INTEGRATIVE GENOMICS & RISK OF CORONARY HEART DISEASE & RELATED PHENOTYPES IN THE WOMEN'S HEALTH INITIATIVE3/29/2014 - 3/28/2015CAN: 14-8470187
综合基因组学
基本信息
- 批准号:8947315
- 负责人:
- 金额:$ 33.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-03-29 至 2015-03-28
- 项目状态:已结题
- 来源:
- 关键词:AgeBiologicalBiological MarkersBiologyBlood BanksClinicalContractorCoronary heart diseaseDNA FingerprintingDNA MethylationDataDiagnosticEventGenesGenetic MarkersGenomicsMediatingMethodologyMicroRNAsPathway interactionsPhenotypePlasmaPostmenopauseResolutionResourcesRiskRisk FactorsTechnologyTestingWomanWomen&aposs Healthage relatedfollow-upgenome wide association studygenome-widemembernovelprognostic
项目摘要
The contactor will take advantage of the existing large and unique Women’s Health Initiative (WHI) biological resource, which includes bio-banked blood from a large number of postmenopausal women who have been extensively phenotyped over a follow-up period of up to nineteen years. The contractor will carefully profile the DNA and plasma of Coronary Heart Disease (CHD) cases, as well as an appropriate set of controls, using two complementary, but well-validated, genomic technologies at baseline. These high throughput genomic technologies are expected to generate high quality and high-resolution genome wide DNA methylation profiles, as well as a comprehensive assessment of circulating microRNA levels in plasma. We will then comprehensively analyze and integrate this genomic data with existing clinical, genetic, and biomarker data using state of the art statistical methodologies developed by members of the investigative team to identify genomic signatures and pathways relevant to CHD and its risk factors.
该接触者将利用现有的大型和独特的妇女健康倡议(WHI)生物资源,其中包括生物库的血液从大量绝经后妇女谁已经广泛的表型随访期长达十九年。承包商将使用两种互补但经过充分验证的基因组技术,仔细分析冠心病病例的DNA和血浆,以及一套适当的对照。这些高通量基因组技术有望产生高质量和高分辨率的全基因组DNA甲基化谱,以及对血浆中循环microRNA水平的全面评估。然后,我们将全面分析这些基因组数据,并将其与现有的临床,遗传和生物标志物数据进行整合,使用由调查小组成员开发的最先进的统计方法,以确定与CHD及其风险因素相关的基因组特征和途径。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('N/A N/A', 18)}}的其他基金
NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICAL
肺病特异性人诱导多能干细胞国家生物库:该资源的目的是构建和支持关键的
- 批准号:
10469220 - 财政年份:2020
- 资助金额:
$ 33.1万 - 项目类别:
NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICAL
肺病特异性人诱导多能干细胞国家生物库:该资源的目的是构建和支持关键的
- 批准号:
10616457 - 财政年份:2020
- 资助金额:
$ 33.1万 - 项目类别:
NATIONAL BIOREPOSITORY OF LUNG DISEASE-SPECIFIC HUMAN INDUCED PLURIPOTENT STEM CELLS:THE PURPOSE OF THIS RESOURCE IS TO BUILD AND SUPPORT A CRITICAL
肺病特异性人诱导多能干细胞国家生物库:该资源的目的是构建和支持关键的
- 批准号:
10834813 - 财政年份:2020
- 资助金额:
$ 33.1万 - 项目类别:
INTEGRATIVE GENOMICS & RISK OF CORONARY HEART DISEASE & RELATED PHENOTYPES IN THE WOMEN'S HEALTH INITIATIVE3/29/2014 - 3/28/2015CAN: 14-8470187
综合基因组学
- 批准号:
9042180 - 财政年份:2013
- 资助金额:
$ 33.1万 - 项目类别:
IGF::OT::IGF METABOLOMICS OF CHD IN THE WHI
WHI 中 CHD 的 IGF::OT::IGF 代谢组学
- 批准号:
9042184 - 财政年份:2013
- 资助金额:
$ 33.1万 - 项目类别:
IGF::OT::IGF METABOLOMICS OF CHD IN THE WHI
WHI 中 CHD 的 IGF::OT::IGF 代谢组学
- 批准号:
8947302 - 财政年份:2013
- 资助金额:
$ 33.1万 - 项目类别:
IGF::OT::IGF LEUKOCYTE TELOMERE DYNAMICS, CARDIOVASCULAR AGING AND SURVIVAL IN T
IGF::OT::IGF 白细胞端粒动力学、心血管衰老和 T 细胞存活
- 批准号:
8735521 - 财政年份:2013
- 资助金额:
$ 33.1万 - 项目类别:
IGF::OT::IGF METABOLOMICS OF CHD IN THE WHI
WHI 中 CHD 的 IGF::OT::IGF 代谢组学
- 批准号:
8736167 - 财政年份:2013
- 资助金额:
$ 33.1万 - 项目类别:
IGF::OT::IGF R&D- MEDICAL: BIOMEDICAL (APPLIED RESEARCH/EXPLORATORY DEVELOPMENT)
IGF::OT::IGF R
- 批准号:
8735452 - 财政年份:2013
- 资助金额:
$ 33.1万 - 项目类别:
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