IGF::OT::IGF LEUKOCYTE TELOMERE DYNAMICS, CARDIOVASCULAR AGING AND SURVIVAL IN T

IGF::OT::IGF 白细胞端粒动力学、心血管衰老和 T 细胞存活

• 批准号: 8735521
• 负责人: N/A N/A
• 金额: $ 67.81万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-29 至 2014-03-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8735521
• 关键词: Aging; Atherosclerosis; Cardiovascular system; Classification; Clinical; Cohort Studies; Contractor; Contracts; Coronary heart disease; Data; Elderly woman; Event; Genes; Genotype; Goals; Knowledge; Leukocytes; Life; Link; Longevity; Measurement; Measures; Medical Records; Participant; Randomized; Relative (related person); Risk; Testing; Time; Woman; Women' s Health; age related; cardiovascular disorder risk; cardiovascular risk factor; cohort; follow-up; genetic variant; healthy aging; hormone therapy; improved; mortality; prospective; telomere

The main goal of the contract is to measure LTL in Women¿s Health Initiative - Long Life Study (WHI-LLS) participants at two time points, approximately 15 years apart in order to assess LTL dynamics (LTL and its age-dependent attrition) in relation to incident coronary heart disease (CHD) events and mortality. The central question the contractor would like to answer is as follows: Can knowledge about LTL improve classification of an elderly woman¿s risk of CHD and early mortality? Answering this question is consistent with the overall goal of the LLS which is to support studies of factors associated with healthy aging and examine the changing levels of intermediate markers of cardiovascular disease (CVD) risk on subsequent clinical events. To this end, the contractor will use LTL measurements to test five specific aims that mechanistically link its dynamics to atherosclerotic CVD and longevity.

该合同的主要目标是在两个时间点测量妇女健康倡议-长寿研究（WHI-LLS）参与者的LTL，大约间隔15年，以评估LTL动态（LTL及其年龄依赖性损耗）与冠心病（CHD）事件和死亡率的关系。承包商想要回答的核心问题是：关于LTL的知识是否可以改善老年妇女冠心病风险和早期死亡的分类？回答这个问题与LLS的总体目标是一致的，即支持与健康衰老相关因素的研究，并检查心血管疾病（CVD）风险中间标志物在随后临床事件中的变化水平。为此，承包商将使用LTL测量来测试五个特定目标，以机械地将其动态与动脉粥样硬化性心血管疾病和寿命联系起来。