Quantifying Risk Factors for Nanoparticle Contact with UVB Exposed Skin

量化纳米颗粒接触 UVB 暴露皮肤的风险因素

• 批准号: 8272859
• 负责人: Lisa A DeLouise
• 金额: $ 34.17万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-05 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8272859
• 关键词: Acute; Allergic; Allergic Contact Dermatitis; Antigen-Presenting Cells; Antigens; Blood Circulation; Cells; Charge; Chronic; Contact hypersensitivity; Data; Defect; Dendritic Cells; Development; Dinitrofluorobenzene; Dose; Engineering; Environmental Health; Flow Cytometry; Generations; Goals; Health; Histology; Human; Immune; Immunosuppression; Impairment; In Vitro; Individual; Inflammation; Irritants; Knowledge; Measurement; Measures; Mediating; Methods; Metric; Modeling; Mus; Nerve; Neuraxis; Organ; Pattern; Penetration; Persons; Predisposition; Production; Property; Quantum Dots; Research; Risk; Risk Factors; Safety; Skin; T-Lymphocyte; Time; Ultraviolet B Radiation; Ultraviolet Rays; Water; Work; consumer product; cytokine; immune function; in vivo; keratinocyte; keratinocyte differentiation; knowledge base; lymph nodes; macrophage; mouse model; nanomaterials; nanoparticle; novel; response; trend

DESCRIPTION (provided by applicant): The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM skin exposure. We take a systematic approach to quantify effect on NM composition, charge, size on penetration through skin exposed to acute and chronic levels of ultraviolet radiation. Under conditions that NM penetrate skin we will characterize their association with epidermal cells, including antigen presenting cells to establish this as a mechanism of systemic transport. We will determine if and how NM may impact UVB induced immunosuppression and allergic contact hypersensitivity. Finally, we will determine if measuring inside-out water loss from skin is a viable means to assess outside-in NM penetration risk. This project will produce a concise body of work that will aid in assessing risk factors associated with unintentional NM skin exposure and discover novel mechanisms by which NM may impact skin immune function. PUBLIC HEALTH RELEVANCE: The expanding use of engineered nanomaterials (NM) in consumer products and technological applications has spurred environmental and consumer health and safety (H&S) concerns. This project investigates the question of NM contact on ultraviolet radiation exposed skin.

描述(由申请人提供)：工程纳米材料(NM)在消费产品和技术应用中的广泛使用引发了对环境和消费者健康与安全的担忧(H&S)。这个项目调查了NM皮肤暴露的问题。我们采用一种系统的方法来量化暴露在急性和慢性水平的紫外线辐射下的NM成分、电荷、大小对透过皮肤的渗透的影响。在NM穿透皮肤的条件下，我们将表征它们与表皮细胞(包括抗原提呈细胞)的联系，以确立这是一种全身运输机制。我们将确定NM是否以及如何影响UVB诱导的免疫抑制和变态反应性接触过敏。最后，我们将确定测量皮肤由内向外的水分损失是否是评估由外向内NM渗透风险的可行方法。该项目将产生一系列简明的工作，帮助评估与非故意NM皮肤暴露相关的风险因素，并发现NM可能影响皮肤免疫功能的新机制。 公共卫生相关性：工程纳米材料(NM)在消费产品和技术应用中的广泛使用引发了对环境和消费者健康与安全的担忧(H&S)。本课题研究紫外线照射下皮肤NM接触问题。