Vulnerability biomarkers for cocaine abuse and relapse
可卡因滥用和复发的脆弱性生物标志物
基本信息
- 批准号:8495966
- 负责人:
- 金额:$ 21.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2015-07-31
- 项目状态:已结题
- 来源:
- 关键词:AbstinenceAcuteAnimal ModelAreaAttenuatedBehaviorBiological MarkersBrainChronicCocaineCocaine AbuseCocaine DependenceConsumptionDataDevelopmentDiseaseDopamine D2 ReceptorDrug ExposureDrug usageEtiologyFunctional Magnetic Resonance ImagingHTR2A geneIndividualIndividual DifferencesLeadLiteratureMacaca mulattaMagnetic Resonance ImagingMaintenanceMediatingMetricModelingNeurobiologyPatientsPatternPharmaceutical PreparationsPhysiciansPositron-Emission TomographyPredisposing FactorPrefrontal CortexProceduresProcessProteinsPsychological reinforcementPublic HealthReceptor ActivationRecording of previous eventsRelapseResistanceSelf AdministrationSerotoninTechniquesTranslatingawakebasecocaine exposureeffective therapyfrontal lobehuman subjectinterestneuroimagingnonhuman primatenovelpublic health relevancereceptorresearch studyresponsesuccesstreatment planning
项目摘要
DESCRIPTION (provided by applicant): Abuse of cocaine is a widespread and severely deleterious public health problem. Although it is well established that there is substantial variability in an individual's response to cocaine exposure, we do not yet understand the mechanisms that mediate individual differences in the etiology of cocaine abuse and addiction. In particular, we do not understand why some individuals are resistant to the effects of cocaine and will consume cocaine at low rates whereas other individuals are relatively vulnerable to the effects of cocaine and will consume cocaine at high rates. In the present proposal, we will evaluate several novel biomarkers that may predict the vulnerability of an individual to abuse cocaine or to relapse following abstinence. We will evaluate these processes using drug self-administration (SA) and reinstatement of previously drug-maintained behavior in nonhuman primates, as these are well established animal models of cocaine abuse and relapse. Moreover, we propose to determine, in a highly systematic manner, whether the availability of specific brain proteins, the acute brain activational effects of cocaine, or the integrity of functional bran networks predicts cocaine abuse and relapse. We believe that these studies will have important public health implications because these techniques can be translated into use in human subjects, and they will allow physicians to individually tailor treatment plans based on the current status of the cocaine-dependent patient.
说明(由申请人提供):滥用可卡因是一个广泛和严重有害的公共卫生问题。虽然已经确定个体对可卡因暴露的反应存在很大的差异,但我们还不了解在可卡因滥用和成瘾的病因学中介导个体差异的机制。特别是,我们不明白为什么有些人对可卡因的影响有抵抗力,吸食可卡因的频率很低,而另一些人相对容易受到可卡因的影响,吸食可卡因的频率很高。在目前的建议中,我们将评估几种新的生物标志物,这些生物标志物可能预测个体滥用可卡因或戒断后复发的脆弱性。我们将在非人类灵长类动物中使用药物自我给药(SA)和恢复先前药物维持的行为来评估这些过程,因为这些是已经建立好的可卡因滥用和复发的动物模型。此外,我们建议以高度系统的方式确定特定脑蛋白的可用性、可卡因的急性脑激活效应或功能性脑网络的完整性是否预测可卡因滥用和复发。我们认为,这些研究将对公共卫生产生重要影响,因为这些技术可以转化为人类受试者的使用,它们将允许医生根据可卡因依赖患者的现状量身定制治疗计划。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
LEONARD L HOWELL其他文献
LEONARD L HOWELL的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('LEONARD L HOWELL', 18)}}的其他基金
