery Risk Development in Young Adults Study.
Associations between nonalcoholic fatty liver disease and subclinical atherosclerosis in middle-aged adults: the Coronary Artery Risk Development in Young Adults Study.
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DOI：
10.1016/j.atherosclerosis.2014.05.962
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发表时间：
2014-08
期刊：
影响因子：
5.3
通讯作者：
Carnethon, Mercedes R.
中科院分区：
文献类型：
--
作者：
VanWagner, Lisa B.;Ning, Hongyan;Lewis, Cora E.;Shay, Christina M.;Wilkins, John;Carr, J. Jeffrey;Terry, James G.;Lloyd-Jones, Donald M.;Jacobs, David R., Jr.;Carnethon, Mercedes R.
非酒精性脂肪性肝病（NAFLD）是一种与心血管死亡率相关的肥胖相关疾病。然而，NAFLD是否与动脉粥样硬化独立相关尚不清楚。在一个基于人群的无肝脏或心脏病的中年人横断面样本中，我们检验了NAFLD与亚临床动脉粥样硬化（冠状动脉（CAC）和腹主动脉钙化（AAC））相关的假设，而与肥胖无关。纳入了来自年轻成人冠状动脉风险发展研究的参与者，包括肝脏脂肪、CAC和AAC的CT定量（n= 2，424）。NAFLD定义为排除其他肝脂肪原因后肝脏衰减≤ 40 Hounsfield单位。CAC和AAC的存在被定义为Agatston评分> 0。平均受试者年龄为50.1±3.6岁（42.7%男性，50.0%黑人），BMI为30.6±7.2 kg/m2。NAFLD、CAC和AAC的患病率分别为9.6%、27.1%和51.4%。NAFLD参与者的CAC（37.9% vs. 26.0%，p<0.001）和AAC（65.1% vs. 49.9%，p<0.001）患病率增加。校正人口统计学和健康行为后，NAFLD仍与CAC（OR，1.33; 95%CI，1.001-1.82）和AAC（OR，1.74; 95%CI，1.29-2.35）相关。然而，在额外调整内脏脂肪组织后，这些相关性减弱（CAC OR，1.05; 95% CI，0.74-1.48，AAC OR=1.20; 95% CI，0.86-1.67）。种族或性别之间没有相互作用。与先前的研究相反，这些发现表明肥胖减弱了NAFLD和亚临床动脉粥样硬化之间的关系。需要进一步研究评估NAFLD持续时间对动脉粥样硬化进展和心血管事件的作用。
Non-alcoholic fatty liver disease (NAFLD) is an obesity-related condition associated with cardiovascular mortality. Yet, whether or not NAFLD is independently related to atherosclerosis is unclear. In a population-based cross-sectional sample of middle-aged adults free from liver or heart disease, we tested the hypothesis that NAFLD is associated with subclinical atherosclerosis (coronary artery (CAC) and abdominal aortic calcification (AAC)) independent of obesity. Participants from the Coronary Artery Risk Development in Young Adults study with CT quantification of liver fat, CAC and AAC were included (n=2,424). NAFLD was defined as liver attenuation ≤ 40 Hounsfield Units after exclusion of other causes of liver fat. CAC and AAC presence was defined as Agatston score > 0. Mean participant age was 50.1±3.6 years, (42.7% men, 50.0% black) and BMI was 30.6±7.2 kg/m2. The prevalence of NAFLD, CAC, and AAC was 9.6%, 27.1%, and 51.4%. NAFLD participants had increased prevalence of CAC (37.9% vs. 26.0%, p<0.001) and AAC (65.1% vs. 49.9%, p<0.001). NAFLD remained associated with CAC (OR, 1.33; 95% CI, 1.001–1.82) and AAC (OR, 1.74; 95% CI, 1.29–2.35) after adjustment for demographics and health behaviors. However, these associations were attenuated after additional adjustment for visceral adipose tissue (CAC OR, 1.05; 95% CI, 0.74–1.48, AAC OR=1.20; 95% CI, 0.86–1.67). There was no interaction by race or sex. In contrast to prior research, these findings suggest that obesity attenuates the relationship between NAFLD and subclinical atherosclerosis. Further studies evaluating the role of NAFLD duration on atherosclerotic progression and cardiovascular events are needed.
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非酒精性脂肪肝病与冠状动脉钙化有关。
影响因子：
13.5
作者：
Kim, Donghee;Choi, Su-Yeon;Park, Eun Ha;Lee, Whal;Kang, Jin Hwa;Kim, Won;Kim, Yoon Jun;Yoon, Jung-Hwan;Jeong, Sook Hyang;Lee, Dong Ho;Lee, Hyo-suk;Larson, Joseph;Therneau, Terry M.;Kim, W. Ray
通讯作者：
Kim, W. Ray
影响因子：
2.8
作者：
Lu H;Liu H;Hu F;Zou L;Luo S;Sun L
通讯作者：
Sun L
DOI：
10.1136/bmj.d6891
发表时间：
2011-11-18
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Lazo M;Hernaez R;Bonekamp S;Kamel IR;Brancati FL;Guallar E;Clark JM
通讯作者：
Clark JM
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH
影响因子：
5.3
作者：
Liu, Jiankang;Musani, Solomon K.;Fox, Caroline S.
通讯作者：
Fox, Caroline S.