Phytoestrogen and Endogenous Estrogen Exposure and Risk of Stroke

植物雌激素和内源性雌激素暴露与中风风险

基本信息

  • 批准号:
    8403970
  • 负责人:
  • 金额:
    $ 63.76万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-03-15 至 2016-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Mounting evidence suggests that exposure to exogenous estrogens and estrogenic compounds such as selective estrogen receptor modulators (SERMs) and tibolone may increase the risk of stroke in women. Since phytoestrogens, plant-derived estrogens, are known to possess estrogenic effects similar to SERMs and have been marketed as natural and "safe" alternatives to estrogen therapy, significant concerns have been raised as to whether high exposure to phytoestrogens may confer the same risk of stroke. Another intriguing question has also arisen whether endogenous estrogen levels play a role in predicting stroke risk. We propose to address these questions in a prospective cohort of 74,942 adult Chinese women enrolled in the Shanghai Women's Health Study (SWHS) from 1997 to 2000. Specifically, we propose to verify incident stroke cases identified in this cohort during follow-up through medical record review. We will examine the association between dietary intake of soy phytoestrogens and risk of total stroke and stroke subtypes in the full cohort. Repeated dietary measurements will be used for the analyses. In addition, we propose to conduct a nested case-control study among postmenopausal women to investigate the association of ischemic stroke (the predominant type of stroke) with urinary levels of isoflavonoids, a biomarker of systemic exposure to phytoestrogens, and with blood levels of estradiol, estrone, testosterone, and sex hormone- binding globulin. We will include 1500 incident cases of ischemic stroke and 1500 individually matched controls. Isoflavonoids and sex hormones will be measured in biological samples collected at baseline using LC-MS based methods. The SWHS represents an exceptional opportunity to address the targeted questions given its large size, prospective design, high follow-up rates, extensive exposure and disease outcome information collected over the past decade, availability of biological samples, and the unique study population with a high level of soy consumption and low prevalence of hormone therapy use. Results of this proposed study will fill important gaps in our knowledge regarding the role of phytoestrogen and endogenous estrogen exposure in the etiology of stroke in women.
描述(由申请人提供):越来越多的证据表明,接触外源性雌激素和雌激素化合物,例如选择性雌激素受体调节剂(SERM)和替勃龙可能会增加女性中风的风险。由于植物雌激素(植物源性雌激素)已知具有与 SERM 类似的雌激素作用,并且已作为雌激素治疗的天然且“安全”的替代品上市,因此人们对大量接触植物雌激素是否会带来相同的中风风险提出了重大担忧。另一个有趣的问题还出现了,内源性雌激素水平是否在预测中风风险中发挥作用。我们建议通过 1997 年至 2000 年参加上海妇女健康研究 (SWHS) 的 74,942 名中国成年女性的前瞻性队列来解决这些问题。具体来说,我们建议通过医疗记录审查来核实在随访期间发现的中风病例。我们将研究整个队列中大豆植物雌激素的膳食摄入量与总中风和中风亚型风险之间的关联。重复的饮食测量将用于分析。此外,我们建议在绝经后妇女中进行一项巢式病例对照研究,以调查缺血性中风(中风的主要类型)与尿异黄酮水平(全身暴露于植物雌激素的生物标志物)以及血液中雌二醇、雌酮、睾酮和性激素结合球蛋白水平的关系。我们将纳入 1500 例缺血性中风病例和 1500 例单独匹配的对照。将使用基于 LC-MS 的方法测量基线收集的生物样品中的异黄酮和性激素。鉴于 SWHS 的规模大、前瞻性设计、高随访率、过去十年收集的广泛暴露和疾病结果信息、生物样本的可用性以及大豆消费水平高和激素治疗使用率低的独特研究人群,SWHS 提供了一个解决目标问题的绝佳机会。这项研究的结果将填补我们关于植物雌激素和内源性雌激素暴露在女性中风病因中的作用的重要空白。

项目成果

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Gong Yang其他文献

Gong Yang的其他文献

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{{ truncateString('Gong Yang', 18)}}的其他基金

Sex Hormones, Phytoestrogens and Lung Cancer in Female Nonsmokers
女性非吸烟者的性激素、植物雌激素和肺癌
  • 批准号:
    9007349
  • 财政年份:
    2015
  • 资助金额:
    $ 63.76万
  • 项目类别:
Inflammatory Biomarkers and Colorectal Cancer Risk
炎症生物标志物和结直肠癌风险
  • 批准号:
    7906697
  • 财政年份:
    2007
  • 资助金额:
    $ 63.76万
  • 项目类别:
Inflammatory Biomarkers and Colorectal Cancer Risk
炎症生物标志物和结直肠癌风险
  • 批准号:
    7498473
  • 财政年份:
    2007
  • 资助金额:
    $ 63.76万
  • 项目类别:
Inflammatory Biomarkers and Colorectal Cancer Risk
炎症生物标志物和结直肠癌风险
  • 批准号:
    7262313
  • 财政年份:
    2007
  • 资助金额:
    $ 63.76万
  • 项目类别:
Inflammatory Biomarkers and Colorectal Cancer Risk
炎症生物标志物和结直肠癌风险
  • 批准号:
    7683832
  • 财政年份:
    2007
  • 资助金额:
    $ 63.76万
  • 项目类别:

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