IGF::OT::IGF LEUKOCYTE TELOMERE DYNAMICS, CARDIOVASCULAR AGING AND SURVIVAL IN T

该合同的主要目标是在两个时间点测量S健康倡议-长寿研究(WHI-LLS)参与者的长期寿命，以评估长期寿命动态(长期寿命及其与年龄相关的损耗)与冠心病(CHD)事件和死亡率的关系。承包商想要回答的中心问题如下：关于LTL的知识能否改善老年妇女的分类？S：冠心病和早期死亡的风险？回答这个问题与LLS的总体目标是一致的，该目标是支持与健康老龄化相关的因素的研究，并检查心血管疾病(CVD)风险的中间标记物在后续临床事件中的变化水平。为此，承包商将使用LTL测量来测试五个具体目标，这些目标将其动态与动脉粥样硬化性心血管疾病和寿命机械地联系起来。

The main goal of the contract is to measure LTL in Women¿s Health Initiative - Long Life Study (WHI-LLS) participants at two time points, approximately 15 years apart in order to assess LTL dynamics (LTL and its age-dependent attrition) in relation to incident coronary heart disease (CHD) events and mortality. The central question the contractor would like to answer is as follows: Can knowledge about LTL improve classification of an elderly woman¿s risk of CHD and early mortality? Answering this question is consistent with the overall goal of the LLS which is to support studies of factors associated with healthy aging and examine the changing levels of intermediate markers of cardiovascular disease (CVD) risk on subsequent clinical events. To this end, the contractor will use LTL measurements to test five specific aims that mechanistically link its dynamics to atherosclerotic CVD and longevity.