Early life stress and adolescent cocaine abuse: neurobiological vulnerabilities
早期生活压力和青少年可卡因滥用:神经生物学脆弱性
- 批准号:
8936366 - 财政年份:2014
- 资助金额:
$ 21.42万 - 项目类别:
Early life stress and adolescent cocaine abuse: neurobiological vulnerabilities
早期生活压力和青少年可卡因滥用:神经生物学脆弱性
- 批准号:
8794163 - 财政年份:2014
- 资助金额:
$ 21.42万 - 项目类别:
Neuropharmacology of Abused Stimulants in Nonhuman Primates
非人类灵长类动物滥用兴奋剂的神经药理学
- 批准号:
8663206 - 财政年份:2012
- 资助金额:
$ 21.42万 - 项目类别:
Neuropharmacology of Abused Stimulants in Nonhuman Primates
非人类灵长类动物滥用兴奋剂的神经药理学
- 批准号:
8903700 - 财政年份:2012
- 资助金额:
$ 21.42万 - 项目类别:
Neuropharmacology of Abused Stimulants in Nonhuman Primates
非人类灵长类动物滥用兴奋剂的神经药理学
- 批准号:
9094694 - 财政年份:2012
- 资助金额:
$ 21.42万 - 项目类别:
Neuropharmacology of Abused Stimulants in Nonhuman Primates
非人类灵长类动物滥用兴奋剂的神经药理学
- 批准号:
8475570 - 财政年份:2012
- 资助金额:
$ 21.42万 - 项目类别:
Neuropharmacology of Abused Stimulants in Nonhuman Primates
非人类灵长类动物滥用兴奋剂的神经药理学
- 批准号:
8241468 - 财政年份:2012
- 资助金额:
$ 21.42万 - 项目类别:
FUNCTIONAL BRAIN ACTIVITY AFTER COCAINE USE & EXTINCTION THERAPY IN NHP
使用可卡因后的大脑功能活动
- 批准号:
8357568 - 财政年份:2011
- 资助金额:
$ 21.42万 - 项目类别:
相似海外基金
Research on the pathophysiology of acute transient psychosis using animal model
急性短暂性精神病动物模型病理生理学研究
- 批准号:
22K07589 - 财政年份:2022
- 资助金额:
$ 21.42万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A new monitoring method using transpulmonary thermodilution in an animal model of acute respiratory distress syndrome.
在急性呼吸窘迫综合征动物模型中使用经肺热稀释的新监测方法。
- 批准号:
21K16596 - 财政年份:2021
- 资助金额:
$ 21.42万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Testing existing and new therapeutic interventions in a novel animal model of acute Spot Positive intracranial hemorrhage
在急性斑点阳性颅内出血的新型动物模型中测试现有和新的治疗干预措施
- 批准号:
342058 - 财政年份:2016
- 资助金额:
$ 21.42万 - 项目类别:
Operating Grants
Development of a gene therapy approach to treat acute lung injury using a preclinical, large animal model
使用临床前大型动物模型开发治疗急性肺损伤的基因治疗方法
- 批准号:
9044084 - 财政年份:2016
- 资助金额:
$ 21.42万 - 项目类别:
Effect of Stem Cells derived from Human Exfoliated Decidious Teeth in animal model of acute liver failure-correlation between inflammation and regeneration in liver
人脱落乳牙干细胞在急性肝功能衰竭动物模型中的作用——肝脏炎症与再生的相关性
- 批准号:
15K08996 - 财政年份:2015
- 资助金额:
$ 21.42万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The search of the drug for the acute severe HBV hepatitis using animal model
动物模型寻找治疗急性重型乙型肝炎药物
- 批准号:
15K09003 - 财政年份:2015
- 资助金额:
$ 21.42万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A new animal model for stress-induced transition from acute to chronic pain
压力引起的急性疼痛向慢性疼痛转变的新动物模型
- 批准号:
8862455 - 财政年份:2014
- 资助金额:
$ 21.42万 - 项目类别:
A new animal model for stress-induced transition from acute to chronic pain
压力引起的急性疼痛向慢性疼痛转变的新动物模型
- 批准号:
9081225 - 财政年份:2014
- 资助金额:
$ 21.42万 - 项目类别:
Development of a animal model of acute encephalopathy and an antibody therapy
急性脑病动物模型的开发和抗体治疗
- 批准号:
26670500 - 财政年份:2014
- 资助金额:
$ 21.42万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
A new animal model for stress-induced transition from acute to chronic pain
压力引起的急性疼痛向慢性疼痛转变的新动物模型
- 批准号:
8976522 - 财政年份:2014
- 资助金额:
$ 21.42万 - 项目类别: